Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants

Zhang, Ji‐Yao; Shen, Zhigang; Zhong, Jie; Hu, Tingting; Chen, Jianfeng; Ma, Zhong-Qing; Yun, Jimmy

doi:10.1016/j.ijpharm.2006.05.048

Cited by 141 publications

(68 citation statements)

References 19 publications

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“…There is a tendency towards precipitation or agglomeration to reduce the enlarged surface area, which usually need to be resisted by adding surfactants or stabilizers, 18 so that drug loadings of 86% (weight of itraconazole/total solid weight) for sub-300 nm itraconazole nanoparticles have been considered to be high. 19 There are only a few studies about the use of naked nanocrystals in the pharmaceutical industry to date, [20][21][22][23][24] and most of the relevant research has only involved the preparation method. Wang et al 23 and Sun et al 24 prepared naked nanocrystals of different sizes with coenzyme Q 10 using the solvent/nonsolvent method and studied the relationship between particle size and solubility in four ethanol-water solutions.…”

Section: Introductionmentioning

confidence: 99%

Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals

Sun¹,

Wang²,

Sui³

et al. 2012

IJN

101

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In this paper work, four naked nanocrystals (size range 80–700 nm) were prepared without any surfactant or polymer using the solvent/nonsolvent method. The effects of particle size on their solubility, dissolution, and oral bioavailability were investigated. Solubility and dissolution testing were performed in three types of dissolution medium, and the studies demonstrated that the equilibrium solubilities of coenzyme Q 10 nanocrystals and bulk drugs were not affected by the dissolution media but the kinetic solubilities were. Kinetic solubility curves and changes in particle size distribution were determined and well explained by the proposed solubilization model for the nanocrystals and bulk drugs. The particle size effect on dissolution was clearly influenced by the diffusion coefficients of the various dissolution media, and the dissolution velocity of coenzyme Q 10 increased as particle size decreased. The bioavailability of coenzyme Q 10 after oral administration in beagle dogs was improved by reducing the particle size. For 700 nm nanocrystals, the AUC 0–48 was 4.4-fold greater than that for the coarse suspensions, but a further decrease in particle size from 700 nm to 120 nm did not contribute to improvement in bioavailability until the particle size was reduced to 80 nm, when bioavailability was increased by 7.3-fold.

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Section: Introductionmentioning

confidence: 99%

Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals

Sun¹,

Wang²,

Sui³

et al. 2012

IJN

101

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show abstract

“…Higher solute molecules in solution results in higher viscosity which in turn hinders the diffusion of nuclei between the solvent and the antisolvent phases. [29][30] Existing of large number of nuclei and decreased their diffusion lead to increase the collision rate of nuclei with each other and consequently the particle aggregation. Wide particle size distribution and presence of coarse particle (>400µm) in the samples prepared with CLX solution concentration of 20 mg/ml, as can be seen in Figure S1 (supplementary file), confirmed the particle aggregation in these samples.…”

Section: Effects Of Experimental Parameters On the Particle Sizementioning

confidence: 99%

Surfactant Free Preparation of Celecoxib Microcrystals by a Controlled Precipitation Process

Mardani¹,

Maghsoodi²,

Hamishehkar³

2017

Pharm Sci

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“…8 Mechanical commutation methods need high-energy input and show some disadvantages in practice like electrostatic effects, broad particle size distributions. 9 Supercritical fluid technique is attractive methods for size reduction, providing particles with narrow size distribution. But, they also have limitations of low yield and high equipment cost.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles

chavan¹,

Shete²,

Janugade³

et al. 2016

IJPER

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The objectives of present investigation were to prepare and evaluate nanoparticles of Olmesartan medoxomil (OLM) by a precipitation method using polyvinyl alcoholpolyethylene glycol graft copolymer (Kollicoat IR) and to investigate the effect of stirring speed & time on particle size. Particles were characterized for drug content, FTIR, zeta potential (ZP), particle size distribution (Dynamic light scattering), differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), solubility, in vitro release and stability studies. All batches showed drug content in range of 93.24 ± 0.96% to 99.91 ± 0.98%, particle size in range of 136.3-188.9 nm. As stirring speed increased particles of reduced size obtained and vice versa. ZP values of formulations were from -2.28 mV to -17.90 mV & comply with requirement of ZP for stability. Solubility results indicated improvement in solubility of formulations. PXRD analysis showed particles were in same crystalline state as raw OLM. Particle exhibited enhanced dissolution compared to raw material due to reduction in particle size, increased surface area & solubility. When formulated in tablets showed improvement in dissolution, compared to marketed formulation, anti solvent precipitation method is promising tool to prepare OLM particles by using Kollicoat IR as a polymer, for enhancement of solubility, dissolution velocity of OLM.

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Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants

Cited by 141 publications

References 19 publications

Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals

Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals

Surfactant Free Preparation of Celecoxib Microcrystals by a Controlled Precipitation Process

Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles

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