Preparation, formation mechanism and in vitro dynamic digestion behavior of quercetin-loaded liposomes in hydrogels

Li, Weilin; Kong, Youyu; Ye, Aiqian; Shen, Ping; Dong, Lu; Xu, Xiankang; Hou, Yingying; Wang, Yanping; Jin, Yangyi; Han, Jianzhong

doi:10.1016/j.foodhyd.2020.105743

Cited by 47 publications

(26 citation statements)

References 49 publications

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“…The thin-film dispersion method was used to prepare BVP-LP [24,25,27,28]. 1.0 g phospholipid and 0.25 g cholesterol were accurately weighed and dissolved in absolute ethanol.…”

Section: Bvp-lpmentioning

confidence: 99%

“…They have a size range from ~20 nm to ~5 µm in diameter, with one or more lipid bilayers surrounding aqueous compartments [23]. Liposomes have several desirable properties, such as good biodegradability and biocompatibility, prolonged release effect and enhanced chemical stability of drugs [24][25][26][27][28][29][30][31]. Phospholipid complexes, also named phytosomes, are a novel drug delivery system formed by non-covalent bonds (electrostatic interaction, van der Waals force, hydrogen bond and etc.)…”

Section: Introductionmentioning

confidence: 99%

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Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

et al. 2021

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Breviscapine (BVP), a flavonoid compound, is widely used in the treatment of cardiovascular and cerebrovascular diseases; however, the low oral bioavailability and short half-life properties limit its application. The aim of this study was to investigate the three preparations for improving its oral bioavailability: nanosuspensions (BVP-NS), liposomes (BVP-LP) and phospholipid complexes (BVP-PLC). In vitro and in vivo results suggested that these three could all significantly improved the cumulative released amount and oral bioavailability compared with physical mixture, in which BVP-PLC was the most optimal preparation with the relative bioavailability and mean retention time of 10.79 ± 0.25 (p < 0.01) and 471.32% (p < 0.01), respectively. Furthermore, the influence of drug-lipid ratios on the in vitro release and pharmacokinetic behavior of BVP-PLC was also studied and the results showed that 1:2 drug-lipid ratio was the most satisfactory one attributed to the moderate-intensity interaction between drug and phospholipid which could balance the drug loading and drug release very well.

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“…The thin-film dispersion method was used to prepare BVP-LP [24,25,27,28]. 1.0 g phospholipid and 0.25 g cholesterol were accurately weighed and dissolved in absolute ethanol.…”

Section: Bvp-lpmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

et al. 2021

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“…During the process of gastric digestion, the release rate of COSs in COSs-Lip was much higher than that of CH-COSs-Lip and SA/CH-COSs-Lip. This may be because sodium alginate can reduce the activity of pepsin, and it has been shown that chitosan in stomach acid can reduce the release of drugs [ 40 ]. Therefore, SA/CH-COSs-Lip has higher stability in gastric juice, which is conducive to the transport of more embedded COSs to the small intestine.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Caco-2 Cell Transport Assay of Chito-Oligosaccharides Nano-Liposomes Based on Layer-by-Layer Coated

et al. 2021

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Chito-oligosaccharides (COSs) were encapsulated by the film-ultrasonic method into three nano-liposomes, which were uncoated liposomes (COSs-Lip), chitosan-coated liposomes (CH-COSs-Lip), and sodium alginate (SA)/chitosan (CH)-coated liposomes (SA/CH-COSs-Lip). The physicochemical and structural properties, as well as the stability and digestive characteristics, of all three nano-liposomes were assessed in the current study. Thereafter, the characteristics of intestinal absorption and transport of nano-liposomes were investigated by the Caco-2 cell monolayer. All nano-liposomes showed a smaller-sized distribution with a higher encapsulation efficiency. The ζ-potential, Z-average diameter (Dz), and polydispersity index (PDI) demonstrated that the stability of the SA/CH-COSs-Lip had much better stability than COSs-Lip and CH-COSs-Lip. In addition, the transport of the nano-liposomes via the Caco-2 cell monolayer indicated a higher transmembrane transport capacity. In summary, the chitosan and sodium alginate could serve as potential delivery systems for COSs to fortify functional foods and medicines.

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“…Table 2 shows the values of the in vitro digestibility test for the simulated fluid gastric and simulated fluid intestinal. The pH conditions adopted in the digestibility experiments are based on possible values found in the digestive system of tropical fish [36][37][38]. It can be seen that zein/tryptophan nanofibers had a slight increase in tryptophan digestion in both gastric and intestinal fluid digests in most cases, comparing the same pH conditions [39].…”

Section: Resultsmentioning

confidence: 99%

Development of zein nanofibers for the controlled delivery of essential amino acids for fish nutrition

Silva

Fuzatto

Botrel³

et al. 2020

SN Appl. Sci.

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In the present paper, films and nanofibers of zein and zein/tryptophan were produced by casting and eletrospinning. The films and nanofibers were characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and controlled release and digestibility tests. In vitro releasing of tryptophan was evaluated using a spectrophotometer UV-Vis. Interactions between tryptophan and zein were confirmed by thermal (TGA) and spectral (FTIR) analyses. SEM micrographs provided evidence of a smooth and homogeneous structure for films and nanofibers without and with tryptophan. FTIR spectroscopy indicated seconddegree intermolecular interactions between amide groups of zein and tryptophan. X-ray analysis indicated the formation of crystals that did not interfere with the crystallization of amino acid. By in vitro release experiments, it was possible to observe that the tryptophan releasing follows nearly Korsmeyer-Peppas model for the nanofibers and Peppas-Sahlin model for films, indicating the releasing process of the nanofibers are by diffusion of the amino acid and, for films, by relaxion of polymeric chain. Finally, in vitro digestibility a considerable amount of tryptophan was observed, suggesting more access of fishes for tryptophan.

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Preparation, formation mechanism and in vitro dynamic digestion behavior of quercetin-loaded liposomes in hydrogels

Cited by 47 publications

References 49 publications

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

Characterization and Caco-2 Cell Transport Assay of Chito-Oligosaccharides Nano-Liposomes Based on Layer-by-Layer Coated

Development of zein nanofibers for the controlled delivery of essential amino acids for fish nutrition

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