Preparation of 3D flexible SERS substrates by mixing gold nanorods in hydrogels for the detection of malachite green and crystal violet

Ruan, Shuyan; Wang, Wenxi; Qiu, Liting; Yan, Xin; Peng, Zhihua; Zhu, Huina; Liu, Yunzhen; Lu, Yudong; You, Ruiyun

doi:10.1007/s00604-024-06284-6

Microchim Acta

2024

DOI: 10.1007/s00604-024-06284-6

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Preparation of 3D flexible SERS substrates by mixing gold nanorods in hydrogels for the detection of malachite green and crystal violet

Shuyan Ruan,

Wenxi Wang,

Liting Qiu

et al.

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Cited by 3 publications

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Monolithic gold saturated on nanoporous gold@mirror template for highly reliable and fast surface-enhanced Raman scattering detection

Ahmad,

Wang,

et al. 2025

Biosensors and Bioelectronics

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Monolithic gold saturated on nanoporous gold@mirror template for highly reliable and fast surface-enhanced Raman scattering detection

Ahmad,

Wang,

et al. 2025

Biosensors and Bioelectronics

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Plasmonic chitosan cross-linked dialdehyde chitosan aerogels as 3D surface-enhanced Raman scattering substrates for sensitive and reliable detection

Zhong,

Zeng,

et al. 2025

Sensors and Actuators B: Chemical

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Integrated SERS-Microfluidic Sensor Based on Nano-Micro Hierarchical Cactus-like Array Substrates for the Early Diagnosis of Prostate Cancer

Jia,

Meng,

Gao

et al. 2024

Biosensors

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The detection and analysis of cancer cell exosomes with high sensitivity and precision are pivotal for the early diagnosis and treatment strategies of prostate cancer. To this end, a microfluidic chip, equipped with a cactus-like array substrate (CAS) based on surface-enhanced Raman spectroscopy (SERS) was designed and fabricated for the detection of exosome concentrations in Lymph Node Carcinoma of the Prostate (LNCaP). Double layers of polystyrene (PS) microspheres were self-assembled onto a polyethylene terephthalate (PET) film to form an ordered cactus-like nanoarray for detection and analysis. By combining EpCAM aptamer-labeled SERS nanoprobes and a CD63 aptamer-labeled CAS, a ‘sandwich’ structure was formed and applied to the microfluidic chips, further enhancing the Raman scattering signal of Raman reporter molecules. The results indicate that the integrated microfluidic sensor exhibits a good linear response within the detection concentration range of 105 particles μL−1 to 1 particle μL−1. The detection limit of exosomes in cancer cells can reach 1 particle μL−1. Therefore, we believed that the CAS integrated microfluidic sensor offers a superior solution for the early diagnosis and therapeutic intervention of prostate cancer.

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Preparation of 3D flexible SERS substrates by mixing gold nanorods in hydrogels for the detection of malachite green and crystal violet

Cited by 3 publications

References 37 publications

Monolithic gold saturated on nanoporous gold@mirror template for highly reliable and fast surface-enhanced Raman scattering detection

Monolithic gold saturated on nanoporous gold@mirror template for highly reliable and fast surface-enhanced Raman scattering detection

Plasmonic chitosan cross-linked dialdehyde chitosan aerogels as 3D surface-enhanced Raman scattering substrates for sensitive and reliable detection

Integrated SERS-Microfluidic Sensor Based on Nano-Micro Hierarchical Cactus-like Array Substrates for the Early Diagnosis of Prostate Cancer

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