Preparation of a cold kit of186Re(Sn)-HEDP

Bai, H. S.; Jin, Xiangchun; Wang, F.; Du, Jianjun; Liu, Y. M.; Chen, D. M.

doi:10.1007/bf02040040

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Formulation and Radiolabeling1

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Cited by 16 publications

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“…4). Higher amounts of carrier used with HEDP by other researchers have had no reporting of drastic changes in color [22,23].…”

Section: Formulation and Radiolabelingmentioning

confidence: 96%

Preparation of a rhenium-188 labeled bisphosphonate for bone pain palliation therapy

Erfani

Doroudi

Dinari

et al. 2014

J Radioanal Nucl Chem

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In order to reduce the pain due bone metastases a last generation bisphosphonate, 2-(3-pyridinyl)-1-hydroxyethane diphosphonic acid, was labeled with 188 Re and investigated further. Labeling was performed at 95°C for 15 min. The stability of radioconjugate was checked in human serum at 37°C and biodistribution was studied in balb/c mice. Labeling yield of C98 % was obtained corresponding to a specific activity of 46 MBq/lmol. The radioconjugate showed good stability in human serum. Our main achievement was high bone uptake (4.24 ± 0.12 % ID/g at 24 h post injection) which may therapeutically be beneficial for the palliation of painful bone metastasis.

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“…4). Higher amounts of carrier used with HEDP by other researchers have had no reporting of drastic changes in color [22,23].…”

Section: Formulation and Radiolabelingmentioning

confidence: 96%