Preparation of chitin-amphipathic anion/quaternary ammonium salt ecofriendly dressing and its effect on wound healing in mice

Zhou, Daijun; Yang, Rong; Yang, Tao; Xing, Malcolm; Luo, Gaoxing

doi:10.2147/ijn.s165005

Cited by 14 publications

(8 citation statements)

References 39 publications

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“…Most papers are dedicated to chitosan or ionically cross-linked chitin microspheres [52]. In one case, a chitin–amphipathic anion/quaternary ammonium salt dressing was prepared [53]. In our study, however, we utilized a recognized antibacterial compound—decamethoxine.…”

Section: Discussionmentioning

confidence: 99%

Naturally Drug-Loaded Chitin: Isolation and Applications

et al. 2019

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Naturally occurring three-dimensional (3D) biopolymer-based matrices that can be used in different biomedical applications are sustainable alternatives to various artificial 3D materials. For this purpose, chitin-based structures from marine sponges are very promising substitutes. Marine sponges from the order Verongiida (class Demospongiae) are typical examples of demosponges with well-developed chitinous skeletons. In particular, species belonging to the family Ianthellidae possess chitinous, flat, fan-like fibrous skeletons with a unique, microporous 3D architecture that makes them particularly interesting for applications. In this work, we focus our attention on the demosponge Ianthella flabelliformis (Linnaeus, 1759) for simultaneous extraction of both naturally occurring (“ready-to-use”) chitin scaffolds, and biologically active bromotyrosines which are recognized as potential antibiotic, antitumor, and marine antifouling substances. We show that selected bromotyrosines are located within pigmental cells which, however, are localized within chitinous skeletal fibers of I. flabelliformis. A two-step reaction provides two products: treatment with methanol extracts the bromotyrosine compounds bastadin 25 and araplysillin-I N20 sulfamate, and a subsequent treatment with acetic acid and sodium hydroxide exposes the 3D chitinous scaffold. This scaffold is a mesh-like structure, which retains its capillary network, and its use as a potential drug delivery biomaterial was examined for the first time. The results demonstrate that sponge-derived chitin scaffolds, impregnated with decamethoxine, effectively inhibit growth of the human pathogen Staphylococcus aureus in an agar diffusion assay.

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Section: Discussionmentioning

confidence: 99%

Naturally Drug-Loaded Chitin: Isolation and Applications

et al. 2019

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“…The results showed that this dressing had good antipollution and antibacterial activities which promoted wound healing. [ 71 ] Other typical cases of chitin used in antibacterial wound repair are presented in Table 1 .…”

Section: Applications Of Edible Materials In Skin Wound Healingmentioning

confidence: 99%

Edible Materials in Tissue Regeneration

Cheng

Gao

et al. 2021

Macromolecular Bioscience

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Edible materials have attracted increasing attention because of their excellent properties including availability, biocompatibility, biological activity, and biodegradability. Natural polysaccharides, phenolic compounds, and proteins are widely used in tissue regeneration. To better characterize their healing effect, this review article describes the applications of edible materials in tissue regeneration including wound healing and bone tissue regeneration. As an introduction to the topic, their sources and main bioactive properties are discussed. Then, the mechanism by which they facilitate wound healing based on their hemostasis, antibacterial, anti‐inflammatory, and antioxidant properties is systematically investigated. Moreover, a more comprehensive discussion is presented on the approaches by which edible materials can be used as scaffolds or agents for the provision of the components of natural bones for regulating the level of osteogenesis‐related cytokines to enhance bone repair. Finally, the prospects of edible materials for tissue regeneration are discussed.

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“…Furthermore, Pseudomonas aeruginosa -infected wounds in db/db diabetic mice were diminished by cleaning with cleansing agent hypochlorous acid and covering with silver nanoparticle/chitin in the form of nanofiber sheet [ 225 ]. Chitin-amphiphilic ion/quaternary ammonium salt having antibacterial and antipollution effects was also used for wound healing [ 226 ]. Chitin-lignin gels, as an extracellular matrix-like scaffold, were applied as wound dressing material that had a property of sustainable drug release especially antibiotics [ 227 ].…”

Section: Potential Applications Of Chitin and Chitosan Oligosacchamentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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Preparation of chitin-amphipathic anion/quaternary ammonium salt ecofriendly dressing and its effect on wound healing in mice

Cited by 14 publications

References 39 publications

Naturally Drug-Loaded Chitin: Isolation and Applications

Naturally Drug-Loaded Chitin: Isolation and Applications

Edible Materials in Tissue Regeneration

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

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