Preparation, characterization, structural analysis and antioxidant activities of phosphorylated polysaccharide from Sanchi (Panax notoginseng) flower

Huo, Nailin; Ameer, Kashif; Wu, Zhaogen; Yan, Shengnan; Jiang, Guihun; Ramachandraiah, Karna

doi:10.1007/s13197-022-05539-5

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…In situ FTIR analysis is shown in Figure . A large band caused by hydroxyl tensile vibration or polymer appears near 3400 cm –1 . The vibration peak due to the absorption tends to weaken as the reaction proceeds, indicating that the polymer is hydrolyzed.…”

Section: Results and Discussionmentioning

confidence: 99%

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Study of the Mechanism of Hydrolysis of Hemicellulose from Lignocellulose during Alkali Thermal Pretreatment by Density Functional Theory and Experiment

Tian,

Mao,

et al. 2024

J. Org. Chem.

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The covalent bond fracture of hemicellulose leads to hemicellulose hydrolysis during lignocellulosic alkali thermal pretreatment, which has not previously been reported. Density functional theory was used to study the mechanism of hydrolysis of the hemicellulose model compounds under alkali conditions. There are four reaction paths for xylose formation, among which the reaction path with the lowest energy barrier is that in which the nucleophile captures H30 to generate water. The deprotonated hydroxyl group attacks the carbon on the glycoside bond, resulting in the cleavage of the glycoside bond and the formation of a new carbon−oxygen covalent bond, with an energy barrier of 154.2 kJ/mol. The nucleophile further attacks the glycosidic bond to form a new xylose residue with an energy barrier of 111.9 kJ/mol. When the glycosidic bond breaks, the orbital interaction with the largest proportion causes the transfer of ∼0.511 electron from the glycosidic bond oxygen to the deprotonated hydroxy oxygen. In situ Fourier transform infrared spectroscopy is used for the identification of functional groups during the alkali thermal pretreatment. As the temperature increases, the feasibility of the reaction increases. This study lays a theoretical foundation for the development of the alkali thermal pretreatment of lignocellulose.

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Section: Results and Discussionmentioning

confidence: 99%

“…A large band caused by hydroxyl tensile vibration or polymer appears near 3400 cm −1 . 39 The vibration peak due to the absorption tends to weaken as the reaction proceeds, indicating that the polymer is hydrolyzed. There is an absorption peak near 2900 cm −1 , which may be the tensile vibrations of -CH 3 , -CH 2 , and -CH.…”

Section: Resultsmentioning

confidence: 99%

Study of the Mechanism of Hydrolysis of Hemicellulose from Lignocellulose during Alkali Thermal Pretreatment by Density Functional Theory and Experiment

Tian,

Mao,

et al. 2024

J. Org. Chem.

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“…Some of them are listed by the International Union for the Conservation of Nature (IUCN) under various threat categories which necessitate conservation efforts. Opuntioideae is the richest genus within the Cactaceae of nearly 200 described species (Huo et al, 2022 ; Majure et al, 2012 ; Majure & Puente, 2014 ). Opuntia species are highly distributed throughout arid and semi‐arid environments and are well‐adapted to drought‐stressed conditions (Aliscioni et al, 2021 ; Majure et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling, antimicrobial, and antioxidant activities of hydroethanolic extracts of prickly pear (Opuntia ficus indica) fruit and pulp

Iftikhar

Siddique

Ameer

et al. 2023

Food Science & Nutrition

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Phenolic compounds in prickly pear [Opuntia ficus indica (L.) Mill.] are known to contribute to the antioxidant and antimicrobial activities of the prickly pear. The present study aimed to evaluate the antioxidants and in vitro antimicrobial potential in the hydroethanolic extracts of different parts (fruit, cladode, and pulp) of prickly pear. Different polyphenolic compounds were analyzed by using high‐performance liquid chromatography. The results indicated that cladode possessed a higher quantity of phenolics compared with that observed in fruit and pulp. The most important phenolic compound in high quantity was gallic acid (66.19 μg/g) in cladode. The 100% aqueous extract of cladode exhibited the highest antioxidant (92%) and antimicrobial activities against Salmonella typhi (3.40 mg/ml), Helicobacter pylori (1.37 mg/ml), Escherichia coli (1.41 mg/ml), and Staphylococcus aureus (1.41 mg/ml). Principal component analysis (PCA) indicated that antioxidant activity and minimum inhibitory concentration (MIC) responses had a significant negative correlation with each other. Overall, the current results provided basic data for choosing prickly pear cladode with high antioxidant capacity for the development and consumption of antioxidant‐based alternative medicines and value addition of formulated foods.

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“…Panax notoginseng (Burk.) F. H. Chen (also known as Sanqi) has been used for thousands of years in China to promote blood circulation, remove blood stasis, induce hemostasis, and relieve swelling and pain (Huo et al, 2022). Notoginsenoside R1 belongs to the protopanax triol type and is the main monomeric component isolated from Panax ginseng that exerts anti-inflammatory, antioxidant, and anti-apoptotic effects (Pang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Exploring the molecular mechanism of notoginsenoside R1 in sepsis-induced cardiomyopathy based on network pharmacology and experiments validation

Shao

Li²,

Chen³

et al. 2023

Front. Pharmacol.

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Sepsis-induced cardiomyopathy (SIC) is an important manifestation of sepsis, and abnormal cardiac function affects the development of sepsis. Notoginsenoside R1 (NG-R1) is a unique bioactive component of Panax notoginseng with anti-inflammatory and antioxidant effects. However, the effects and possible mechanisms of NG-R1 on SIC are not clear. The purpose of this study was to identify the potential targets and regulatory mechanisms of the action of NG-R1 on SIC. To investigate the potential mechanism, we used network pharmacology, molecular docking, qRT-PCR, and immunofluorescence. The results showed that NG-R1 ameliorated myocardial fibrosis in septic mice. Validation of network pharmacology and molecular docking results revealed that NG-R1 reduced tumor necrosis factor-Alpha (TNF-α) expression in myocardial tissues and AC16 cardiomyocytes in mice, as well as inflammatory factor release in AC16 cells, so TNF-α may be a potential target of NG-R1 against SIC. The present study demonstrated that NG-R1 could protect against SIC and by regulating the expression of TNF-α inflammatory factors, providing a new idea for sepsis drug development.

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Preparation, characterization, structural analysis and antioxidant activities of phosphorylated polysaccharide from Sanchi (Panax notoginseng) flower

Cited by 13 publications

References 18 publications

Study of the Mechanism of Hydrolysis of Hemicellulose from Lignocellulose during Alkali Thermal Pretreatment by Density Functional Theory and Experiment

Study of the Mechanism of Hydrolysis of Hemicellulose from Lignocellulose during Alkali Thermal Pretreatment by Density Functional Theory and Experiment

Phytochemical profiling, antimicrobial, and antioxidant activities of hydroethanolic extracts of prickly pear (Opuntia ficus indica) fruit and pulp

Exploring the molecular mechanism of notoginsenoside R1 in sepsis-induced cardiomyopathy based on network pharmacology and experiments validation

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