Preparation of block copoly(ester-ether) comprising poly(l-lactide) and poly(oxypropylene) and degradation of its fibre in vitro and in vivo

Synthesis and characterization of poly(ethylene glycol) grafted poly(L-lactide)

“…The polymerization reaction catalyst Al(Et) 3 N 0.5 H 2 O was prepared as follows 10,12) : 20 mmol of triethylaluminium (in dry toluene, purchased from Aldrich) was transferred to a 20 ml vial. The solution was cooled in an external methanol bath ( -50 8C) followed by slowly adding a solution of 10 mmol of distilled water in 1,4-dioxane (1/9 v/v) with vigorous stirring.…”

“…One of the promising approaches to overcome these problems is to introduce hydrolyzable segments or branched units into PLLA 10,11) . Since poly(ethylene glycol) (PEG) is water-soluble and shows favorable biocompatibility, many researchers focused on the preparation of PLLA combined with PEG which enhances the hydrophilicity 12,13) . They showed that versatile properties could be obtained from block copolymers comprising polylactide and PEG, and proposed the possibility of its use as a tailor-made polymer for biomedical application.…”

Synthesis and characteristics of polydepsipeptide with pendant thiol groups

“…Biodegradable polylized. For example, lactide-glycolide copolymer, 3 mers that are hydrolyzed nonspecifically for a lactide-1-caprolactone copolymer, 4 and poly(LAgiven period or degraded selectively and/or rapgrafted-ethylene oxide) 5,6 have been previously idly under a specific condition can be used as biosynthesized as biocompatible and biodegradable materials in specific applications. We can assign medical polymers.…”

Synthesis and properties of multiblock copolymers consisting of poly(L-lactic acid) and poly(oxypropylene-co-oxyethylene) prepared by direct polycondensation

“…36,37 It was also found that the mechanical properties of the poly(␣-hydroxy acid)-based materials can be controlled by changes in the copolymer composition. 16 In a previous study, the authors prepared an A-B-A triblock copolymer which consisted of PLLA and polyether by the ring-opening polymerization of L-lactide and a telechelic polyether, poly(oxypropylene-co-oxyethylene) (PN; common trade name is Pluronic). 20,38 This copolymer could be melt-spun into a monofilament which was very flexible and had good mechanical properties.…”