Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography

Halldin, Christer; Stone‐Elander, Sharon; Farde, Lars; Ehrin, E.; Fasth, Karl-Johan; Långström, Bengt; Sedvall, Göran

doi:10.1016/0883-2889(86)90044-4

Cited by 172 publications

(54 citation statements)

References 13 publications

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“…In contrast to the non-reversible binding kinetics in the striatum observed with D 1 radiotracers such as SCH 23390 and NNC 756 (Halldin et al 1986;Farde et al 1987;Halldin et al 1993), [ 3 H]A69024 had a relatively rapid washout from the striatum, which is consistent with its lower affinity for D 1 receptors. This reversible binding profile suggests that A69024 may prove to be a preferable radiotracer over the currently used high affinity benzazepine radioligands for PET studies involving quantification of D 1 receptor densities.…”

Section: Discussionmentioning

confidence: 87%

Effects of Endogenous Neurotransmitters on the in vivo Binding of Dopamine and 5-HT Radiotracers in Mice

Rice

2001

Neuropsychopharmacology

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Section: Discussionmentioning

confidence: 87%

Effects of Endogenous Neurotransmitters on the in vivo Binding of Dopamine and 5-HT Radiotracers in Mice

Rice

2001

Neuropsychopharmacology

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“…11 C]SCH23390 (300 MBq) (Halldin et al, 1986) was injected into the left antecubital vein. A plaster helmet was made for each participant individually and used to fixate the head and minimize motion.…”

Section: Pet Datamentioning

confidence: 99%

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Rieckmann¹,

Karlsson²,

Fischer³

et al. 2011

J. Neurosci.

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We assess the relationship of age-related losses in striatal D1 receptor densities to age-related reductions in functional connectivity between spatially distinct cortical regions in healthy human participants. Previous neuroimaging studies have reported age-related differences in functional connectivity of the frontoparietal working memory network and the default mode network during task performance. We used functional magnetic resonance imaging and seed-based connectivity (right dorsolateral and medial prefrontal cortex) to extend these findings: Anterior-posterior connectivity of both these functional networks was reduced in older (65-75 years, n ϭ 18) compared with younger (20 -30 years, n ϭ 19) adults, whereas bilateral connectivity in prefrontal cortex was increased in older adults. Positron emission tomography with the D1 receptor ligand [ 11 C]SCH23390 was used to assess caudate D1 receptor density in the same sample. Older adults showed significantly reduced caudate D1 receptor density compared to the younger adults. Of key interest, partial correlations showed that individual differences in caudate D1 receptor density were positively associated with individual differences in dorsolateral prefrontal connectivity to right parietal cortex (BA40) and negatively with medial prefrontal connectivity to right parietal cortex (BA40 and postcentral gyrus), after controlling for age. We found no correlation of caudate D1 receptor density with anteriorposterior coupling within the default mode network or with bilateral frontal connectivity. These results are consistent with animal work that has identified a role for caudate D1 receptors in mediating information transfer between prefrontal areas and parietal cortex.

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“…The first PET radiotracer for the D 1 receptor to be introduced was the benzazepine [ 11 C]SCH 23390 (Halldin et al, 1986;Farde et al, 1987;Chipkin et al, 1988;Andersen et al, 1992). In vitro, SCH 23390 displayed only moderate D 1 to 5-HT 2A receptor selectivity (Laruelle et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in Schizophrenia

Guo

Hwang

et al. 2003

Neuropsychopharmacol

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Recent positron emission tomography (PET) studies have assessed the level of dopamine (DA) D 1 receptors in the prefrontal cortex (PFC) in patients with schizophrenia and have generated contradictory findings. In the PFC of patients with schizophrenia, the binding potential (BP) Together, these data demonstrate that the in vivo binding of these radiotracers is differentially affected by changes in endogenous DA tone, and suggest that alterations in the binding of these tracers in the PFC of patients with schizophrenia might reflect changes in D 1 receptors secondary to sustained deficit in prefrontal DA function.

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Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography

Cited by 172 publications

References 13 publications

Effects of Endogenous Neurotransmitters on the in vivo Binding of Dopamine and 5-HT Radiotracers in Mice

Effects of Endogenous Neurotransmitters on the in vivo Binding of Dopamine and 5-HT Radiotracers in Mice

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in Schizophrenia

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