Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability
Ananthakumar Ramalingam,
Sathesh Kumar Sukumaran,
Chitra Krishnan
Abstract:Background/Aim: The purpose of this study was to design and prepare floating in situ gel to sustain Carvedilol (CVD) release and enhance oral bioavailability. Various floating in situ gel formulations of the CVD were prepared by ionic gelation method. Materials and Methods: A systematic approach in the design of the formulations was adopted, were using Hydroxypropyl Methyl Cellulose (HPMC K4M), Hydroxypropyl Methyl Cellulose (HPMC 100LV), Sodium alginate, Mimosa pudica seed mucilage and Limonia acidissima gum … Show more
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