Preparation of a poly(ionic liquid)-functionalized cellulose aerogel and its application in protein enrichment and separation

Qian, Liwei; Yang, Manman; Chen, Haonan; Yang, Xu; Zhang, Sufeng; Zhou, Qiusheng; He, Bin; Bai, Yang; Song, Wei

doi:10.1016/j.carbpol.2019.04.081

Cited by 58 publications

(35 citation statements)

References 53 publications

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“…Cellulose, with an annual production of 7.5 × 10 10 tons, is one of the most abundant bio-renewable sources in the world [10]. Due to its low price, nontoxicity, edibility, and eco-friendly property, cellulose has been considered a promising biomedical material in tissue engineering [11], protein enrichment [12], wound dressings [13], and other fields. It has been reported that spherical cellulose beads with high porosity, high specific surface area, and adjustable pore size can be conveniently prepared from regenerated cellulose, and hence can be used as a potential drug carrier [14].…”

Section: Introductionmentioning

confidence: 99%

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

et al. 2021

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The development of controlled drug delivery systems based on bio-renewable materials is an emerging strategy. In this work, a controlled drug delivery system based on mesoporous oxidized cellulose beads (OCBs) was successfully developed by a facile and green method. The introduction of the carboxyl groups mediated by the TEMPO(2,2,6,6-tetramethylpiperidine-1-oxyradical)/NaClO/NaClO2 system presents the pH-responsive ability to cellulose beads, which can retain the drug in beads at pH = 1.2 and release at pH = 7.0. The release rate can be controlled by simply adjusting the degree of oxidation to achieve drug release at different locations and periods. A higher degree of oxidation corresponds to a faster release rate, which is attributed to a higher degree of re-swelling and higher hydrophilicity of OCBs. The zero-order release kinetics of the model drugs from the OCBs suggested a constant drug release rate, which is conducive to maintaining blood drug concentration, reducing side effects and administration frequency. At the same time, the effects of different model drugs and different drug-loading solvents on the release behavior and the physical state of the drugs loaded in the beads were studied. In summary, the pH-responsive oxidized cellulose beads with good biocompatibility, low cost, and adjustable release rate have shown great potential in the field of controlled drug release.

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Section: Introductionmentioning

confidence: 99%

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

et al. 2021

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“…Cross-linked CNC/polysilsesquioxane showed high adsorption capacity for both water and toluene [217]. Poly(ionic liquid) was used to modify cellulose aerogels via Schiff base reaction enabling applications like proteomic analysis, medical diagnosis and sensors [218]. Cellulose based catalyst with good reusability was suggested in [219].…”

Section: Functionalization As a Tool To Enhance The Properties Of Ligmentioning

confidence: 99%

Biorefinery Approach for Aerogels

et al. 2020

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According to the International Energy Agency, biorefinery is “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (fuels, power, heat)”. In this review, we survey how the biorefinery approach can be applied to highly porous and nanostructured materials, namely aerogels. Historically, aerogels were first developed using inorganic matter. Subsequently, synthetic polymers were also employed. At the beginning of the 21st century, new aerogels were created based on biomass. Which sources of biomass can be used to make aerogels and how? This review answers these questions, paying special attention to bio-aerogels’ environmental and biomedical applications. The article is a result of fruitful exchanges in the frame of the European project COST Action “CA 18125 AERoGELS: Advanced Engineering and Research of aeroGels for Environment and Life Sciences”.

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“…Protein molecularly imprinted polymers (MIPs) are functionally polymeric materials that specifically recognize template proteins . Thus far, MIPs have shown wide application prospects in many fields, such as chemical bionic sensors , protein separation , natural antibody simulation , and drug sustained release . However, the protein bio‐macromolecules of the corresponding MIPs are disadvantaged by weak specificity of the functional groups, large size, and flexible conformations, which challenge their design and preparation .…”

Section: Introductionmentioning

confidence: 99%

“…Protein molecularly imprinted polymers (MIPs) are functionally polymeric materials that specifically recognize template proteins [1,2]. Thus far, MIPs have shown wide application prospects in many fields, such as chemical bionic sensors [3,4], protein separation [5][6][7], natural antibody simulation [8][9][10], and drug sustained release [11,12]. However, the protein bio-macromolecules of the corresponding MIPs are disadvantaged by weak specificity of the functional groups, large size, Article Related Abbreviations: IF, Imprinting factor; LCST, lower critical solution temperature; MCS, modified chitosan; MIPs, Protein molecularly imprinted polymers; NIPAM, N-isopropylacrylamide; NIPs, Non-imprinted polymer microspheres; Q, Adsorption amount (mg/g); SBMA, sulfobetaine methacrylate; β, selection factor.…”

Section: Introductionmentioning

confidence: 99%

Thermo‐sensitive surface molecularly imprinted magnetic microspheres based on bio‐macromolecules and their specific recognition of bovine serum albumin

Wang

Zhou

et al. 2020

J of Separation Science

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Bovine serum albumin imprinted magnetic microspheres, with functional monomers of modified chitosan, N‐isopropylacrylamide and sulfobetaine methacrylate, were successfully prepared and characterized in detail. Computational analyses showed that during the preparation process, modified chitosan can effortlessly form multiple non‐covalent bonds with protein molecules. Temperature‐sensitive N‐isopropylacrylamide improves the elution efficiency by abating the mass transfer resistance. Meanwhile, the zwitterionic sulfobetaine methacrylate strongly interacts with H2O molecules, remarkably reducing the non‐specific adsorption. The specific bovine serum albumin adsorption performances of the prepared imprinted material were then determined. The adsorption amount reached 86.87 mg/g and the imprinting factor was 6.49. These excellent specific adsorption properties are attributed to the synergetic effects of the different monomers. The fabricated imprinted material not only exhibits great prospects as a biosensor or separation material for protein molecules, but also provides a collaborative strategy for preparing multi‐functional imprinted materials.

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Preparation of a poly(ionic liquid)-functionalized cellulose aerogel and its application in protein enrichment and separation

Cited by 58 publications

References 53 publications

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

Biorefinery Approach for Aerogels

Thermo‐sensitive surface molecularly imprinted magnetic microspheres based on bio‐macromolecules and their specific recognition of bovine serum albumin

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