Preparation of a “Branch-Fruit” structure chitosan nanofiber physical hydrogels with high mechanical strength and pH-responsive controlled drug release properties

Abstract

Representation of the gelation mechanism of CSNF/HA/β-GP precursor solution.

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response

“…The loss angle tangent values of the four gels are all small, indicating that the synthesized gels are mainly elastic under external forces. Compared to most physically crosslinked hydrogels, the mechanical properties of the gels in this study were improved [ 54 , 55 ]. Because we added chemical crosslinking to improve the mechanical properties of the gel, compared to a portion of physicochemical double-crosslinked hydrogels, the gels in this study have a lower energy storage modulus [ 26 , 56 ]; we think this is because the addition of the pH-sensitive monomer increases the swelling of the gel, which reduces the elasticity of the gel.…”

Amphiphilic Chitosan Porous Membranes as Potential Therapeutic Systems with Analgesic Effect for Burn Care

“…The lidocaine-charged membranes tridimensional porous morphology is suitable for therapeutic applications, allowing the facile penetration of physiological fluids and the diffusion of drug molecules. At the same time, the presence of rougher walls should facilitate the cell adhesion and proliferation [ 55 ].…”

“…The capacity of the chitosan membranes to absorb physiological fluids, such as burns exudates, plays a crucial role in maintaining a moist environment over burns and also influences the drug release efficiency [ 55 ]. The swelling capacity of the chitosan-based porous membranes (charged and non-charged) was evaluated in simulated conditions (in PBS solution at 310 K), and the experimental data were displayed in Figure 6 .…”

Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters

“…Furthermore, due to its unfavorable spinnability and mechanical properties, chitosan often needs to be combined with other materials, such as polyethylene oxide (PEO) ( Hakimi et al, 2023 ), silk fibroin ( Deng et al, 2023 ), gelatin ( Campa-Siqueiros et al, 2023 ), Hyaluronic acid ( Wen et al, 2022 ), and poly (vinyl alcohol) ( Lv et al, 2022a ), to produce fibers with desirable formation characteristics. For instance, a unique drug-loaded hydrogel containing chitosan nanofiber, hyaluronic acid (HA), and β-glycerophosphate disodium (β-GP) was created by physical crosslinking, micro-dissolution, and high pH sensitivity, drawing inspiration from the structure of cell tissues.…”