Preparation of chitosan–copper complexes and their antitumor activity

Zheng, Yong; Ying, Yibin; Qi, Yipeng; Wang, Yuting; Zhang, Weian; Du, Minquan

doi:10.1016/j.bmcl.2006.04.077

Cited by 59 publications

(31 citation statements)

References 12 publications

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“…Also chitosan/copper complexes have been found to possess high antitumor activity as they can interact with DNA leading to the chemically induced cleavage of DNA. The inhibition of 293 and HeLa cell proliferation by arresting of cell cycle progression at the S phase was observed [27,28]. Recently, a variety of new performing materials have been prepared by chemical or physical combination of chitosan with PEG, polyesters, gelatine, lipids, amphiphilic molecules, polysaccharides, or other natural or synthetic anionic polymers.…”

Section: Chitin and Chitosanmentioning

confidence: 99%

Polysaccharide-Based Anticancer Prodrugs

Caliceti

Salmaso

Bersani

2009

Macromolecular Anticancer Therapeutics

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So far, polysaccharides have been widely used in pharmaceutical technology as first choice excipients for production of traditional formulations. Nevertheless, in the recent years these natural and semisynthetic macromolecules have been addressed for new challenging applications as functional materials for innovative formulations. Their peculiar physicochemical and biological properties have been exploited to develop macromolecular prodrugs which can exhibit favorable biopharmaceutical properties and enforce the therapeutic performance of the parent drugs. These polymers display, in fact, high biocompatibility and biodegradability, multiple insertion points, and biological properties that can be advantageously exploited in drug delivery. In particular, the multifunctional structures of these polymers are anchoring points for conjugation of several anticancer drugs, which usually suffer from poor physicochemical, biopharmaceutical, and therapeutic properties that limit their therapeutic performance and proper use in anticancer treatment. Polysaccharide-based anticancer prodrugs can be designed to endow derivatives with new bioresponse, targeting, or environmental triggering properties or to combine molecules with synergistic therapeutic effect. Over the years, a variety of synthetic protocols have been set up to conjugate anticancer drugs to the polysaccharide backbone via specific linkages or through spacers which convey to the conjugates selective drug-delivery properties. Furthermore, the intrinsic antitumor activity and cell-targeting properties of few polysaccharides represent an additional value to the final therapeutic systems. Anticancer drugs with different pharmacodynamic, pharmacokinetic, and physicochemical properties have been successfully conjugated to various natural and semisynthetic polysaccharides highlighting the interesting perspectives for exploitation of new promising anticancer polymer therapeutics.

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Section: Chitin and Chitosanmentioning

confidence: 99%

Polysaccharide-Based Anticancer Prodrugs

Caliceti

Salmaso

Bersani

2009

Macromolecular Anticancer Therapeutics

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“…Chitosan Cu 2? complexes have also been reported for their antibacterial and antitumor properties (Zheng et al 2006). Results indicated that the inhibitory effects of chitosan-metal complexes can depend on the property of metal ions, the molecular weight and degree of deacetylation of the polymer and environmental pH values .…”

Section: Introductionmentioning

confidence: 96%

Study of chitosans interaction with Cu(II) from the corresponding sulfate and chloride salts

et al. 2015

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The interaction of copper ions with chitosan and three synthesized derivatives with different chelating centers, N-benzylidene chitosan, N-benzyl chitosan and poly-N-(4-(4-R-methoxyphenyl)diazenyl)-benzyl-chitosan using CuSO 4 Á5H 2 O and CuCl 2 Á2H 2 O salts was studied. The content of Cu 2? in the complexes was determined by atomic absorption spectrometry and the results showed that chitosan exhibited higher chelating capacity for both salts. Morphological changes of derivatives and complexes were demonstrated by SEM-EDS. In addition, the presence of some crystals attributed to copper sulfate adsorbed on the polymer surface was also observed, which indicates that part of the metal content is in the salt adsorbed and might influence in the use of the materials for further application studies. This result was supported by Raman spectroscopy results in which vibrations of O=S=O groups were observed. X-ray diffraction patterns showed that the chemical modification of chitosan and formation of complexes resulted in the decrease of crystallinity. Electron paramagnetic resonance was used to investigate structural aspects of the materials complexed with Cu 2? ions in the solid state.

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“…chitosan-metal complexes are far superior to chitosan and metal salts for studies related to in vitro antimicrobial activities [8]. Chitosan-copper complexes are known to have antitumour activities, especially at a ratio of 0.11 mol copper per one chitosan residue [9].…”

Section: Introductionmentioning

confidence: 99%