Preparation of a novel supermacroporous molecularly imprinted cryogel membrane with a specific ionic liquid for protein recognition and permselectivity

Fan, Jie; Zhang, Fengyan; Yang, Xuemeng; Zhang, Xuehong; Cao, Yijun; Peng, Hailong

doi:10.1002/app.46740

Cited by 29 publications

(11 citation statements)

References 47 publications

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“…The result confirmed that with a well-controlled pore size distribution, the graphene NATMs can outperform the commercialized polymeric membranes in both permeance and selectivity. Moreover, the selectivity of graphene NATMs was notably higher than the selectivity achieved by isoporous membranes, − molecularly imprinted cryogel membranes, silica colloidal crystal membranes, and track-etched membranes . Also, this value was comparable to the selectivity achieved in diffusion tests by gold nanotubule membranes .…”

Section: Resultsmentioning

confidence: 99%

Tunable Pore Size from Sub-Nanometer to a Few Nanometers in Large-Area Graphene Nanoporous Atomically Thin Membranes

Chen

Zhang

Hou

et al. 2021

ACS Appl. Mater. Interfaces

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Membranes are key components in chemical purification, biological separation, and water desalination. Traditional polymeric membranes are subjected to a ubiquitous trade-off between permeance and selectivity, which significantly hinders the separation performance. Nanoporous atomically thin membranes (NATMs), such as graphene NATMs, have the potential to break this trade-off. Owing to their uniqueness of two-dimensional structure and potential nanopore structure controllability, NATMs are expected to have outstanding selectivity through molecular sieving while achieving ultimate permeance at the same time. However, a drastic selectivity discrepancy exists between the proof-of-concept demonstrations and scalable separation applications in graphene membranes. In this paper, we offer a possible solution to narrow this discrepancy by tuning the pore density and pore size separately with two successive plasma treatments. We demonstrate that by narrowing the pore size distribution, the selectivity of graphene membranes can be greatly increased. Low-energy argon plasma is first applied to nucleate high density of defects in graphene. Controlled oxygen plasma is then utilized to selectively enlarge the defects into nanopores with desired sizes. This method is scalable, and the fabricated 1 cm2 graphene NATMs with sub-nanometer pores can separate KCl and Allura Red with a selectivity of 104 and a permeance of 1.1 × 10–6 m s–1. The pores in NATMs can be further tuned from gas-selective sub-nanometer pores to a few nanometer size. The fabricated NATMs show a selectivity of 35 between CO2 and N2. With longer enlargement time, a selectivity of 21.2 between a lysozyme and bovine serum albumin can also be achieved with roughly four times higher permeance than that of a commercial dialysis membrane. This research offers a solution to realize NATMs of tunable pore size with a narrow pore size distribution for different separation processes from sub-nanometer in gas separation or desalination to a few nanometers in dialysis.

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Section: Resultsmentioning

confidence: 99%

Tunable Pore Size from Sub-Nanometer to a Few Nanometers in Large-Area Graphene Nanoporous Atomically Thin Membranes

Chen

Zhang

Hou

et al. 2021

ACS Appl. Mater. Interfaces

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“…Membranes exhibited higher binding affinity with respect to those prepared without the ionic liquid. In addition, the selectivity factor for salicylic acid with respect to the competing compounds p-hydroxybenzoic acid and phenol was 5.85 and 5.90, respectively [ 278 ]. Fan and coauthors developed a macroporous cryogel-imprinted membrane using (1-vinyl-3-(2-amino-2-oxoethyl) imidazolium chloride as a functional monomer and bovine serum albumin as a model template protein [ 279 ], in a phosphate buffer as solvent and porogen.…”

Section: Green Molecularly Imprinted Membranesmentioning

confidence: 99%

“…Permeation tests carried out in a diffusion cell with solutions containing the template and the similar human serum albumin (having each one the concentration of 0.4 mg∙L −1 ) evidenced a high transport rate of the template molecules: the permeation amount of bovine serum albumin was 2.82 mg∙cm −2 , while that of the competing protein was 1.63 mg∙cm −2 [ 278 ].…”

Section: Green Molecularly Imprinted Membranesmentioning

confidence: 99%

Green Chemistry and Molecularly Imprinted Membranes

et al. 2022

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Technological progress has made chemistry assume a role of primary importance in our daily life. However, the worsening of the level of environmental pollution is increasingly leading to the realization of more eco-friendly chemical processes due to the advent of green chemistry. The challenge of green chemistry is to produce more and better while consuming and rejecting less. It represents a profitable approach to address environmental problems and the new demands of industrial competitiveness. The concept of green chemistry finds application in several material syntheses such as organic, inorganic, and coordination materials and nanomaterials. One of the different goals pursued in the field of materials science is the application of GC for producing sustainable green polymers and membranes. In this context, extremely relevant is the application of green chemistry in the production of imprinted materials by means of its combination with molecular imprinting technology. Referring to this issue, in the present review, the application of the concept of green chemistry in the production of polymeric materials is discussed. In addition, the principles of green molecular imprinting as well as their application in developing greenificated, imprinted polymers and membranes are presented. In particular, green actions (e.g., the use of harmless chemicals, natural polymers, ultrasound-assisted synthesis and extraction, supercritical CO2, etc.) characterizing the imprinting and the post-imprinting process for producing green molecularly imprinted membranes are highlighted.

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“…Thus, MIMs were used for the depletion of albumin from neat solutions and biological samples [63][64][65][66]. An interesting example is that developed by Fan et al [65], where a supermacroporous MIM was prepared via cryopolymerization using a functionalized ionic liquid {(1-vinyl-3-(2-amino-2-oxoethyl) imidazolium chloride, [VAMIM]Cl]} as functional monomer and bovine serum albumin (BSA) as the template. The preparation scheme of this imprinted membrane and the schematic representation of the molecular imprinting procedures were depicted in Figure 16.…”

Section: Pharmaceutical and Food Applicationsmentioning

confidence: 99%

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

et al. 2020

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This review describes the recent advances from the past five years concerning the development and applications of molecularly imprinted membranes (MIMs) in the field of sample treatment and separation processes. After a short introduction, where the importance of these materials is highlighted, a description of key aspects of membrane separation followed by the strategies of preparation of these materials is described. The review continues with several analytical applications of these MIMs for sample preparation as well as for separation purposes covering pharmaceutical, food, and environmental areas. Finally, a discussion focused on possible future directions of these materials in extraction and separation field is also given.

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Preparation of a novel supermacroporous molecularly imprinted cryogel membrane with a specific ionic liquid for protein recognition and permselectivity

Cited by 29 publications

References 47 publications

Tunable Pore Size from Sub-Nanometer to a Few Nanometers in Large-Area Graphene Nanoporous Atomically Thin Membranes

Tunable Pore Size from Sub-Nanometer to a Few Nanometers in Large-Area Graphene Nanoporous Atomically Thin Membranes

Green Chemistry and Molecularly Imprinted Membranes

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

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