Preparation of co-electrospinning membrane loaded with simvastatin and substance P to accelerate bone regeneration by promoting cell homing, angiogenesis and osteogenesis

Al-Baadani, Mohammed A.; Xu, Lihua; Cai, Kexin; Yie, Kendrick Hii Ru; Shen, Yiding; Al-Bishari, Abdullrahman M.; Al-Shaaobi, Bilal A.; Ma, Pingping; Shen, Xinkun; Liu, Jinsong

doi:10.1016/j.mtbio.2023.100692

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…205 Moreover, a hierarchical polycaprolactone/gelatin (PCL/Gel) co-electrospinning membrane was designed and fabricated to initiate a burst release of SP and a slow/sustained release of simvastatin (SIM) for neurovascularization of bone healing. 206 In addition, SP and lactoferrin (LF) in a Chi-PLGA-calcium sulfate (CS) hydrogel increased cell proliferation and migration during calvarial injury repair. 207 In addition to SP, researchers have explored the utilization of other neurotransmitters.…”

Section: Drug Delivery Systems With Neurotransmittersmentioning

confidence: 99%

Emerging roles of nerve‐bone axis in modulating skeletal system

Li,

Zhang,

Tang

et al. 2024

Medicinal Research Reviews

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Over the past decades, emerging evidence in the literature has demonstrated that the innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The nerve‐bone axis sparked extensive preclinical and clinical investigations aimed at elucidating the contribution of nerve‐bone crosstalks to skeleton metabolism, homeostasis, and injury repair through the perspective of skeletal neurobiology. To date, peripheral nerves have been widely reported to mediate bone growth and development and fracture healing via the secretion of neurotransmitters, neuropeptides, axon guidance factors, and neurotrophins. Relevant studies have further identified several critical neural pathways that stimulate profound alterations in bone cell biology, revealing a complex interplay between the skeleton and nerve systems. In addition, inspired by nerve‐bone crosstalk, novel drug delivery systems and bioactive materials have been developed to emulate and facilitate the process of natural bone repair through neuromodulation, eventually boosting osteogenesis for ideal skeletal tissue regeneration. Overall, this work aims to review the novel research findings that contribute to deepening the current understanding of the nerve‐bone axis, bringing forth some schemas that can be translated into the clinical scenario to highlight the critical roles of neuromodulation in the skeletal system.

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Section: Drug Delivery Systems With Neurotransmittersmentioning

confidence: 99%

Emerging roles of nerve‐bone axis in modulating skeletal system

Li,

Zhang,

Tang

et al. 2024

Medicinal Research Reviews

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“…It is speculated that the simvastatin-induced increases in BMP-2 and BMP-7 mediated meniscus regeneration. In addition, simvastatin promotes the migration and homing of MSCs [171], providing another potential mechanism for enhancing meniscus tissue regeneration [52].…”

Section: Wingless-type Mmtv Integration Site Family Member 5a (Wnt5a)mentioning

confidence: 99%

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

Zhou,

Wang,

Jiang

et al. 2024

Gels

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Meniscus tissue engineering has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities.

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Growth factor collected cell membrane-functionalized matrix for vascular-innervated bone regeneration

Qiao,

Zou,

2025

Composites Part B: Engineering

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Preparation of co-electrospinning membrane loaded with simvastatin and substance P to accelerate bone regeneration by promoting cell homing, angiogenesis and osteogenesis

Cited by 5 publications

References 46 publications

Emerging roles of nerve‐bone axis in modulating skeletal system

Emerging roles of nerve‐bone axis in modulating skeletal system

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

Growth factor collected cell membrane-functionalized matrix for vascular-innervated bone regeneration

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