Preparation of anticancer micro-medicine based on quinoline and chitosan with pH responsive release performance

Tian, Xiaohan; Zhang, Jie; Zhang, Fan; Zhao, Mengen; Chen, Zhenhua; Zhou, Kang; Zhang, Peng; Ren, Xiuli; Jiang, Xiaoqian; Mei, Xifan

doi:10.1016/j.colsurfb.2018.02.052

Cited by 19 publications

(6 citation statements)

References 44 publications

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“…On the other hand, at pH 5.4, the release rates are a little higher than that of pH 7.4 and all loaded Imatinib molecules release within 120 min. It means that the drug release rate of Fe 3 O 4 @CS/Imatinib is pH dependent and lower pH levels lead to faster release of Imatinib from this nanocomposite. It should be noted that, compared with the release behavior of the other Fe 3 O 4 @CS/drug nanocomposites, the Fe 3 O 4 @CS/Imatinib NPs do not involve any burst phenomenon at the beginning of the release trials.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Ghezeli

Hekmati

Veisi

2019

Applied Organom Chemis

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Targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy. In this respect, Imatinib‐loaded chitosan‐modified magnetic nanoparticles were prepared as a pH sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field. The proposed magnetic nanoparticles were prepared through modification of magnetic Fe3O4 nanoparticles with chitosan and Imatinib. The structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy‐dispersive X‐ray spectroscopy (EDS), field emission scanning electron microscopy (FESEM), Fourier‐transform infrared (FTIR) spectroscopy, high resolution transmission electron microscopy (HR‐TEM), vibrating sample magnetometry (VSM), X‐ray diffraction (XRD) and X‐ray photoelectron spectroscopy (XPS). UV/visible spectrophotometry was used to measure the Imatinib contents. Thermal stability of the prepared particles was investigated and their efficiency of drug loading and release profile were evaluated. The results demonstrated that Fe3O4@CS acts as a pH responsive nanocarrier in releasing the loaded Imatinib molecules. Furthermore, the Fe3O4@CS/Imatinib nanoparticles displayed cytotoxic effect against MCF‐7 breast cancer cells. Results of this study can provide new insights in the development of pH responsive targeted drug delivery systems to overcome the side effects of conventional chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Ghezeli

Hekmati

Veisi

2019

Applied Organom Chemis

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“…Chitosan which has been approved by Food and Drug Administration (FDA) is a compatible biomaterial because of its non-cytotoxicity, biocompatibility, biodegradability, and antibacterial characteristic [75,76]. Also, chitosan has amino groups and secondary and primary hydroxyl groups for the copolymer synthesis [77]. Chitosan is a temperature and pH responsive hydrogel and is soluble in weak acid and low temperature [77,78,79].…”

Section: Treatment For Degenerative Ivdmentioning

confidence: 99%

“…Also, chitosan has amino groups and secondary and primary hydroxyl groups for the copolymer synthesis [77]. Chitosan is a temperature and pH responsive hydrogel and is soluble in weak acid and low temperature [77,78,79]. Thus, there are many chitosan-based hydrogels to treat IVD, especially the NP, because of thermoresponsive characteristic of chitosan for less invasive treatment.…”

Section: Treatment For Degenerative Ivdmentioning

confidence: 99%

Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers

2019

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Intervertebral disc (IVD) is the fibrocartilage between the vertebrae, allowing the spine to move steadily by bearing multidirectional complex loads. Aging or injury usually causes degeneration of IVD, which is one of the main reasons for low back pain prevalent worldwide and reduced quality of life. While various treatment strategies for degenerative IVD have been studied using in vitro studies, animal experiments, and clinical trials, there are unsolved limitations for endogenous regeneration of degenerative IVD. In this respect, several tissue engineering strategies that are based on the cell and scaffolds have been extensively researched with positive outcomes for regeneration of IVD tissues. Scaffolds made of functional polymers and their diverse forms mimicking the macro- and micro-structure of native IVD enhance the biological and mechanical properties of the scaffolds for IVD regeneration. In this review, we discuss diverse morphological and functional polymers and tissue engineering strategies for endogenous regeneration of degenerative IVD. Tissue engineering strategies using functional polymers are promising therapeutics for fundamental and endogenous regeneration of degenerative IVD.

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“…The detailed staining steps were in accordance with our previous work. [18][19][20] Gram-positive Staphylococcus aureus (S. aureus, ATCC 35696) was chosen. S. aureus was cultured at 37°C in a liquid Luria-Bertani medium at 300 rpm in a rotary shaker with and without Lys@CaCO 3 MSs for a certain amount of time.…”

Section: Cell and Antibacterial Experimentsmentioning

confidence: 99%

Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection

Chen

Zhao

Zhang

et al. 2018

IJN

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IntroductionTreatment of infection within bone is difficult, and conventional surgical treatment brings intense pain to the patients physically and mentally. There is an urgent need to develop injectable nano- and/or micro-medicine for minimally invasive treatment of osteomyelitis.MethodsIn this paper, amino acid (L-lysine [Lys]) was mineralized into yolk-shell structured CaCO3 microspheres (MSs). The morphologies of the obtained MSs were investigated by scanning electron microscopy and transmission electron microscopy. The composition of CaCO3 MSs was identified by using Fourier transform infrared spectroscopy. The as-prepared CaCO3 MSs were examined with power X-ray diffraction analysis to obtain the crystallographic structure of the MSs.ResultsThe as prepared Lys encapsulated CaCO3 MSs (Lys@CaCO3 MSs) were used as micro-drug to improve acidic environment of osteomyelitis caused by bacterial infection and promote osteoblast proliferation under oxidative stress. These pH responsive Lys@CaCO3 MSs have a drug loading efficiency of 89.8 wt % and drug loading content (DLC) of 22.3 wt %.ConclusionOur results demonstrated that Lys@CaCO3 MSs can effectively kill Staphylococcus aureus and promote proliferation and differentiation of osteoblasts under stimulation of H2O2 at pH = 5.5.

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Preparation of anticancer micro-medicine based on quinoline and chitosan with pH responsive release performance

Cited by 19 publications

References 44 publications

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers

Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection

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