Preparation of Biodegradable Chitosan Semi-Interpenetrating Network Hydrogel and Its Application for Gastric Retention
Pei DONG,
Peng ZHANG,
Yang SHENG
et al.
Abstract:Gastric retention hydrogels represent a potential material with weight-loss effects and offer an effective solution to address the low bioavailability of drugs in pharmaceutical therapy. This study aims to develop a degradable hydrogel capable of prolonged retention in the stomach, facilitating both weight loss and drug release. Two degradable macromolecular crosslinking agents were synthesized, with acrylamide as the main monomer, mixed with chitosan solution for the preparation of a degradable hydrogel with … Show more
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