Preparation of bio-nano bandage from quince seed mucilage/ZnO nanoparticles and its application for the treatment of burn

Darvishi, Elahe; Kahrizi, Danial; Arkan, Elham; Hosseinabadi, Somayeh; Nematpour, Najmeh

doi:10.1016/j.molliq.2021.116598

Cited by 20 publications

(5 citation statements)

References 24 publications

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“…Previous studies have confirmed that these kinds of cells are the main effector cells in the pathological process of hypertrophic scar (28). Changes in its biological behavior, such as changes in its ability to proliferate, migrate, and contract, can have an important impact on the formation and remodeling of the extracellular matrix during wound healing, leading to the formation of hypertrophic scar (1,29,30). Phenotypically, triamcinolone acetonide concentration dependently suppressed the proliferation, invasion, and migration of hHSFs in vitro.…”

Section: Discussionmentioning

confidence: 86%

Triamcinolone acetonide suppressed scar formation in mice and human hypertrophic scar fibroblasts in a dose-dependent manner

Zhangqiang Wu,

Daoqiang Huang,

Jiashui Xie

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Section: Discussionmentioning

confidence: 86%

Triamcinolone acetonide suppressed scar formation in mice and human hypertrophic scar fibroblasts in a dose-dependent manner

Zhangqiang Wu,

Daoqiang Huang,

Jiashui Xie

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…The reason may be that rhBMP-2 plays an important role. rhBMP-2 is an essential component of the signal pathway that controls bone defect repair (25)(26).…”

Section: Comparison Of Results Of General Observation and Growth Of B...mentioning

confidence: 99%

Comparison of the Effects of 3D Printing Bioactive Porous Titanium Alloy Scaffolds and Nano-biology for Direct Treatment of Bone Defects

Wang¹,

Li²,

Liu³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study was to compare the effects of three-dimensional (3D) printed bioactive porous titanium alloy scaffolds (3DP-BPTAS) and rhBMP-2/PLA-loaded sustained-release nanospheres (SRNs) in the treatment of bone defects. In this study, the bioactive porous titanium alloy scaffolds (BPTAS) with different pore sizes were prepared by selective laser melting (SLM) technology. The rhBMP-2/PLA SRNs were prepared by the double emulsion solvent volatilization method. The morphology of the two nanomaterials was observed under a scanning electron microscope (SEM). The encapsulation rate (ER), drug loading (DL), and in vitro release rate of the SRNs were detected by enzyme-linked immunosorbent assay (ELISA); and the effects of different particle sizes of BPTAS and SRNs on the proliferation of BMSCs were measured using the Methyl Thiazolyl Tetrazolium (MTT) method. 42 healthy male rabbits were selected and rolled into a control group (no treatment), a model group (the femoral condyle defect model), an A800 group (model + 800 μm of BPTAS), and an A1000 group (model + 1000 μm of BPTAS), an A1200 group (model + 1200 μm of BPTAS), an A1500 group (model + 1500 μm of BPTAS), and an SNR group (model + rhBMP-2/PLA SRNs). There were 6 rabbits in each group, and they were sacrificed 4, 8, and 12 weeks after the surgery. They were performed with general observation, X-ray photography, and histological and biomechanical examinations. According to the Lane-Sandhu bone defect repair tissue X-ray and histological scoring standard, the effect of bone defect repair was evaluated. It was found that the actual pore structure of the scaffold prepared by the SLM process was consistent with the theoretical design. The observation under TEM showed that rhBMP-2/PLA SRNs were approximately round, with an average particle size of 835 nm, and its encapsulation efficiency and drug loading rate were 89.02 ± 5.14% and 0.033 ± 0.004%, respectively. The rhBMP-2/PLA SRNs and BPTAS had no statistically obvious increase in the number of cells after cell treatment compared with the control group (P> 0.05). At 12 weeks postoperatively, the stent bone tissue growing distance (SBTGD) in the SRN group was longer than that in the A1000 group (P< 0.01), and that in the A1000 group was better in contrast to the A800, A1200, and A1500 groups (P< 0.01). The Lane-Sandhu X-ray score of the SRN group was better than other groups (P< 0.05). It suggested that 3DP-BPTAS and rhBMP-2/PLA SRNs could repair the bone defects, and rhBMP-2/PLA SRNs were more conducive to the formation of new bone tissue.

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“…Compared with the model group, the myocardial infarction area (NA/AAR%) and no-reflow (ANR/AAR%) of the adenosine group and nicorandil group were significantly reduced (P<0.01). It shows that nicorandil and adenosine can reduce the area of myocardial infarction, improve coronary perfusion after myocardial infarction, and increase the ratio of myocardial reflow after myocardial reperfusion (29)(30)(31)(32)(33)(34)(35)(36)(37)(38).…”

Section: Comparison Of Ischemia-reperfusion Injurymentioning

confidence: 99%

CoO Nanoparticles Combined with MRI: Analysis of No-Reflow in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI and the Effect of Coronary Nicorandil

Liang¹,

Li²,

Xie³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Magnetic resonance imaging (MRI) has become one of the most important medical imaging techniques in the clinic due to its high degree of soft tissue resolution and no radiation damage, and it plays an important role in the early diagnosis and treatment of tumors. This article mainly studies the analysis of no-reflow in patients with acute ST-segment elevation myocardial infarction after PCI and the effect of coronary nicorandil on CoO nanoparticles combined with MRI. In this paper, the synthesized watersoluble nanoparticles are dispersed in a 2% xanthan gum or agarose solution. In an MRI analyzer, the T1 value is tested with the inversion recovery sequence, and the T2 value is tested with the hard pulse CPMG sequence. The gyroscope imaging sequence performs T1-weighted and T2-weighted imaging tests. Calculated densitometry (QCA) was used to measure the stenosis of the coronary lesions, the length of the lesions and the diameter of the lumen before stent implantation. In order to facilitate the collection of urine samples, this article adopts the method of inserting a catheter to drain the patient for sampling. From the baseline state at the time of enrollment to 150 minutes after PCI, polyethylene containing 0.1% butylated hydroxyanisole is used. Urine samples were taken from the test tube every 30 minutes, a total of 6 times were collected, and the collected urine samples were stored in a lowtemperature refrigerator at -80℃ for the final inspection. This paper uses calculation software to calculate the risk of death and death/myocardial infarction in the hospital and at 6 months after discharge. The data showed that the postoperatively detected CKMB and cTnI were higher than those before the operation, but the peak value of the nicorandil group was lower than that of the control group, but there was still no statistical difference (P>0.05). The results show that nicorandil can significantly improve the no-reflow phenomenon in AMI patients during PCI.

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Preparation of bio-nano bandage from quince seed mucilage/ZnO nanoparticles and its application for the treatment of burn

Cited by 20 publications

References 24 publications

Triamcinolone acetonide suppressed scar formation in mice and human hypertrophic scar fibroblasts in a dose-dependent manner

Triamcinolone acetonide suppressed scar formation in mice and human hypertrophic scar fibroblasts in a dose-dependent manner

Comparison of the Effects of 3D Printing Bioactive Porous Titanium Alloy Scaffolds and Nano-biology for Direct Treatment of Bone Defects

CoO Nanoparticles Combined with MRI: Analysis of No-Reflow in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI and the Effect of Coronary Nicorandil

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