Preparation in supercritical CO2 of porous poly(methyl methacrylate)–poly(l-lactic acid) (PMMA–PLA) scaffolds incorporating ibuprofen

Velasco, Diego; Benito, L.; Fernández-Gutiérrez, Mar; Román, Julio San; Elvira, Carlos

doi:10.1016/j.supflu.2010.05.012

Cited by 52 publications

(35 citation statements)

References 36 publications

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“…33 They investigated biocompatibility of their nanofibers for 7 days using fibroblasts and reported that the addition of ibuprofen supported greater cellular adhesion. 33 Canton et al also reported that HDF successfully adhered to ibuprofen loaded PLGA nanofibers; however, their PLGA nanofibers degraded within 6 days. 6 Although biodegradation is desirable for allowing normal wound regeneration, fast degradation of scaffolds may not provide adequate mechanical support for the wounded skin, nor may it allow for the long-term release of drugs incorporated in the scaffolds.…”

Section: Discussionmentioning

confidence: 99%

“…33 They investigated biocompatibility of their nanofibers for 7 days using fibroblasts and reported that the addition of ibuprofen supported greater cellular adhesion. 33 Canton et al also reported that HDF successfully adhered to FIGURE 11. Contraction of wounds with/without PLA nanofibrous scaffolds with 20 wt% ibuprofen (acellular or HEK 1 HDF seeded)bars with different letters represent significant difference (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

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Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

et al. 2015

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This article presents successful incorporation of ibuprofen in polylactic acid (PLA) nanofibers to create scaffolds for the treatment of both acute and chronic wounds. Nanofibrous PLA scaffolds containing 10, 20, or 30 wt % ibuprofen were created and ibuprofen release profiles quantified. In vitro cytotoxicity to human epidermal keratinocytes (HEK) and human dermal fibroblasts (HDF) of the three scaffolds with varying ibuprofen concentrations were evaluated and compared to pure PLA nanofibrous scaffolds. Thereafter, scaffolds loaded with ibuprofen at the concentration that promoted human skin cell viability and proliferation (20 wt %) were evaluated in vivo in nude mice using a full thickness skin incision model to determine the ability of these scaffolds to promote skin regeneration and/or assist with scarless healing. Both acellular and HEK and HDF cell-seeded 20 wt % ibuprofen loaded nanofibrous bandages reduced wound contraction compared with wounds treated with Tegaderm™ and sterile gauze. Newly regenerated skin on wounds treated with cell-seeded 20 wt % ibuprofen bandages exhibited significantly greater blood vessel formation relative to acellular ibuprofen bandages. We have found that degradable anti-inflammatory scaffolds containing 20 wt % ibuprofen promote human skin cell viability and proliferation in vitro, reduce wound contraction in vivo, and when seeded with skin cells, also enhance new blood vessel formation. The approaches and results reported here hold promise for multiple skin tissue engineering and wound healing applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 327-339, 2017.

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Section: Discussionmentioning

confidence: 99%

“…33 They investigated biocompatibility of their nanofibers for 7 days using fibroblasts and reported that the addition of ibuprofen supported greater cellular adhesion. 33 Canton et al also reported that HDF successfully adhered to FIGURE 11. Contraction of wounds with/without PLA nanofibrous scaffolds with 20 wt% ibuprofen (acellular or HEK 1 HDF seeded)bars with different letters represent significant difference (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

et al. 2015

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“…Pierre Fabre claimed a new solution to impregnate drugs that are poorly soluble into CO 2 , to reduce the duration of impregnation and to avoid the stirring since it is energy consuming. This solution consists in mixing the polymer (generally grinded polymer pharmaceutical excipients or microspheres) and the drug to physically and intimately contact the two substances, and then subjecting it to scCO 2 [109][110][111][112][113][114]. For the impregnation of implants, the polymer is placed in physical contact with the drug.…”

Section: Variation Of the Scco 2 Impregnation Processmentioning

confidence: 99%

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

Champeau

Thomassin

Tassaing

et al. 2015

Journal of Controlled Release

211

137

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“…By submitting carbon dioxide (CO 2 ) to supercritical conditions (P = 160-260 bar, T = 60°C) after certain time and then rapidly depressurize, it is also possible to fabricate porous structures that are related to the supercritical parameters and to the polymer blend composition [113]. The use of carbon dioxide (CO 2 ) to create such scaffolds has received some attention in the past.…”

Section: Porosity In Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

Serrano‐Aroca¹

2017

Acrylic Polymers in Healthcare

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Acrylic-based polymers have many currently important biomedical applications such as contact lenses, corneal prosthesis, bone cements, tissue engineering, etc. due to their excellent biocompatibility and suitable performance in mechanical properties, among many other applications. Many of these biomaterials have been approved by the US Food and Drug Administration (FDA) for various applications. However, the potential uses of these polymeric materials in the biomedical industry could be increased exponentially if some of their acrylic properties (mechanical strength, electrical and/or thermal properties, water sorption and diffusion, biological interactions, antibacterial activity, porosity, etc.) are enhanced. Thus, acrylics have been fabricated as multicomponent polymeric systems in the form of interpenetrated polymer networks or combined with other advanced materials such as fibers, nanofibers, graphene and its derivatives and/or many other kinds of nanoparticles to form composite or nanocomposite materials, which are expected to exhibit superior properties. Besides, in regenerative medicine, acrylic scaffolds need to be designed with the required extent and morphology of pores by sophisticated techniques. Even though the great advances have been achieved so far, much research has to be carried out still in order to find new strategies to improve the above-mentioned properties.

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Preparation in supercritical CO2 of porous poly(methyl methacrylate)–poly(l-lactic acid) (PMMA–PLA) scaffolds incorporating ibuprofen

Cited by 52 publications

References 36 publications

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

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