Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application

Chen, Yanuo; Cheng, Hongye; Wang, Weina; Jin, Zhe; Liu, Qi; Yang, Huayun; Cao, Yong; Li, Weidong; Fakhri, Ali; Gupta, Vinod Kumar

doi:10.1016/j.jphotobiol.2021.112201

Cited by 49 publications

(13 citation statements)

References 55 publications

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“…These composites have found ample antibacterial applications (such as in water treatment [126][127][128][129] and the surface coating field [130][131][132]). In many cases, the CD-composites showed bactericidal activity upon sun light illumination [133][134][135][136]. It is worth noting that the use of metal-based composites for antibacterial applications may be counterbalanced by the inherent environmental and eukaryotic cellular toxicity of transition metals derivatives that should be taken into account to exclude off target effects [137][138][139][140].…”

Section: Cd-based Composite Materials For Antibacterial Applicationsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.

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Section: Cd-based Composite Materials For Antibacterial Applicationsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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“…There are different types of metal-containing CDs that can be used as antimicrobial agents: metal ion-doped CDs [ 36 , 60 , 61 , 62 ], metal nanoparticle-decorated CDs [ 41 , 60 , 63 , 64 , 65 ], CD/metal oxide nanocomposites [ 66 , 67 , 68 , 69 , 70 ], and CD/metal sulfide nanocomposites [ 71 ]. First, CDs doped with metal ions such as Cu 2+ [ 36 ] and Ag + [ 60 ] have been explored as antimicrobial materials.…”

Section: Antimicrobial Cdsmentioning

confidence: 99%

“…By inducing membrane disruption and intracellular DNA/protein damage, CD-2 displayed high and broad-spectrum antimicrobial activities against Gram-positive bacteria ( S. aureus ), Gram-negative bacteria ( E. coli , P. aeruginosa , and P. vulgaris ), and fungi ( S. cerevisiae ), with excellent biocompatibility. Third, CDs were integrated with metal oxide to form CD/metal oxide nanocomposites [ 66 , 67 , 68 , 69 , 70 ]. As an example, Gao et al fabricated CD/ZnO/ZnAl 2 O 4 nanocomposites which possessed an excellent antibacterial property with antibacterial ratios of 97% and 94% against S. aureus and E. coli , respectively [ 68 ].…”

Section: Antimicrobial Cdsmentioning

confidence: 99%

Carbon Dots for Killing Microorganisms: An Update since 2019

Lin

Wang

2022

Pharmaceuticals

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Frequent bacterial/fungal infections and occurrence of antibiotic resistance pose increasing threats to the public and thus require the development of new antibacterial/antifungal agents and strategies. Carbon dots (CDs) have been well demonstrated to be promising and potent antimicrobial nanomaterials and serve as potential alternatives to conventional antibiotics. In recent years, great efforts have been made by many researchers to develop new carbon dot-based antimicrobial agents to combat microbial infections. Here, as an update to our previous relevant review (C 2019, 5, 33), we summarize the recent achievements in the utilization of CDs for microbial inactivation. We review four kinds of antimicrobial CDs including nitrogen-doped CDs, metal-containing CDs, antibiotic-conjugated CDs, and photoresponsive CDs in terms of their starting materials, synthetic route, surface functionalization, antimicrobial ability, and the related antimicrobial mechanism if available. In addition, we summarize the emerging applications of CD-related antimicrobial materials in medical and industry fields. Finally, we discuss the existing challenges of antimicrobial CDs and the future research directions that are worth exploring. We believe that this review provides a comprehensive overview of the recent advances in antimicrobial CDs and may inspire the development of new CDs with desirable antimicrobial activities.

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“…Hydroxypropyl cellulose is a water-soluble cellulose ether, on the cellulose backbone the hydroxy group, and is propylated to produce hydroxypropyl cellulose [230]. On a commercial basis, it is prepared by reacting propylene oxide with alkali cellulose at a high pressure and temperature to get a substituted derivative of the cellulose ether.…”

Section: Hydroxypropyl Cellulosementioning

confidence: 99%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application

Cited by 49 publications

References 55 publications

Carbon Dots as an Emergent Class of Antimicrobial Agents

Carbon Dots as an Emergent Class of Antimicrobial Agents

Carbon Dots for Killing Microorganisms: An Update since 2019

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

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