Preparation of a Phase Diagram for Coacervation

Phares, Russell E.; Sperandio, Giulio

doi:10.1002/jps.2600530512

Cited by 9 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accounting for different phase separation mechanisms, coacervation was subdivided into simple and complex coacervation. In simple coacervation, the polymer is salted out by electrolytes, such as sodium sulfate, 30,31 or desolvated by the addition of water-miscible nonsolvents such as ethanol. 31 On the other hand, the process of complex coacervation is described as a phase-separation process which occurs in the mixture solution of oppositely charged polyions.…”

Section: Brief Overview On Pla/plga Coacervation For Drug Microencapsmentioning

confidence: 99%

Drug Microencapsulation by PLA/PLGA Coacervation in the Light of Thermodynamics. 1. Overview and Theoretical Considerations

Thomasin

Nam-Trân

Merkle

et al. 1998

Journal of Pharmaceutical Sciences

102

View full text Add to dashboard Cite

Phase separation of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA), often called "coacervation" in the pharmaceutical field, is one of the classical methods for peptide drug microencapsulation in biodegradable polyesters. Although numerous studies have used this technique, the underlying physicochemical mechanisms of polyester coacervation under conditions of microsphere production have not been well-described yet. Moreover, the quality of microencapsulation in terms of drug loading efficiency and residual organic solvents is often not entirely satisfactory and depends greatly on the specific drug and polymer used. The first part of this contribution reviews briefly the scientific and patent literature on PLA/PLGA coacervation. Then, the underlying physicochemical principles of polyester coacervation are discussed and relevant thermodynamic models presented. More specifically, attempts were made to clarify the necessary characteristics of polymers, solvents, and coacervating and hardening agents for successful phase separation and microsphere formation. These basic considerations may contribute to a better understanding of the boundary conditions crucial for efficient drug microencapsulation by polyester coacervation.

show abstract

Section: Brief Overview On Pla/plga Coacervation For Drug Microencapsmentioning

confidence: 99%