Preparation of bioactive aerogel material based on sodium alginate and chitosan for controlled release of levomycetin

Abstract

This work was aimed at obtaining new highly porous two‐component alginate‐chitosan aerogels for use as a controlled‐release drug delivery system. Aerogel materials were prepared on the basis of the sodium alginate–chitosan interpolymer complex using sol–gel and supercritical fluid technologies. The effect of the ratio of sodium alginate and chitosan on the textural characteristics of aerogels and their water uptake capacity was studied. The obtained materials are characterized by a developed mesoporous structure and a specific surface area of up to 260 m2g−1. It was established that 1 g of alginate‐chitosan aerogel retains up to 35 g of water. The polyelectrolyte nature of the aerogel material, shape stability, high specific surface area, developed mesoporous structure, open cylindrical pore shape, and high water absorption make the alginate/chitosan aerogel material attractive for the purposes of sorption and application therapy. The aerogels can be used as drug delivery system demonstrating prolonged levomycetin release kinetics. The content of released levomycetin from the aerogel matrix within 4 h was up to 95%.

Tuning bio-aerogel properties for controlling drug delivery. Part 2: Cellulose-pectin composite aerogels

“…When the components are combined in a single entity where the individual components remain distinct and separate, the resultant composite material can exhibit different characteristics from the individual components and offer synergistic properties. Hybrid aerogels and their biomedical applications have been recently reported [21,22]. A number of organic-inorganic composite pectin aerogels have been reported, mostly with silica as the second component [23,24].…”

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

“…Gorshkova et al produced alginate–chitosan aerogel by combination of sol–gel and supercritical drying technologies. This aerogel demonstrated prolonged levomycetin release rates and has the potential to be employed in a drug delivery application [ 98 ]. Simonson et al investigated a gel-like aerogel in finding the weakness of Mycobacterium tuberculosis (MTB) and tuberculosis (TB)-infected cells to provide correlated pair of peptide and antibiotic for strong and quick antituberculosis treatment.…”

Optimizing cleanup of highly viscous oil spills: A biomass‐based aerogel with photothermal conversion and joule heating for a dual‐energy absorption device

“…Sodium alginate (SA) is a polysaccharide polymer extracted from brown algae, possessing advantages such as wide availability, low cost, non-toxicity and convenient ion cross-linking. 24 Research on SA-based aerogels has found extensive applications in various fields, including food, medicine and adsorption. However, SA aerogels suffer from drawbacks such as low mechanical strength and structural instability.…”

“…Among them, biomass‐based aerogels have gained increasing attention due to their environmental friendliness, non‐toxic nature and absence of secondary pollution. Sodium alginate (SA) is a polysaccharide polymer extracted from brown algae, possessing advantages such as wide availability, low cost, non‐toxicity and convenient ion cross‐linking 24 . Research on SA‐based aerogels has found extensive applications in various fields, including food, medicine and adsorption.…”