Preparation of a push–pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core–shell structure

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

“…This may be compared to almost a 500 % increment in diameter for unmodified MSN, during the same period [121]. SNP/MSN core-shell structures have been proposed as osmotic pumps, adding PEG as excipient into the tablet formulation [82]. A remarkable zero-order release profile is achieved, although no clear explanation is provided for the SNP core (since drug loading is made after MSN shell) and loading capacities and efficiencies are not reported.…”

“…Core-shell structures, i.e., an hydrophobic core serving as reservoir for the water-insoluble molecules and an outer shell protecting the nanocarriers from clearance in bloodstream, could improve the bioavailability of these drugs [81]. Some novel MSN composites have proved to be a good choice for the solubilization of hydrophobic drugs to prepared push-pull osmotic pumps [82], in order to avoid multidrug resistance in anticancer drugs [83], or for oral delivery administration [84].…”

Preparation of starch macrocellular foam for increasing the dissolution rate of poorly water-soluble drugs

“…The remaining precipitate was washed twice with anhydrous ethanol and water and dried at 40 C for 12 h in a vacuum oven (DZF6050, Shanghaiboyuan, Shanghai, China). The obtained solid was composed of silicon nanospheres (SNS) 30 .…”

“…NDP-SMF containing an equivalent of 10 mg NDP was dissolved in 1000 mL dissolution medium 31 . Samples of the dissolution medium (5 mL) were taken at predetermined times (5,10,15,20,30,45 and 60 min) and replaced with fresh release medium (5 mL) to keep the volume of the dissolution medium constant. The NDP content was measured at a wavelength of 238 nm using UV.…”

Development of a novel starch with a three-dimensional ordered macroporous structure for improving the dissolution rate of felodipine

“…Micronization of insulin by high pressure homogenization, not only increased its bioavailability but also maintained the stability and biological activity of insulin [8]. In recent years, an increased number of researchers had focused on using nanomaterials to improve the dissolution rate of insoluble drugs [9][10][11][12][13][14][15], such as mesoporous silica nanomaterials [16][17][18][19][20][21] and carbon nanomaterials [22][23][24]. However, inorganic materials have unpredictable biological safety and are not very biodegradable [25][26][27][28].…”