Preparation, characterization and pulmonary pharmacokinetics of xyloglucan microspheres as dry powder inhalation

Mahajan, Hitendra S.; Gundare, Sadanand A

doi:10.1016/j.carbpol.2013.11.036

Cited by 44 publications

(20 citation statements)

References 19 publications

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“…Soluplus [26,27], Kolliphor [28], PVP [29,30] and HP-b-CD [31,32] were used as solubilizers in this study, and have been extensively used in pharmaceutical oral products. Montelukast sodium had an aqueous solubility of about 2 mg/ ml, indicating that it was slightly soluble in water [9,10]. Soluplus and Kolliphor significantly increased the drug solubility by 1.5-fold.…”

Section: Resultsmentioning

confidence: 98%

“…This drug is well tolerated in the treatment of chronic asthma and the relief symptoms of seasonal allergies in children and adults [3,5]. However, this drug has low aqueous solubility of 0.2 lg/ml [9] and high membrane permeability with a log P of 8.98, indicating that it is a class II molecule as per the Biopharmaceutics drug Classification System (BCS) [10,11]. Moreover, it is a light-sensitive compound, which must be protected from light [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Novel montelukast sodium-loaded clear oral solution prepared with hydroxypropyl-β-cyclodextrin as a solubilizer and stabilizer: enhanced stability and bioequivalence to commercial granules in rats

Kim

Kwon

et al. 2015

J Incl Phenom Macrocycl Chem

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To develop a montelukast sodium-loaded clear oral solution with enhanced stability that was bioequivalent to commercial granules in rats for the treatment of asthma, various montelukast sodium-loaded solutions were prepared with various amounts of solubilizers and stabilizer, and their solubility and stability were investigated. Furthermore, the dissolution and pharmacokinetic studies were carried out in rats with the optimised formulation and the commercial montelukast sodium-loaded granules. Among the solubilizers tested in this study, hydroxypropyl-b-cyclodextrin (HP-b-CD) was selected because it greatly improved the drug solubility and stability. Furthermore, EDTA sodium was used as a stabilizer because it gave excellent stability. In particular, the montelukast-loaded oral solution, an aqueous clear solution containing montelukast sodium, HP-b-CD, methylparaben sodium, propylparaben sodium and EDTA sodium at w/v percentages of 1.04/156/1.8/0.2/1, gave similar dissolution to the commercial granules in 0.5 % (w/v) sodium lauryl sulphate in water, FDA-regulated dissolution medium. This oral solution gave similar plasma concentrations and pharmacokinetic parameters to the commercial granules, suggesting that it was bioequivalent to the commercial granules in rats. Moreover, it was physically and chemically stable at 25°C/60 % RH and 40°C/75 % RH for at least 12 months. Thus, this oral solution is strongly recommended as an alternative to the oral montelukast-loaded product for the treatment of asthma.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Novel montelukast sodium-loaded clear oral solution prepared with hydroxypropyl-β-cyclodextrin as a solubilizer and stabilizer: enhanced stability and bioequivalence to commercial granules in rats

Kim

Kwon

et al. 2015

J Incl Phenom Macrocycl Chem

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“…The response surface methodology used numerical and graphical optimization method to complete the optimization study and proposed a model (Equation 1, 2) to calculate the responses (yield) of TWSP and PWSP (Mahajan & Gundare, ).…”

Section: Resultsmentioning

confidence: 99%

“…The media was then inocu-lated separately with L. delbrueckii and L. fermentum under aseptic condition and incubated anaerobically at 37 C. Sampling for optical density (OD) was done at 0-96 hr with 12 hr interval. The growth rate of probiotics over fermentation time was calculated according to the formula: Growth rate = OD of latest fermentation time− OD of previous fermentation time OD of previous fermentation time 3 | RESULTS AND DISCUSSION 3.1 | Extraction and purification of polysaccharides The response surface methodology used numerical and graphical optimization method to complete the optimization study and proposed a model (Equation 1, 2) to calculate the responses (yield) of TWSP and PWSP(Mahajan & Gundare, 2014).In TWSP(Figure 1a), the obtained yield was increased up to a maximum of 48.4% (w/w) at the extraction temperature of 65-70 C, while further increase in temperature does not affect the extraction efficiency of the polysaccharide. The yield (Y) is obtained based on the equation as follows: Y = 0:46 + 0:081A− 7:958e −3 B + 0:034C − 5e −3 AB + 0:017AC + 0:016BC − 0:093A 2 − 0:015B 2 − 0:015C 2…”

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confidence: 99%

Extraction and characterization of water‐soluble polysaccharides from Tamarindus indica and Pithecellobium dulce seeds

Sivakumar

Kavitha

2019

J Food Process Engineering

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Water‐soluble polysaccharides (WSP) were secluded from Tamarindus indica (TWSP) and Pithecellobium dulce (PWSP) seeds by hot water method. The physico‐chemical properties revealed that the polysaccharides might be used as a potential food additive. The micrometric properties of TWSP and PWSP possessed a bulk density of 0.64 and 0.68 g/ml, respectively. The isolated polysaccharides were subjected to Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopy for its compositional analysis and exhibited that both the isolates are heteropolysaccharides. The spectra of both the mucilages were resonating at δ 3.00–δ 5.00 ppm which confirmed the presence of polysaccharides. Thermo gravimetric analysis showed that the isolated polysaccharides were thermally stable. Scanning electron microscopy and X‐ray diffraction depicted the morphological characteristics. The radical scavenging ability and antibacterial activity proved that the polysaccharides can be explored as a functional food ingredient. Furthermore, the prebiotic potential of polysaccharides stimulated the growth of Lactobacillus delbrueckii and Lactobacillus fermentum over inulin. Practical applications The study provides optimum extraction conditions to obtain TWSP and PWSP seeds using response surface methodology. The isolated polysaccharides can be used as therapeutic agent and as a food additive due to its high purity obtained from Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopic analysis. The excellent flowability and compressibility of polysaccharides can be applied in pharmaceutical formulation as an excipient. The active component present in the isolated polysaccharides can be used as a food preservative. The supplement of TWSP and PWSP as a carbon source accelerated the growth of probiotics which could be used as natural prebiotics. Thus the study concluded that the water‐soluble polysaccharide obtained from the agro‐industrial by product has the wide application in food and pharmaceutical industries.

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“…Xyloglucan has been used in both food and nonfood products in various applications including emulsification (Yuji & Soichiro, 2000), stabilization (Hiroomi & Takuya, 2002;Mayumi & Hiroyuki, 2000;Susumu, 2003), gelling (Ichiro, 2004;Kazuo, 2000;Takao & Katsumi, 2004;Yasuhiro, 2004), textural improvement (Norifumi, 2000(Norifumi, , 2003, thickening (Hidemi & Katsuhiro, 2004;Taiji, 2003), crystallization inhibition (Kanae & Tadanobu, 2002;Mayuko, 2005), and bulking (Mayuko, 2005;Tadanobu, 2004). Apart from the uses of xyloglucan in traditional industry, native and modified xyloglucans have been studied for use as biomaterial in tissue engineering (Bodin et al, 2007), as an antiviral agent (Mastromarino et al, 1997), and as a drug delivery vehicle (Mahajan & Gundare, 2014;Miyazaki et al, 1998Miyazaki et al, , 2001. Mahajan and Deshmukh (2015) suggested that xyloglucan can perform as a potential film-forming polymer for ocular delivery of a ciprofloxacin, an antibacterial agent useful in eye infection treatment.…”

Section: Introductionmentioning

confidence: 99%

Production of xyloglucan component extracted from tamarind ( Tamarindus indica ) seeds using microwave treatment for seed decortication

Nguyễn

Jittanit

Srichamnong

2019

J Food Process Preserv

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Microwave treatment was applied for tamarind seed decortication and the decorticated seeds were milled and used for xyloglucan extraction. The aims were: (1) to determine a treatment for efficiently decorticating tamarind seeds with the specified moisture content and color of decorticated seeds and (2) to develop extraction and purification techniques for producing high‐purity xyloglucan component powder from tamarind seeds. The results revealed that the application of microwave treatment produced high decortication yield and satisfactory color of decorticated seeds. Defatting tamarind kernel powder (TKP) using TKP:hexane ratio of 1:10 (wt/vol) was preferable for reducing fat to 0.5%. The xyloglucan component powder extracted from defatted TKP using 95% ethanol in precipitation process with protease enzyme application for 3 hr had comparable glucose, xylose, and galactose contents to the commercial xyloglucan standard. Overall production yields were 45.6%, 40.2%, and 25.8% for TKP, defatted TKP, and xyloglucan component powder with high purity, respectively. Practical applications The xyloglucan in tamarind seeds is a natural, nontoxic, and edible polysaccharide. Xyloglucan normally forms a gel in the presence of alcohol, sugar, and polyphenols. It is an interesting gelling agent for use in the food industry because it can form a gel over a wide pH range and is rather heat stable. Although a number of companies in some countries such as Japan and China have manufactured and exported xyloglucan powder extracted from tamarind seeds for many years, their processing techniques have not been disseminated. In this study, a microwave treatment was applied for tamarind seed decortication. The decorticated seeds were milled and used for xyloglucan extraction. The processes for xyloglucan extraction and purification were investigated. The xyloglucan component powder produced in this study had comparable glucose, xylose, and galactose contents to the commercial xyloglucan standard. The xyloglucan component powder produced in this study could be sold as a food additive.

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Preparation, characterization and pulmonary pharmacokinetics of xyloglucan microspheres as dry powder inhalation

Cited by 44 publications

References 19 publications

Novel montelukast sodium-loaded clear oral solution prepared with hydroxypropyl-β-cyclodextrin as a solubilizer and stabilizer: enhanced stability and bioequivalence to commercial granules in rats

Novel montelukast sodium-loaded clear oral solution prepared with hydroxypropyl-β-cyclodextrin as a solubilizer and stabilizer: enhanced stability and bioequivalence to commercial granules in rats

Extraction and characterization of water‐soluble polysaccharides from Tamarindus indica and Pithecellobium dulce seeds

Production of xyloglucan component extracted from tamarind ( Tamarindus indica ) seeds using microwave treatment for seed decortication

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