Preparation of a thermo-responsive drug carrier consisting of a biocompatible triblock copolymer and fullerene

Abstract

Water-soluble C70/triblock copolymer complexes can be used as carriers that release encapsulated drugs when heated and as photosensitizers for photodynamic therapy.

Diblock Copolymers of Methacryloyloxyethyl Phosphorylcholine and Dopamine Methacrylamide: Synthesis and Real-Time Adsorption Dynamics by SEIRAS and RAIRS

“…Diblock copolymers with unprotected catechol groups pMPC-b-pDOPMA were obtained by the removal of acetonide protective groups. 1 H NMR spectra confirmed the full deprotection of catechol moieties with no side products (Figure 3, the disappearance of the acetonide −C(CH 3 ) 2 signal at 1.5 ppm).…”

“…Such a behavior is characteristic for amphiphilic diblock copolymers in solutions with the preferential solvation of one block. 61,62 To ascertain the possible micellization of the diblock copolymers in aqueous solutions, 1 H NMR spectra of the diblock copolymers in D 2 O solutions at various concentrations were recorded (Figure S12 in the the SI). These spectra were then used to calculate the DOPMA (ADOPMA) content in the copolymers (Table S3 in the SI).…”

“…Biocompatible polymers can be applied in biological systems and perform their provided functions without excessive negative responses from the system. Among biocompatible polymers, a polymer family based on the monomer 2-methacryloyloxyethyl phosphorylcholine (MPC), has exclusive importance for both fundamental studies and applications. − MPC polymers are synthetic phospholipid polymers with zwitterionic phosphorylcholine head groups, which can form cell-membrane-like structures on surfaces of various materials. , This special surface structure has a unique property to prevent nonspecific protein adsorption and to provide efficient lubrication.…”

Nonionic star polymers with upper critical solution temperature in aqueous solutions

“…Linear PUEM polymers were also incorporated within diblock copolymers to form UCST micelles for controlled drug delivery applications. [37][38][39] However, temperature-responsive star PUEM polymers remained unexplored. Using polymers with varied number of arms and matched molecular weight, we have studied the dependence of UCST transitions on the polymer branching and the presence of a small hydrogen bonding competitordimethyl sulfoxide (DMSO).…”