2022
DOI: 10.3390/pr10071330
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Preparation of Aqueous Propolis Extracts Applying Microwave-Assisted Extraction

Abstract: Water-based propolis extracts usually contain up to 10-fold lower quantities of active ingredients due to poor solubility in water of propolis bioactive compounds when compared with ethanol-based extracts. Since ethanol-based extracts are of limited use, water-based extracts are preferred nowadays. The application of alternative extraction techniques should be evaluated to improve extraction efficiency. Aqueous propolis extracts were prepared using purified water and propylene glycol, 2-hydroxypropyl-beta-cycl… Show more

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Cited by 9 publications
(6 citation statements)
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“…Aqueous extracts of propolis usually contain up to 10 times lower amounts of active ingredients than alcoholic extracts due to the poor solubility of propolis and its bioactive compounds [29]. The water solubility of propolis samples from the regions of Romania varies between 8.26 and 13.43%, having values close to those obtained for Indian propolis, which varies from 8.71 to 19.28% [30].…”
Section: Discussionmentioning
confidence: 92%
“…Aqueous extracts of propolis usually contain up to 10 times lower amounts of active ingredients than alcoholic extracts due to the poor solubility of propolis and its bioactive compounds [29]. The water solubility of propolis samples from the regions of Romania varies between 8.26 and 13.43%, having values close to those obtained for Indian propolis, which varies from 8.71 to 19.28% [30].…”
Section: Discussionmentioning
confidence: 92%
“…Due to the limited solubility of propolis bioactive compounds in water, water‐based propolis extracts typically contain up to 10 times fewer active ingredients than their ethanol‐based counterparts. Hence the extraction of propolis with water may be assisted by other tools, substances, or modifications of the method (temperature, time, and technique) to obtain more active ingredients (Juodeikaitė et al, 2022; Kubiliene et al, 2015; Šuran et al, 2021). Like ethanol solution propolis extracts, the concentrations can be adjusted according to the ratio and extraction time and temperature varies in different studies.…”
Section: Formulations and Application Methods Of Propolis In Burn Tre...mentioning
confidence: 99%
“…Hence the extraction of propolis with water may be assisted by other tools, substances, or modifications of the method (temperature, time, and technique) to obtain more active ingredients (Juodeikaitė et al, 2022;Kubiliene et al, 2015;Šuran et al, 2021).…”
Section: Different Forms Of Propolis Extracts (Solvents)mentioning
confidence: 99%
“…For example, a serial of flavone and phenolic acid compounds, which are responsible for its physiological activities had better be monitored pre-or after the purification. [6] Currently, extraction, isolation and purification approaches for propolis are diverse, [7,8] including traditional organic solvents extraction, [9] subcritical water extraction, [10] deep eutectic solvents extraction, [11] macro-porous resin enrichment, [12] ultrasound extraction, [13] microwave assisted extraction [14] and supercritical fluid extraction. [15] In addition to these methods, membrane-based ultrafiltration is highly suitable for natural products as it does not require heating, preventing deactivation of many natural molecules.…”
Section: Introductionmentioning
confidence: 99%