Preparation of a novel bromine complex and its application in organic synthesis

Nishio, Yuya; Yubata, Kotaro; Wakai, Yutaro; Notsu, Kotaro; Yamamoto, Katsumi; Fujiwara, Hideki; Matsubara, Hiroshi

doi:10.1016/j.tet.2019.01.055

Search citation statements

Order By: Relevance

Paper Sections

Select...

Direct α-Halogenation Of Aryl Ketones1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2023

Publication Types

Select...

Article4

Other1

Book1

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 9 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CAN demonstrated excellent catalytic activity in the α-chlorination of (a)cylic ketones [ 131 , 132 ]. This route employed the rather unconventional acetyl chloride as the chlorine source, yielding one α-chloroarylketone (i.e., 2-chloro-1-phenylethanone) in 87%.…”

Section: Direct α-Halogenation Of Aryl Ketonesmentioning

confidence: 99%

Synthetic Access to Aromatic α-Haloketones

et al. 2022

View full text Add to dashboard Cite

α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.

show abstract

Section: Direct α-Halogenation Of Aryl Ketonesmentioning

confidence: 99%