Preparation of biogenic silver chloride nanoparticles from microalgae Spirulina Platensis extract: anticancer properties in MDA-MB231 breast cancer cells

Afzali, Mahsa; Sadat Shandiz, Seyed Ataollah; Keshtmand, Zahra

doi:10.1007/s11033-023-08970-9

Cited by 2 publications

References 65 publications

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Structure‐Guided Identification of Novel Aromatase Inhibitors Targeting Breast Carcinoma

Yadav,

Tripathi,

Yadav

2024

Chemistry & Biodiversity

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Aromatase inhibitors play a critical therapeutic role in treating ER+ breast cancer, especially in postmenopausal women. However, their efficacy is often limited by resistance and severe side effects. Identifying new compounds that can disrupt aromatase enzyme function is essential. In this study, structural anomalies in the aromatase enzyme were corrected through energy minimization, and the structure was validated via Ramachandran plot. We screened 170,269 natural compounds from the ASINEX Biodesign library using high‐throughput screening algorithms to target the aromatase enzyme. Molecular docking identified three compounds: BDD30170158, BDE33872639, and BDE30177677, all showing stable binding interactions with the aromatase enzyme. Molecular dynamics simulations over 100 ns confirmed the conformational stability of these compounds. Although all three compounds exhibited the desired pharmacokinetic and drug metabolism properties, only one compound (BDE33872639) was identified as a non‐blocker, demonstrating a reduced risk of adverse cardiac effects. This compound exhibits significant potential as a novel aromatase inhibitor, warranting further experimental research to develop it as a therapeutic option for ER+ breast cancer.

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Structure‐Guided Identification of Novel Aromatase Inhibitors Targeting Breast Carcinoma

Yadav,

Tripathi,

Yadav

2024

Chemistry & Biodiversity

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Microbial Intervention With Nanomaterials

Athwal,

Garg,

Sudan

et al. 2024

Advances in Chemical and Materials Engineering

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Bioremediation, employing microorganisms to degrade or immobilize environmental contaminants, is a promising approach for mitigating agricultural pollution. Recent advancements have highlighted the potential of nanomaterials to enhance microbial remediation strategies in agroecosystems. This chapter synthesizes current knowledge on the synergistic application of nanomaterials and microbial intervention for bioremediation purposes in agricultural settings. We discuss the mechanisms underlying the enhanced bioremediation efficacy facilitated by nanomaterials, encompassing improved microbial activity, pollutant adsorption, and targeted delivery systems. Furthermore, we assess the environmental implications, challenges, and future prospects associated with this innovative approach. Understanding the interplay between nanomaterials and microbial communities is crucial for optimizing bioremediation strategies and fostering sustainable agricultural practices.

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Preparation of biogenic silver chloride nanoparticles from microalgae Spirulina Platensis extract: anticancer properties in MDA-MB231 breast cancer cells

Cited by 2 publications

References 65 publications

Structure‐Guided Identification of Novel Aromatase Inhibitors Targeting Breast Carcinoma

Structure‐Guided Identification of Novel Aromatase Inhibitors Targeting Breast Carcinoma

Microbial Intervention With Nanomaterials

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