Preparation of a Momordica charantia L. polysaccharide‑chromium (III) complex and its anti-hyperglycemic activity in mice with streptozotocin-induced diabetes

Zhang, Cong; Huang, Mao; Ri, Hong; Chen, Hong‐Man

doi:10.1016/j.ijbiomac.2018.10.200

Cited by 46 publications

(34 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been reported that metal ions react with carboxyl groups on sugars, resulting in the mutual polymerization of polysaccharide chains to form an “egg box” structure, which leads to increased molecular asymmetry and changes in molecular conformation [49]. Similar results have also been reported by Zhang et al [50]. Significant shift was not detected between the positive and negative CD spectra of the polysaccharide and its complex with chromium(III) in Momordica charantia , indicating that the 3-dimensional spiral structure of the polysaccharide was not changed by the complexing with chromium(III).…”

Section: Resultssupporting

confidence: 67%

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Liu

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricular (AAPS-iron(III)). The highest iron content (28.40%) in the AAPS-iron(III) complex was obtained under the optimized preparation conditions including an AAPS to FeCl3∙6H2O ratio of 2:3 (w/w), a pH value of 8.0 in solution, a reaction temperature of 50°C, and a reaction time of 3 h. The physical and chemical properties of the AAPS-iron(III) complex were characterized by qualitative and quantitative analyses using scanning electron microscope, particle size distribution, thermogravimetric analyzer, Fourier transform infrared spectroscopy, circular dichroism, and 1H nuclear magnetic resonance. Result showed that, although the iron was bound to the polysaccharide, it was released under artificial gastrointestinal conditions. The AAPS-iron(III) complex exhibited high stability (under 50-256°C) and water solubility. The AAPS-iron(III) complex also showed high antioxidant activity in vitro, demonstrating an additional health benefit over other typical nonantioxidant iron nutritional supplements. Furthermore, the AAPS-iron(III) complex showed high efficiency on the treatment of the iron deficiency anemia in the model rats. Therefore, the AAPS-iron(III) complex can be used as a nutritional fortifier to supply iron in industrial processing and to assist the treatment of iron deficiency anemia.

show abstract

Section: Resultssupporting

confidence: 67%

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Liu

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…al. (2011), cucurbitane triterpenoidsHarinantenaina et al (2006),Han et al (2018), polysaccharideXu et al (2015), cucurbitane saponinsYue et al (2017), saponins and polysaccharidesWang et al (2019), insulin-like peptide, charantin, alkaloid vicinePahlavani et al (2019), 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al, charantal, charantoside XI, and 25ξ-isopropenylchole-5, 6-ene-3-O-D-glucopyranoside Shivanagoudra et al (2019), polysaccharide-chromium (III) complexZhang et al (2019), saponins and polysaccharidesWang et al (2019), momordicinin Kulkarni et al (2021), Karaviloside VI and VIII Perera et al (2021), 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al Noruddin et al (2021), yeojoosides G-H, momordicoside U, karavilagenin A, goyaglycoside d, momordicoside F 1 , momordicoside L, momordicoside K, and 68 (3β,7β,23S)-3,7,23-trihydroxycucurbita-5,24-dien-19-al 7-β-D-glucopyranose Lee et al (2021). Moringa oleifera Isothiocyanate-rich Waterman et al (2016), protein (Mo-LPI) Paula et al (2017), phenolic glycosides Wang et al (2017b), 4hydroxyphenylacetonitrite, fluoropyrazine, methyl-4-hydroxybenzoate, vanillin Hafizur et al (2018) Musa x sapientum Rutin Kappel et al (2013), syringin Sundaram et al (2014) Ocimum gratissimum Chicoric acid Casanova et al (2014) Olea europaea Oleuropein, oleanolic acid Sato et al (2007), luteolin Dekdouk et al (2015) Opuntia ficus-indica Polysaccharides El-mostafa et al (2014), polyphenols, dietary minerals, betalains, gallic acid, vanillic acid, catechins Gupta et al (2017), mucopolysaccharide Bharti et al (2018) Oryza sativa γ-oryzanol Burlando and Cornara (2014), ferulic acid, p-coumaric Aalim et al (2019), cyanidin 3-glucoside, and (2R,3R)taxifolin Yoon et al (2020).…”

mentioning

confidence: 99%

Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data

et al. 2021

View full text Add to dashboard Cite

Several studies have been conducted and published on medicinal plants used to manage Diabetes Mellitus worldwide. It is of great interest to review available studies from a country or a region to resort to similarities/discrepancies and data quality. Here, we examined data related to ethnopharmacology and bioactivity of antidiabetic plants used in the Democratic Republic of Congo. Data were extracted from Google Scholar, Medline/PubMed, Scopus, ScienceDirect, the Wiley Online Library, Web of Science, and other documents focusing on ethnopharmacology, pharmacology, and phytochemistry antidiabetic plants used in the Democratic Republic of Congo from 2005 to September 2021. The Kew Botanic Royal Garden and Plants of the World Online web databases were consulted to verify the taxonomic information. CAMARADES checklist was used to assess the quality of animal studies and Jadad scores for clinical trials. In total, 213 plant species belonging to 72 botanical families were reported. Only one plant, Droogmansia munamensis, is typically native to the DRC flora; 117 species are growing in the DRC and neighboring countries; 31 species are either introduced from other regions, and 64 are not specified. Alongside the treatment of Diabetes, about 78.13% of plants have multiple therapeutic uses, depending on the study sites. Experimental studies explored the antidiabetic activity of 133 plants, mainly in mice, rats, guinea pigs, and rabbits. Several chemical classes of antidiabetic compounds isolated from 67 plant species have been documented. Rare phase II clinical trials have been conducted. Critical issues included poor quality methodological protocols, author name incorrectly written (16.16%) or absent (14.25%) or confused with a synonym (4.69%), family name revised (17.26%) or missing (1.10%), voucher number not available 336(92.05%), ecological information not reported (49.59%). Most plant species have been identified and authenticated (89.32%). Hundreds of plants are used to treat Diabetes by traditional healers in DRC. However, most plants are not exclusively native to the local flora and have multiple therapeutic uses. The analysis showed the scarcity or absence of high-quality, in-depth pharmacological studies. There is a need to conduct further studies of locally specific species to fill the gap before their introduction into the national pharmacopeia.

show abstract

“…Carbohydrates including oligosaccharides and polysaccharides extracted from herbs, fungi, and algae are effective in the treatment of several pathologies are used in the clinic ( 23 24 25 26 27 ). The prebiotic effect of arabinoxylan oligosaccharide isolated from wheat ( 28 ), antihyperglycemic effects of polysaccharide extracted from Memordica charantia ( 29 ), Inonotus obliquus ( 30 ), Hericium erinaceus ( 31 ), Ophiopogon japonicas ( 32 ), immune-modulatory effect of polysaccharide from Hibiscus sabdariffa L . ( 33 ), antioxidantive potential of polysaccharide from Euryale ferox Salisb.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats

Bahrami

Izadi

Miraghaee

et al. 2021

Research in Pharmaceutical Sciences

View full text Add to dashboard Cite

Background and purpose: Diabetes is a group of multifactorial disorders characterized by chronic-elevated blood glucose levels (hyperglycemia). Natural remedies are used as alternative medications to treat diabetes. Here, we tested the protective effect of the plant extracts of the Rosaceae family on improving insulin secretion and repairing the pancreatic beta cells in diabetic rats. Experimental approach: The oligosaccharide fraction was isolated from the Rosaceae family of herbs. LC-MS/MS was applied to characterize the isolated fractions. The male Wistar rats were randomly divided into six groups, 10 each, including the control group with no intervention, diabetic rats without treatment, diabetic rats that received the extract of Malus domestica (apple), Cydonia oblonga (quince), Prunus persica (nectarine), and Prunus persica (peach), separately. Rats were monitored for the weight, fasting plasma glucose, and insulin levels. The effect of extracts in streptozotocin (STZ)-induced diabetic rats on the pancreatic islets was evaluated by morphometric analysis. Findings/Results: LC-MS/MS results indicated a similar mass spectrum of isolated fractions from nectarine and peach with Rosa canina . Oral administration of nectarine and peach extracts to STZ-induced diabetic rats showed restoration of blood glucose levels to normal levels with a concomitant increase in insulin levels. Morphometric analysis of pancreatic sections revealed the increase in number, diameter, volume, and area of the pancreatic islets in the diabetic rats treated with extracts compared to the untreated diabetic rats. Conclusion and implications: Nectarine and peach extracts’ anti-diabetic properties improved insulin secretion and pancreatic beta-cell function and subsequently led to restoring pancreatic islet mass in STZ-induced diabetic rats.

show abstract

Preparation of a Momordica charantia L. polysaccharide‑chromium (III) complex and its anti-hyperglycemic activity in mice with streptozotocin-induced diabetes

Cited by 46 publications

References 34 publications

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data

Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats

Contact Info

Product

Resources

About