Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

Abstract

The reaction of 6-amino pencillanic acid with Schiff base "(Z)-3-((3-hydroxybenzylidene) amino) phenol)" has formed a novel Azo-azomethine ligand (HL) "( 7-((Z)-(2-hydroxy-4-((Z)-((3-hydroxyphenyl) imino) methyl) phenyl) diazenyl)-3, 3dimethyl-6-oxo-2-thiabicyclo [3.2.0] heptane-4-carboxylic acid". The ligand (HL) is characterized by 1 H-NMR, 13 C-NMR, Mass Spectrometry, CHNs, Uv-Visible, and FT-IR. This new Ligand (HL) is used to prepare numerous complexes using transition metal ions Fe (II) Cu (II), and Ni (II). These complexes' properties are studied using different techniques such as Mass Spectroscopy, Atomic Absorption, FT-IR, UV-Visible, Magnetic Moment, and Molars Conductivity. All these techniques indicate 1:2 (M: L) stoichiometry's synthesized complexes. Azo-azomethine ligand (HL) acts as a tridentate ligand to form the octahedral shape complexes with sp 3 d 2 , d 2 sp 3 hybridization. These new ligands and complexes are studied for their biological activity. The results show that the minimum inhibition concentration (MIC) of the prepared compounds has inhibition activity against Staphylococcus aureus bacteria and obviously affects the ability of pathogenic bacteria (S. aureus) to attain virulence factors such as Biofilm and hemolysin toxin

Synthesis, Characterization and Spectral Studies of Some Metal Ions Complexes with New Schiff Base Ligand Derived From 6- Amino Penicillanic Acid And Biological Screening Study For The Pt(II) Complex.

“…The most important infrared spectral bands that provided conclusive structural evidence for the coordination of the ligand to the central metal ions are given in Table 2. The FI-IR spectrum of the ligand shows characteristic bands at (1698 and 1653) cm -1 due to the (C=N) functional group [9]. The (C=N) and band in the free ligand shift to (1666-1597) cm -1 for the complex, these shifts confirm the coordination of the ligand via the nitrogen of azomethine group to metal ions [10,11].…”

Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes

“…The IR spectra of the metal complexes and free ligand are compared to determine the changes created during the complexation process [36][37]. The IR spectra of the metal complexes and free ligand were presented in Fig.…”