Preparation of biomimetic nanofibers by electrospinning of blends of silk fibroin and chitosan for bone tissue engineering

Chen, Shih-Hsien; Lai, Guo-Jyun; Chen, Jyh‐Ping

doi:10.1109/inec.2011.5991742

Cited by 1 publication

(1 citation statement)

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“…Due to their large surface area and excellent porosity, the functionalized nanofibers were found to mimic the structure of the native tissue fibers of the extracellular matrix. Similarly, a solution of chitosan and silk fibroin was electrospun at 18 kV and a flow rate of 0.3 mL/h to produce nanofibers that were immersed in ethanol/ammonia solution resulting in the change in the conformation of the silk fibroin protein [28]. An accelerated proliferation rate and osteogenic differentiation of human fetal osteoblast progenitor (hFOB) cells were observed when they were cultured on the nanofibers.…”

Section: Biomimetic Polymeric Nanomaterialsmentioning

confidence: 99%

Perspectives on the Emerging Applications of Multifaceted Biomedical Polymeric Nanomaterials

Gumel

Annuar

Yusuf

2015

Journal of Nanomaterials

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Biodegradable and biocompatible polymeric nanomaterials, serving as biomedical devices have garnered significant attention as a promising solution to therapeutic management of many chronic diseases. Despite their potentials, majority of the synthetic nanomaterials used in biomedical applications lack crucial properties, for example, ligand binding sites, responsiveness, and switchability to efficiently deliver intended drugs to the target site. Advancements in manipulating nanoscale geometry have incurred the incorporation of triggered release mechanism within the nanomaterials design. This expanded their potential applications beyond nanocarriers to theranostics exhibiting both tandem drug delivery and diagnostic capabilities. Additionally, it highlights possibilities to design nanomaterials that could translate chemical response(s) to photometric display, thus making affordable biosensors and actuators readily available for biomedical exploitation. It is anticipated that, in the near future, these implementations could be made to access some of the most difficult therapy locations, for example, blood brain barrier to provide efficient management of Alzheimer, Huntington, and other neurodegenerative diseases. This review aims to serve as a reference platform by providing the readers with the overview of the recent advancements and cutting-edge techniques employed in the production and instrumentation of such nanomaterials.

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Section: Biomimetic Polymeric Nanomaterialsmentioning

confidence: 99%