Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres

Jia, Wen; Liu, Jian Gang; Zhang, Yang De; Wang, Ji Wei; Wang, Jun; Sun, Cheng Yi; Pan, Yan; Yu, Chao; Li, Guo Zheng; Zhang, Heng; Gou, Ma Ling; Tu, Ming Jing; Qian, Zhi

doi:10.1080/10611860601149393

Cited by 23 publications

(15 citation statements)

References 7 publications

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“…Similar results for the targeting effects of magnetic drug delivery systems have been reported in the literature. 49,50 Downregulation of HDAC activity levels in melanoma tumors appears to be a novel approach to the treatment of cancer.…”

Section: Resultsmentioning

confidence: 99%

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Enriquez¹,

Rizvi²,

D’Souza³

et al. 2013

IJN

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Enhanced and targeted drug delivery using biodegradable microspheres is emerging as a promising approach for cancer therapy. The main objective of the present research was to formulate, characterize, and evaluate iron oxide (magnetic) containing a bovine serum albumin-based microsphere drug delivery system, capable of efficiently delivering sulforaphane, a histone deacetylase inhibitor, for an extended period of time in vivo. Magnetic microspheres were prepared by spray-drying and characterized for their physicochemical properties and dissolution profile. Further, they were evaluated for therapeutic efficacy in in vitro and in vivo systems. In vitro studies in B16 melanoma cells revealed that there was about 13%-16% more inhibition of cell viability when either 30 µM or 50 µM of sulforaphane was used with iron oxide in the polymeric carrier. Data from in vivo studies in C57BL/6 mice revealed that the magnetic microspheres (localized to the tumor site with the help of a strong magnet) inhibited 18% more tumor growth as compared with sulforaphane in solution. In addition, there was a 40% reduction in histone deacetylation levels in mice treated with iron oxide microspheres containing sulforaphane. Thus, magnetic microspheres are shown to be an effective drug delivery system for anticancer drugs.

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Section: Resultsmentioning

confidence: 99%

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Enriquez¹,

Rizvi²,

D’Souza³

et al. 2013

IJN

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“…Each sample was assayed in triplicate. In this study, drug loading (DL) and entrapment efficiency (EE) were calculated according to Equations 1 and 2 (Jia et al 2007); …”

Section: Drug Loading Determinationmentioning

confidence: 99%

Preparation of Biodegradable Polycaprolactone/Poly (ethylene glycol)/Polycaprolactone (PCEC) Nanoparticles

Jia

Gou

et al. 2008

Drug Delivery

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Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of ε-caprolactone initiated by poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared by solvent diffusion method or w/o/w double emulsion method. The obtained particles' morphology was observed on scanning electron microscopy, and the particle size distribution was determined using Malvern laser particle sizer. Bovine serum albumin was used as the model water-soluble protein drug, which was successfully encapsulated in PCEC nanoparticles, the drug release behavior was studied in detail. The hydrolytic degradation behavior of the PCEC nanoparticles was also studied.

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“…The polymer degradation rate can be tuned by adjusting particle size [5], molar ratio between lactic acid and glycolic acid [3], molecular weight, and porosity [6]. The particle surface may be functionalized to target specific tissues, or magnetically functional particles may be created to allow targeting specific locations in the body by an applied magnetic field [7][8][9][10][11][12][13][14][15][16]. There are three main techniques for microencapsulation: spray drying, coacervation (precipitation), and emulsification/solvent evaporation [17].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and sustained release from biodegradable microcapsules made by emulsification/freeze drying and spray/freeze drying

Yin

Yates

2009

Journal of Colloid and Interface Science

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Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres

Cited by 23 publications

References 7 publications

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Preparation of Biodegradable Polycaprolactone/Poly (ethylene glycol)/Polycaprolactone (PCEC) Nanoparticles

Encapsulation and sustained release from biodegradable microcapsules made by emulsification/freeze drying and spray/freeze drying

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