Preparation, Characterization, in-vitro and in-vivo Pharmacokinetic Evaluation of Thermostable Dimethyl Fumarate Cocrystals

Alam, Qadir; Ganeshpurkar, Ankit; Singh, Sushil Kumar; Krishnamurthy, Sairam

doi:10.1016/j.xphs.2023.07.001

Cited by 2 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These benefits suit sustained, long-term delivery and can improve patient experiences. 5 Donepezil hydrochloride belongs to class I of the Biopharmaceutical classification system (BCS) with high solubility and high permeability. It is used in the management of Alzheimer's disease and suits transdermal delivery due to its long half-life, lesser dose, and minimal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

SK,

2022

IJDDT

View full text Add to dashboard Cite

This study aimed to develop a donepezil hydrochloride (DH) transdermal drug delivery system to address non-compliance due to dementia in Alzheimer’s patients. DH has a low dose, balanced hydrophilicity/lipophilicity, and low toxicity making it suitable for transdermal. DH transdermal patches were prepared using a polymer and plasticizer matrix system via box-Behnken design and evaluated for properties. Formulation B2 containing hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), and xanthan gum was optimal, exhibiting a maximum of ~99.17% in-vitro drug release for 48 hours. In-vivo pharmacokinetic parameters studied in rabbits were superior to commercial DH tablets. The study demonstrates the potential for DH transdermal patches as an alternative to oral medication for Alzheimer’s patients. The patches can provide sustained release for prolonged periods without requiring multiple doses. However, further confirmation is needed via in-vivo pharmacodynamic and human pharmacokinetic studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

SK,

2022

IJDDT

View full text Add to dashboard Cite

show abstract

In Silico Evaluation of Bioactive Compounds from Gokshura (Tribulus terrestris L.) and Punarnava (Boerhavia diffusa L.) for their Nephroprotective Activity in Chronic Kidney Disease and Related Complications

Urkude,

Acharya,

Pawar

et al. 2024

View full text Add to dashboard Cite

Kidney diseases are one of the leading causes of mortality worldwide. Diabetes and hypertension are the main causes of kidney failure resulting in 3 out of 4 new cases. Most of the conventional drugs used in various disease conditions are reported for their nephrotoxic actions and their continuous use can also damage the kidneys. Ayurveda recommends certain herbal drugs like Gokshura (Tribulus terrestris L.) and Punarnava (Boerhavia diffusa L.) which can control endstage kidney disease and its complications through the rejuvenation of the kidneys. The present study is an effort to show the nephroprotective potential of bioactive compounds present in Tribulus terrestris L. and Boerhavia diffusa L. against critical nephroprotective targets carbonic anhydrase II, renin, HIF propyl hydroxylase 2/ EGLN1, angiotensin-converting enzyme II, vasopressin receptor 2 against their respective standard drugs through in silico technique and to verify the probable efficacy of these herbs in chronic kidney disease against modern medication. Discovery Studio (DS Visualizer 2016) and Auto Dock tool (ADT Tools-1.5.6) were used for molecular docking. Among the major bioactive compounds screened, chlorogenin, hecogenin, diosgenin, neotigogenin and beta-sitosterol from Tribulus terrestris L., Beta-sitosterol, boerhavisterol, liriodenine, boerhadiffusene and ursolic acid from Boerhavia diffusa L. observed to exhibit significantly higher binding energy (BE) and inhibition constant (IC50) towards CA II, Renin, EGLN1, ACE II and V2R than their respective standard drugs. The study has demonstrated the nephroprotective activity of Tribulus terrestris L. and Boerhavia diffusa L. by inhibiting receptor activity against standard drug molecules.

show abstract

Preparation, Characterization, in-vitro and in-vivo Pharmacokinetic Evaluation of Thermostable Dimethyl Fumarate Cocrystals

Cited by 2 publications

References 39 publications

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

<i>In Silico</i> Evaluation of Bioactive Compounds from Gokshura (<i>Tribulus terrestris</i> L.) and <i>Punarnava</i> (<i>Boerhavia diffusa</i> L.) for their Nephroprotective Activity in Chronic Kidney Disease and Related Complications

Contact Info

Product

Resources

About