Preparation of chitosan nanoparticles by spray drying, and their antibacterial activity

Investigations of the Influences of Processing Conditions on the Properties of Spray Dried Chitosan-Tripolyphosphate Particles loaded with Theophylline

“…The active ingredient was entrapped in a biopolymer carrier under a hot drying medium. Various applications of spray-dried chitosan microspheres in drug delivery have been published [8][9][10][11] .…”

“…However, chitosan is a polysaccharide material with high viscosity which makes difficulties in the optimized control over the initial formulation (precursor solution) and operation conditions of a spray dryer 11 , which may provide a broad distribution of particle size leading to a reduced delivery effectiveness of the drugs encapsulated and causing a crucial problem in drug delivery design for pharmaceutical applications 12,13 . For example, particle sizes of spray-dried chitosan particles had been reported to be determined not only by the spray drying process parameters but also by the precursor concentration of feed solutions 7 .…”

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

“…Conversely, low surface tension, high atomization pressure and small nozzle diameter render smaller particles. Regarding the particles morphology, faster solvent evaporation rate (lower point boiling) usually leads to particles that are more porous due to shorter time for the droplets shrinkage [21,[27][28][29]. Finally, the air outlet temperature is dependent on other process variables [9,24].…”

Chitosan Based Self-assembled Nanoparticles in Drug Delivery

“…Different approaches have been used to produce CS nanoparticles. These include ionotropic gelation [13,14], spray drying [15], water-in-oil emulsion cross-linking [16], reverse micelle formation [17,18], emulsion-droplet coalescence [19,20], nanoprecipitation [21] and by a self-assembling mechanism [22,23].…”