Preparation of 90Y by a 90Sr-90Y chromatographic generator using combined columns containing Sr resin and DGA resin for radionuclide therapy

Poorbaygi, Hosein; Roozbahani, Ali; Moradi, Kourosh; Habibpanah, Ali A.; Pooremad, Behnam

doi:10.1007/s10967-020-07579-7

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Selection of proper eluting agent prior to use of 90 Y 3+ for labeling and radiolysis of organic support materials is crucial and is identifed as the main limitations of current 90Sr/90Y [35,56]. Tus, the established methodology ofered a facile, better selectivity and simple approach compared to the published work [12][13][14][15][16][17][18][19][20][21]57]. Numerous eluting agents such as HNO 3 , HClO 4 , H 2 SO 4 , and acetic acid (1.0 × 10 −1 M) were checked for recovery of Y 3+ from chelated Chelex-1000 packed column.…”

Section: Possible Sorption Mechanism For Y 3+mentioning

confidence: 99%

“…In summary, the current study presented an optimized protocol for selective separation of 90 Y 3+ from 90 Sr 2+ with good purity using chelating Chelex-100 (anion exchanger) packed column. Te membrane-like structures and the available active sites of the Chelex-100 solid extractor permit good separation of Y 3+ from Sr 2+ compared to other sorbents [12][13][14][15][16][17][18][19][20][21][22]57]. Compared to previous methods for separation of 90 Y 3+ from 90 Sr, Chelex-100 requires slight sample operation to reduce the analysis time, and it does not require solvent evaporations and reconstruction step.…”

Section: Conclusion Drawbacks and Future Outlooksmentioning

confidence: 99%

“…Recently, huge volumes of radioactive wastes and a diversity of radionuclides are generated from nuclear reaction process are certainly released into the natural environment [13,14]. Tus, many approaches have been described in the last two decades for complete separation of 90 Y 3+ from various solutions via 2-ethylhexyl phosphonic acid mono-2ethylhexyl ester (PC88A) in kerosene, [15], solvent extraction [16][17][18][19][20], organic resin and chelating agent and TBPtreated resins such as amberlite XAD-4 [21][22][23][24], cation ion exchanger [25,26], pyridyl azo napthol (PAN)/zeolite composite [27], Tefon grain support di (2-ethyl hexyl) phosphoric acid-dodecane [28], Chelex-100 [29], paper chromatography [30], nafon-117, and dowex 50W X8 [31].…”

Section: Introductionmentioning

confidence: 99%

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Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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There is growing demand for separation of 90Y carrier free from 90Sr coexisting to produce high purity 90Y essential for radiopharmaceutical uses. Thus, in this context the sorption profiles of Y3+ and Sr2+ from aqueous solutions containing diethylenetriaminepenta acetic acid (DTPA), ethylenediaminetetra-acetic acid (EDTA), acetic acid, citric acid, or NaCl onto Chelex-100 (anion ion exchange) solid sorbent were critically studied for developing an efficient and low-cost methodology for selective separation of Y3+ from Sr2+ ions (1.0 × 10−5 M). Batch experiments displayed relative chemical extraction percentage (98 ± 5.4%) of Y3+ from aqueous acetic acid solution onto Chelex-100 (anion ion exchanger), whereas Sr2+ species showed no sorption. Hence, a selective separation of Y3+ from its parent 90Sr2+ has been established based upon percolation of the aqueous solution of Y3+ and Sr2+ ions containing acetic acid at pH 1-2 through Chelex-100 sorbent packed column at a 2 mL min−1 flow rate. Y3+ species were retained quantitatively while Sr2+ ions were not sorbed and passed through the sorbent packed column without extraction. The sorbed Y3+ species were then recovered from the sorbent packed column with HNO3 (1.0 M) at a 1.0 mL min−1 flow rate. A dual extraction mechanism comprising absorption associated to “weak-base anion exchanger” and “solvent extraction” of Y3+ as (YCl6)3− and an extra part for “surface adsorption” of Y3+ by the sorbent is proposed. The established method was validated by measuring the radiochemical (99.2 ± 2 1%), radionuclide purity and retardation factor (Rf = 10.0 ± 0.1 cm) of 90Y3+ recovered in the eluate. Ultimately, the sorbent packed column also presented high stability for reusing 2-3 cycles without drop in its efficiency (±5%) towards Y3+ uptake and relative chemical recovery. A proposed flow sheet describing the analytical procedures for the separation of 90Y3+ from 90Sr2+ using chelating Chelex 100 (anion exchange) packed column is also included.

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Section: Possible Sorption Mechanism For Y 3+mentioning

confidence: 99%

Section: Conclusion Drawbacks and Future Outlooksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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“…In addition to obtaining Au isotopes, it is also necessary to develop a method for their recovery from irradiated targets. Sorption materials, widely used to solve the problems of radioanalytical chemistry [ 13 , 14 ], radiochemical technologies [ 15 , 16 ], and nuclear medicine [ 17 ], were studied in several works for the separation of Au and Hg. It was established that the K d of both elements in different media on cation- and anion-exchange sorbents was either very low or very high, which did not enable quantitatively separating them from each other [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators

et al. 2022

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In our work, the photonuclear production of 198,199Au isotopes for nuclear medicine purposes was studied, and a method for their recovery from irradiated mercury was developed. The yields of the corresponding nuclear reactions were determined, and a comparison of various methods of obtaining gold radioisotopes was provided. New sorbents based on benzo-15-crown-5, which selectively binds gold, were studied, and the optimal conditions for Au recovery with a high degree of purification from mercury were found. It was established that, for the fast and quantitative recovery of Au isotopes, it was necessary to add at least 0.1 mg of the carrier. As a result, the developed method can be regularly used to obtain 198,199Au for the research of radiopharmaceuticals based on them.

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Sorption of gold(iii) from hydrochloric acid solutions by the sorbents based on benzo-15-crown-5

Dovhyi

Bezhin

2022

Russ Chem Bull

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Preparation of 90Y by a 90Sr-90Y chromatographic generator using combined columns containing Sr resin and DGA resin for radionuclide therapy

Cited by 4 publications

References 14 publications

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators

Sorption of gold(iii) from hydrochloric acid solutions by the sorbents based on benzo-15-crown-5

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