Preparation, characterization, antioxidant and antianemia activities of Poria cocos polysaccharide iron (III) complex

Zhang, Yue; Huang, Jiajing; Sun, Ming-jie; Duan, Yuting; Wang, Lei; Yu, Nianjun; Peng, Daiyin; Chen, Weidong; Wang, Yanyan

doi:10.1016/j.heliyon.2023.e12819

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…Table 1 summarizes the preparation of PIC from different sources by using the iron chloride co-heating method. [13,[22][23][24][25][26][27][28][29][30][31][32][33] The reaction principle is roughly as follows: sodium citrate is used as a catalyst to catalyze the reaction between iron chloride and polysaccharides. NaOH is used to adjust the pH to generate a reddish brown precipitate.…”

Section: Iron Chloride Co-thermal Synthesis Methodsmentioning

confidence: 99%

“…The principles and characteristics of these methods have been analyzed below, and the relevant research results are shown in Table 2. [17,[23][24][25][26]28,[32][33]24,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]…”

Section: Determination Of Iron Content In Compositesmentioning

confidence: 99%

“…Hence, it can extend the dosing interval or reduce the number of dosing times. [55] Zhang et al [23] investigated the digestive characteristics of Poria cocos polysaccharide iron (III) complex (PC-PIC) in a simulated gastrointestinal environment. Almost 85% of Fe 3+ was released within 120 min of simulating the gastric juice environment.…”

Section: Digestive Characteristicsmentioning

confidence: 99%

“…The principles and characteristics of these methods have been analyzed below, and the relevant research results are shown in Table 2 . [ 17,23–26,28,32–33,24,36–52 ]…”

Section: Determination Of Iron Content In Compositesmentioning

confidence: 99%

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Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Dai,

Hao,

Gao

et al. 2023

Starch Stärke

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Iron is an essential trace element in the human body. Iron deficiency can lead to iron deficiency anemia (IDA) and induce various diseases. Hence, it is urgent to find an iron supplement with minimal side effects and good iron supplementation effect. Natural polysaccharides from plants have various biological activities such as antioxidant, hypoglycemic, immunomodulatory, etc. Increasing research has shown that polysaccharides modified with iron can enhance their biological activities. Among them, polysaccharide iron complex (PIC) has significant anti‐anemia activity. With the powerfully development of PIC, increasing research has found that PIC showed some advantages, including good water solubility, high bioavailability, low gastrointestinal irritation, and high iron content. Therefore, PIC has received widespread attention. Currently, PIC is widely used in various fields such as agriculture, animal husbandry, and clinical treatment. However, there are limited reports on the preparation, biological activities, and applications of PIC. This paper systematically reviews the preparation methods, iron content determination methods, biological activities, and applications of PIC. The results provide important references for the deep development and utilization of PIC.

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Section: Iron Chloride Co-thermal Synthesis Methodsmentioning

confidence: 99%

Section: Determination Of Iron Content In Compositesmentioning

confidence: 99%

Section: Digestive Characteristicsmentioning

confidence: 99%

“…The principles and characteristics of these methods have been analyzed below, and the relevant research results are shown in Table 2 . [ 17,23–26,28,32–33,24,36–52 ]…”

Section: Determination Of Iron Content In Compositesmentioning

confidence: 99%

See 2 more Smart Citations

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Dai,

Hao,

Gao

et al. 2023

Starch Stärke

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show abstract

“…Zhang et al prepared a Poria cocos polysaccharide-iron (III) complex. They found that it showed a better ability to scavenge free radicals and better antioxidant activity than Poria cocos polysaccharides and they suggested the form of β-FeOOH might affect the stability of the complex [ 13 ]. Furthermore, another polysaccharide-iron (III) complex prepared with a polysaccharide from pacific abalone showed that iron (III) was combined with polysaccharide by the Fe-O bond.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization, In Vitro Digestion Property, and Biological Activity of Sweet Corn Cob Polysaccharide Iron (III) Complexes

Xiu

Wang

et al. 2023

Molecules

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This study aimed to enhance the utilization value of sweet corn cob, an agricultural cereal byproduct. Sweet corn cob polysaccharide-ron (III) complexes were prepared at four different temperatures (40 °C, 50 °C, 60 °C, and 70 °C). It was demonstrated that the complexes prepared at different temperatures were successfully bound to iron (III), and there was no significant difference in chemical composition; and SCCP-Fe-C demonstrated the highest iron content. The structural characterization suggested that sweet corn cob polysaccharide (SCCP) formed stable β-FeOOH iron nuclei with −OH and −OOH. All the four complexes’ thermal stability was enhanced, especially in SCCP-Fe-C. In vitro iron (III) release experiments revealed that all four complexes were rapidly released and acted as iron (III) supplements. Moreover, in vitro antioxidant, α-glucosidase, and α-amylase inhibition studies revealed that the biological activities of all four complexes were enhanced compared with those of SCCP. SCCP-Fe-B and SCCP-Fe-C exhibited the highest in vitro antioxidant, α-glucosidase, and α-amylase inhibition abilities. This study will suggest using sweet corn cobs, a natural agricultural cereal byproduct, in functional foods. Furthermore, we proposed that the complexes prepared from agricultural byproducts can be used as a potential iron supplement.

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Preclinical study of pachyman inducing ferroptosis against ovarian cancer: Biological targets and underlying mechanisms

Deng

Xin

et al. 2023

Food Science & Nutrition

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Ferroptosis has gained extreme purpose in targeting cancer treatment. Poria cocos Wolf, a traditional Chinese herb, has potential anticancer properties, but the action and mechanism against ovarian cancer remain undetailed. Pachyman (Poria cocos polysaccharides) refers to the pharmacologically bioactive ingredients rich in Poria cocos. This study aimed to identify the potent actions and the network mechanisms of pachyman against ovarian cancer through preclinical analysis. Online‐accessible database or platform was employed to predict candidate genes and core targets associated with ferroptosis in pachyman against ovarian cancer. Enrichment analyses were used to characterize the functional action and signaling mechanism in pachyman to treat ovarian cancer. Molecular docking imitation was conducted for verification of core target proteins. Network analysis uncovered that there were 30 mutual and 13 core genes targeting ferroptosis in pachyman and/against ovarian cancer, and additional enrichment analysis characterized that these core genes may act synergistically through multiple biological processes and molecular pathways associated with ferroptosis, including anti‐inflammatory action, immunoregulation, and microenvironment modulation. The strongest affinities in core target proteins between pachyman and sarcoma (SRC), signal transducer, and activator of transcription 3 (STAT3) were further validated using molecular docking method. In conclusion, pachyman may induce antiovarian cancer potentials via regulating ferroptosis‐associated biological functions and pharmacological mechanisms based on current bioinformatics findings. We reason that pachyman, the beneficial nutraceuticals, may be used clinically for future application in ovarian cancer treatment.

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Preparation, characterization, antioxidant and antianemia activities of Poria cocos polysaccharide iron (III) complex

Cited by 16 publications

References 38 publications

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Structural Characterization, In Vitro Digestion Property, and Biological Activity of Sweet Corn Cob Polysaccharide Iron (III) Complexes

Preclinical study of pachyman inducing ferroptosis against ovarian cancer: Biological targets and underlying mechanisms

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