Preparation of amino acid ester substituted polyphosphazene microparticles via electrohydrodynamic atomization

Xue, Liwei; Mao, Lixin; Cai, Qing; Yang, Xiaoping; Jin, Riguang

doi:10.1002/pat.1711

Cited by 18 publications

(7 citation statements)

References 27 publications

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“…Microspheres were very irregular and displayed a wrinkled surface. In fact, it has been indicated that particles tend to collapse giving rise to a raisin-like morphology when low solute concentration are employed [53]. A solid PBS shell is expected to be formed as a consequence of the rapid evaporation of the solvent.…”

Section: Optimization Of Operational Conditions For Electrospraying Omentioning

confidence: 99%

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Murase

Aymat

Calvet

et al. 2015

European Polymer Journal

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Electrospraying of poly(butylene succinate) and its mixture with different indole derivatives was successfully performed using chloroform as solvent and relatively low flow rates and concentrations. Morphology of particles (size, diameter distribution and surface texture) and encapsulation efficiency were dependent on the loaded drug and specifically on the type of substituent (methyl or phenyl) and its position in the indole core. In general, particles showed a raisin-like morphology caused by the shell collapsing of the resulting structurally weak microspheres. Accumulation of electrosprayed particles gave rise to consistent mats and they had a more hydrophobic surface than that determined for smooth films. The increase of hydrophobicity was mainly dependent on the porosity and the hydrophobic nature of the incorporated drugs. Indole derivatives were hardly delivered in a standard phosphate saline buffer due to their scarce solubility in aqueous media but the addition of ethanol caused a drastic change in the release behavior. This was generally characterized by a fast burst effect and followed by the establishment of an equilibrium condition that was dependent on the indole derivative. However, a clearly different behavior was found when the indole was unable to form hydrogen bonds (e.g. 1-methylindole) since in this case a slow and sustained release was characteristic. Microspheres loaded with indole derivatives showed a high antiproliferative activity that was dependent on encapsulation efficiency and the type of loaded drug. The best results were specifically attained for the indole with an aromatic substituent. Interestingly significant differences were found between cancer and immortalized cells, a feature that points out the potential use of such systems for cancer prevention and treatment. (C) 2015 Elsevier Ltd. All rights reserved.Postprint (author's final draft

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Section: Optimization Of Operational Conditions For Electrospraying Omentioning

confidence: 99%

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Murase

Aymat

Calvet

et al. 2015

European Polymer Journal

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“…Polymer chains have more time to diffuse and rearrange in the droplet, generating a more homogeneous surface and dense particle. In addition to volatility, the multiple other properties discussed for SDD as the total molecular diffusivity related to the molecular weight, solvent quality, polymer concentration, etc., determine the final morphology [ 245 ].…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

et al. 2020

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Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.

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“…This kind of synthetic flexibility endows polyphosphazenes with tunable physical and chemical properties. The tunable physicochemical and biocompatible properties of polyphosphazenes make them promising in different biotechnological applications, such as drug delivery, biosensors, scaffolding materials and controlled release [25][26][27]. Moreover, polyphosphazene-based materials have been reported to be efficient supports in enzyme immobilization practices.…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Activity of Lipase on Polyphosphazene-Modified Polypropylene Membrane Surface

et al. 2016

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Abstract:In this work, poly(n-butylamino)(allylamino)phosphazene (PBAP) was synthesized and tethered on polypropylene microporous membrane (PPMM) with the aim of offering a biocompatible and, at the same time, moderately hydrophobic microenvironment to lipase for the first time. Lipase from Candida rugosa was used and the influence of membrane surface conditions on the activities of immobilized lipases was evaluated. Water contact angle measurement as well as field emission scanning electron microscopy were used to characterize the morphology of the modified membranes. The results showed an improvement in the adsorption capacity (26.0 mg/m 2 ) and activity retention (68.2%) of the immobilized lipases on the PBAP-modified PPMM. Moreover, the lipases immobilized on the modified PPMM showed better thermal and pH stability.

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Preparation of amino acid ester substituted polyphosphazene microparticles via electrohydrodynamic atomization

Cited by 18 publications

References 27 publications

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

Adsorption and Activity of Lipase on Polyphosphazene-Modified Polypropylene Membrane Surface

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