Preparation, characterization, and performance of magnetic iron–carbon composite microparticles for chemotherapy

Rudge, Scott R.; Kurtz, T.L; Vessely, Christina; Catterall, L.G; Williamson, D. L.

doi:10.1016/s0142-9612(00)00006-5

Cited by 229 publications

(124 citation statements)

References 10 publications

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“…A series of activated carbon/magnetic particle composites have been prepared. And several methods such as impregnation (Wang et al, 1994;Gorria et al, 2006), ball milling (Rudge et al, 2000), and chemical co-precipitation (Safařík et al, 1997;Oliveira et al, 2002) have been developed. Among these methods, chemical co-precipitation is the most promising one because it is simple and no special chemicals and procedures are needed.…”

Section: Magnetic-particle-modified Carbon Adsorbentmentioning

confidence: 99%

Research progress of novel adsorption processes in water purification: A review

2008

Journal of Environmental Sciences

395

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As an effective, efficient, and economic approach for water purification, adsorbents and adsorption processes have been widely studied and applied in different aspects for a long time. In the recent years, a lot of novel adsorption processes have been developed for enhancing the efficiency of removing the organic and inorganic contaminants from water. This article reviews some new adsorbents and advanced adsorption methods that specialize in their compositions, structures, functions, and characteristics used in water treatment. The review emphasizes adsorption/catalytic oxidation process, adsorption/catalytic reduction process, adsorption coupled with redox process, biomimetic sorbent and its sorption behaviors of POPs, and modified adsorbents and their water purification efficiency.

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Section: Magnetic-particle-modified Carbon Adsorbentmentioning

confidence: 99%

Research progress of novel adsorption processes in water purification: A review

2008

Journal of Environmental Sciences

395

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“…To overcome the disadvantages of powdered activated carbon and magnetic particles, several methods such as impregnation (Wang et al, 1994), ball milling (Rudge et al, 2000), and chemical coprecipitation (Š afařík et al, 1997;Oliveira et al, 2002) have been developed to combine them together to produce magnetic composites, which could be used as adsorbents to remove a wide range of organic pollutants over a broad pH rang and be separated by magnetic separation technology conveniently. Among these methods, chemical coprecipitation is the most promising because it is simple and no special chemicals and procedures are demanded.…”

Section: Introductionmentioning

confidence: 99%

CuFe2O4/activated carbon composite: A novel magnetic adsorbent for the removal of acid orange II and catalytic regeneration

et al. 2007

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CuFe 2 O 4 /activated carbon magnetic adsorbents, which combined the adsorption features of activated carbon with the magnetic and the excellent catalytic properties of powdered CuFe 2 O 4 , were developed using a simple chemical coprecipitation procedure. The prepared magnetic composites can be used to adsorb acid orange II (AO7) in water and subsequently, easily be separated from the medium by a magnetic technique. CuFe 2 O 4 /activated carbon magnetic adsorbents with mass ratio of 1:1, 1:1.5 and 1:2 were prepared. Magnetization measurements, BET surface area measurements, powder XRD and SEM were used to characterize the prepared adsorbents. The results indicate that the magnetic phase present is spinel copper ferrite and the presence of CuFe 2 O 4 did not significantly affect the surface area and pore structure of the activated carbon. The adsorption kinetics and adsorption isotherm of acid orange II (AO7) onto the composites at pH 5.2 also showed that the presence of CuFe 2 O 4 did not affect the adsorption capacity of the activated carbon. The thermal decomposition of AO7 adsorbed on the activated carbon and the composite was investigated by in situ FTIR, respectively. The results suggest that the composite has much higher catalytic activity than that of activated carbon, attributed to the presence of CuFe 2 O 4 . The variation of the adsorption capacity of the composites after several adsorption-regeneration cycles has also been studied.

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“…It might turn out particularly useful for biomedical in vivo applications in diagnostic applications such as MRI [1] and therapies such as sitespecific drug delivery [2,3] and magnetic particle hyperthermia [4,5]. MCNCs, in a form of microparticles (or microspheres), with embedded magnetic cores are especially proposed for in vitro applications [6,7] e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, it was also reported that carbon microparticles of size in the range 0.5÷5 µm may potentially be used for in vivo applications e.g. chemotherapy [2,8]. In this case other routes of administration to targeted place are required including intra-arterial administration [2] or catheterization [3,8,9].…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanocomposites for biomedical applications

Izydorzak-Woźniak

Leonowicz

2015

Mechanik

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Magnetic carbon nanocomposites (MCNCs), with different constitution and fractions of magnetic component, were fabricated by the pyrolysis of the polymeric precursor. X-ray diffraction, transmission electron microscopy and Raman spectroscopy revealed the presence of nanocrystallites (NCs) of Co, Fe 3 C and Ni embedded in porous, partially graphitized carbon matrix. Vibrating sample magnetometer measurements enabled to determine the correlation between NCs size distribution and magnetic properties. The magnetic studies confirmed that the coercivity, saturation and remanent magnetizations, as well as fraction of the magnetic component depend on the pyrolysis temperature. The Co#C and Fe 3 C#C composites exhibited ferromagnetic behaviour with a remanent to saturation magnetization (M R /M S ) ratio ranging from 0.25 to 0.3, whereas in the Ni containing samples a relatively small M R /M S ratio points to significant contribution of superparamagnetic interactions. The Ni#C composites, having superparamagnetic and/or ferromagnetic nanocrystallites in their volume, were chosen to check the ability of heat generation in a magnetic field. It was found that the hysteresis losses were the main mechanism of heat generation. The MCNCs obtained can potentially be applied for hyperthermia treatment. As the MCNCs are proposed for biomedical application the basic cytotoxicity test were performed to evaluate a potential toxic effect of the materials on MG-63 cells line. The test results confirmed that the composites containing Fe 3 C are non-cytotoxic whereas the majority of the Ni#C and Co#C composites was characterized as slightly or moderately cytotoxic. Keywords: magnetic carbon nanocomposite, magnetic properties, pyrolysis, cytotoxicity, biomedicine

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Preparation, characterization, and performance of magnetic iron–carbon composite microparticles for chemotherapy

Cited by 229 publications

References 10 publications

Research progress of novel adsorption processes in water purification: A review

Research progress of novel adsorption processes in water purification: A review

CuFe2O4/activated carbon composite: A novel magnetic adsorbent for the removal of acid orange II and catalytic regeneration

Magnetic nanocomposites for biomedical applications

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