Preparation of Ciprofloxacin-Based Carbon Dots with High Antibacterial Activity

Abstract

Nowadays, bacterial infections are attracting great attention for the research and development of new antimicrobial agents. As one of the quinolones, ciprofloxacin (CI) has a broad-spectrum, strong antibacterial effect. However, the clinical use of ciprofloxacin is limited by drug resistance. Ciprofloxacin carbon dots (CCDs) with enhanced antibacterial activity and copper-doped ciprofloxacin carbon dots (Cu-CCDs) were synthesized by a simple hydrothermal method. The results of structural analysis and antibacterial experiments show that CCDs and Cu-CCDs have effective antibacterial properties by retaining the active groups of ciprofloxacin (-COOH, C-N, and C-F), and Cu-CCDs doped with copper have a better antibacterial effect. In addition, experiments have shown that Cu-CCDs show excellent antibacterial activity against E. coli and S. aureus and have good biocompatibility, which indicates that they have great prospects in clinical applications. Therefore, novel modified copper CCDs with broad-spectrum antibacterial activity, which can be used as antibacterial nanomaterials for potential applications in the field of antibacterial drugs, were synthesized in this study.

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

“…Thus, in this work, unique modified copper C-CNDs with broad-spectrum antibacterial activity were produced. These C-CNDs may be employed as antibacterial nanomaterials for future uses in the development of antibacterial medications . Folic acid was the starting material utilized by Eman Serag et al to hydrothermally manufacture carbon dots.…”

“…These C-CNDs may be employed as antibacterial nanomaterials for future uses in the development of antibacterial medications. 162 Folic acid was the starting material utilized by Eman Serag et al to hydrothermally manufacture carbon dots. Curcumin was then loaded onto the carbon dots to create a folic acid carbon dot/Curcumin nanocomposite.…”

“…The features of ROS formation of h/CNDs@CPT NVs during laser irradiation and the intracellular ROS-triggered CPT release phenomena for PDT and treatment of cancer are shown in the right-side diagram. Reproduced with permission from ref . Copyright 2023 MDPI AG (Multidisciplinary Digital Publishing Institute).…”

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

“…It has been reported to be many times more effective than norfloxacin and enoxacin. CIP also exhibits good antibacterial action and pharmacokinetic qualities with little adverse effects [ 15 , 16 ]. Traditional Chinese herbs are unique medicinal substances used in traditional Chinese medicine and serve as a significant hallmark distinguishing it from other medical practices.…”

Carbonized Tetracycline: a new class of nanomaterial with tuneable antioxidant, reduced cytotoxicity, immunomodulatory, and osteogenic properties

“…3 Notably, it was reported that a few properties of the starting raw materials could be retained after carbonization also. 3,5 For example, the carbonized form of a few small drug molecules, such as aspirin 6 levofloxacin, 7 2-methoxy-1, 4-naphthoquinone, 8 and ciprofloxacin, 9 are shown to have better therapeutic properties. Although the mechanisms for the enhanced therapeutic properties are not fully clear, the change in water dispersibility, systemic circulation half-life, cellular uptake, and retention of the carbonized materials are thought to play a crucial role.…”