Preparation of chitosan-containing nanofibres by electrospinning of chitosan/poly(ethylene oxide) blend solutions

Spasova, Mariya; Manolova, Nevena; Paneva, Dilyana; Rashkov, Iliya

doi:10.1515/epoly.2004.4.1.624

Cited by 104 publications

(103 citation statements)

References 19 publications

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“…The PET nanofibers have the potential to be used as blood vessels 15 while chitosan nanofibers can be used as an extracellular matrix (ECM) and in drug dosage forms. 16,17 One of the methods that introduce antibacterial activity to the PET textile can generate functional groups on to the surface of PETs by using gas plasma or formaldehyde treatment. This is subsequent to grafting antibacterial agents on to the activated surface of PETs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique

Jung

Huh

Meng

et al. 2007

J of Applied Polymer Sci

136

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ABSTRACT:The nanofiber deposition method, by electrospinning, was employed to introduce antibacterial activity and biocompatibility to the surface of poly (ethylene terephthalate) (PET) textiles. The polymer blends of PET and chitosan were electrospun on to the PET micro-nonwoven mats for biomedical applications. The PET/chitosan nanofibers were evenly deposited on to the surface, and the diameter of the nanofibers was in the range between 500 and 800 nm. The surface of the nanofibers was characterized using SEM, ESCA, AFM, and ATR-FTIR. The wettability of the PET nanofibers was significantly enhanced by the incorporation of chitosan. The antibacterial activity of the samples was evaluated utilizing the colony counting method against Staphylococcus aureus and Klebsiella pneumoniae. The results indicated that the PET/chitosan nanofiber mats showed a significantly higher growth inhibition rate compared with the PET nanofiber control. In addition, the fibroblast cells adhered better to the PET/chitosan nanofibers than to the PET nanofibers mats, suggesting better tissue compatibility.

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Section: Introductionmentioning

confidence: 99%

Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique

Jung

Huh

Meng

et al. 2007

J of Applied Polymer Sci

136

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“…The fabricated electrospun fibers were subjected for their antimicrobial activity, and results showed that blended nanofibers were found to be more effective against S. aureus and Klebsiella pneumoniae than pure PET matrices. In a similar study, Spasova et al [198] reported that electrospinning of chitosan/PEO blended solution was fabricated into nanofiber matrices and potassium 5-nitro-8-quinolinolate was incorporated into them to investigate the antimicrobial and antimycotic effect against gram-negative and gram-positive bacteria and fungi.…”

Section: Applications In Regenerative Medicinementioning

confidence: 99%

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Singh

Dutta

2015

Springer Series on Polymer and Composite Materials

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Intensive studies have been done to a wide range of natural and synthetic polymeric scaffolds which have been done for the use of implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure with compatible mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, differentiation, and guidance for cellular in growth at host tissue. One of the most abundantly available biopolymer chitins and its deacetylated derivatives is chitosan which is non-toxic and biodegradable. It has potential biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and biosensors. Recent literature shows the use of chitin and chitosan in electrospinning to produce scaffolds with improved cytocompatibility, which could mimic the native extra-cellular matrix (ECM). Similarly, silk from the Bombyx mori silkworm, a protein-based natural fiber, having superior machinability, biocompatibility, biodegradation, and bioresorbability, has evolved as an important candidate for biomedical porous material. This chapter focuses on recent advancements made in chitin, chitosan, and silk fibroin-based electrospun nanofibrous scaffolds, emphasizing on tissue engineering for regenerative medicine.

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“…The authors stated that the conductivity, surface tension, and moreover the solution viscosity is what allowed for electrospinning to occur when there was a mass ratio of PEO/chitosan of 2/1 or 1/1. Spasova et al 2004;Duan et al 2004;Desai et al, 2009, reported the electrospinning of chitosan/PEO system. It was observed that as the proportion of chitosan increased, the fiber diameter was decreased.…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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Preparation of chitosan-containing nanofibres by electrospinning of chitosan/poly(ethylene oxide) blend solutions

Cited by 104 publications

References 19 publications

Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique

Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

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