PREPARATION OF AMPHIPHILIC COMB-POLYMER PASP-Na-&lt;I&gt;g&lt;/I&gt;-DDA AND EFFECT OF GRAFTING LEVEL ON MICELLAR BEHAVIOR IN WATER SOLUTION

孙婷,; 杨伯涵,; 李昆,; 李亚鹏,; 王静媛,

doi:10.3724/sp.j.1105.2011.10242

Cited by 1 publication

(1 citation statement)

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“…The reaction of PSI with DDA was carried out for the purpose of introducing a hydrophobic group into the PSI chain. Our previous work 40 had demonstrated that when the molar ratio of DDA and succinimide units was 1 : 4, the content of hydrophobic groups was suitable for the polymer to serve as a proper surface coating for the encapsulation of QDs. Fig.…”

Section: Synthesismentioning

confidence: 99%

Optimizing conditions for encapsulation of QDs by varying PEG chain density of amphiphilic centipede-like copolymer coating and exploration of QDs probes for tumor cell targeting and tracking

Sun

et al. 2012

New J. Chem.

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Quantum dots (QDs) are potential probes for cell labeling and tracking. But the design of safe and tumor cell-sensitive probes together with high luminescent efficiency is still challenging. In this study, a novel class of biodegradable amphiphilic centipede-like copolymers was synthesized for QDs surface modification, which transformed hydrophobic QDs into hydrophilic ones. A systematic study was carried out to find how poly(ethyleneglycol) (PEG) chain density of the polymer coating influenced the properties of QDs nanocomposites, including particle size, optical properties and morphology. Results indicated that when the PEG grafting level was 40%, QDs nanocomposites showed the smallest size (105 nm), and simultaneously exhibited superior fluorescent properties among all the nanocomposites. These shell-core spherical structural nanoparticles were well dispersed in water, and did not form large aggregates. Apparently, a polymer with a PEG chain density of 40% was the optimum surface coating for QDs. These nanocomposites with outstanding capabilities can be further designed to target liver cancer cells with vascular endothelial growth factor receptor (VEGFR) overexpressed. We have evaluated QD-anti-vascular endothelial growth factor (VEGF) bioconjugates and QDs nanocomposites without anti-VEGF in live cell imaging experiments and results showed that the targeting capability to HepG2 cells of QD-anti-VEGF bioconjugates was more significant than that of nonanti-VEGF QDs. Our results provide a basis for the optimization of the polymer coating of QDs and are important for the design and development of nanoprobes for optical detection and bioimaging of tumor cells.

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Section: Synthesismentioning

confidence: 99%