Preparation of Chitosan‐Coated Nanostructured Lipid Carriers (CH‐NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

Abstract

Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.

Comparative Study of Chitosan and Oligochitosan Coatings on Mucoadhesion of Curcumin Nanosuspensions

“…Some works in the literature have reported that chitosan coating on nano-carrier systems, such as nanostructured lipid carriers and nanoliposomes, could improve the encapsulation efficiencies in their systems [26,29]. coating on nano-carrier systems, such as nanostructured lipid carriers and nanoliposomes, could improve the encapsulation efficiencies in their systems [26,29]. Figure 2e shows the schematic representation of the Cur-NSs, CS-Cur-NSs, and OCS-Cur-NSs prepared in this study.…”

“…Positively charged CS and OCS could create a strong barrier surrounding Cur-NSs particles by electrostatic interactions with negatively charged lecithin molecules. Some works in the literature have reported that chitosan coating on nano-carrier systems, such as nanostructured lipid carriers and nanoliposomes, could improve the encapsulation efficiencies in their systems [26,29]. coating on nano-carrier systems, such as nanostructured lipid carriers and nanoliposomes, could improve the encapsulation efficiencies in their systems [26,29].…”

Biogenic engineered nanomaterials for enhancing bioavailability via developing nano-iron-fortified smart foods: advances, insight, and prospects of nanobionics in fortification of food

“…The enhanced encapsulation efficiency of CH-NLC was 83.9% more than that of the NLC of 73.6%, proving effective for iron fortification in milk and other beverages. 55…”

Recent Development in Essential Oil-Based Nanocarriers for Eco-Friendly and Sustainable Agri-Food Applications: A Review

“…Despite being better than SLNs, conventional NLCs still suffer from problems of leakage of encapsulant during storage and poor enzymatic stability. Polymeric coatings have been proven to enhance the chemical, enzymatic, and colloidal stability of NLCs. , Bashiri et al fabricated chitosan-coated NLC using a hot homogenization method for the encapsulation of cinnamon EO and evaluated its antioxidant potential for milk enrichment. Chitosan-coated NLCs exhibited enhanced stability and better resistance against aggregation.…”