Preparation of Coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique

Chen, Siyuan; Liu, Wei; Wan, Jing; Cheng, Xu; Gu, Conghui; Zhou, Hui; Chen, Shan; Zhao, Xiaojing; Tang, Yu-Wen; Yang, Xiangliang

doi:10.3109/03639045.2011.650648

Cited by 70 publications

(32 citation statements)

References 36 publications

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“…Blank formulations (free from Co‐Q10) were also prepared using the same procedure without any Co‐Q10 in the lipid phase. In order to prepare NLC‐based gel, Carbopol 940 was completely dispersed in the NLC and NLC/Co‐Q10 dispersion under constant stirring according to the previously reported method . Thereafter, triethylamine was added dropwise to adjust the pH at the value of 7.0 in order to promote gelation .…”

Section: Methodsmentioning

confidence: 99%

“…Co‐Q10 is a highly lipophilic, and thermolability substance with low topical bioavailability . In addition, Co‐Q10 is chemically unstable and easy to degrade as exposed to light, which limits its pharmaceutical effect. Nowadays, the pharmaceutical skin products containing Co‐Q10 are mostly ordinary emulsions or gels, which do not show prolonged release.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Co‐Q10 is chemically unstable and easy to degrade as exposed to light, which limits its pharmaceutical effect. Nowadays, the pharmaceutical skin products containing Co‐Q10 are mostly ordinary emulsions or gels, which do not show prolonged release. However, Co‐Q10 may be effective as adjunctive treatment for inflammation either as a stand‐alone biological or in combination with other antioxidants.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Anti-Inflammatory Potential of Different Formulations Based on Coenzyme Q10-Loaded Nanostructured Lipid Carrier: In Vitro, Ex Vivo, and In Vivo Evaluations

Ahmadi¹,

Rostamizadeh

Modarresi‐Alam³

2018

Eur. J. Lipid Sci. Technol.

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An attempt is made to study skin anti‐inflammatory activity for different formulations of Co‐Q10 loaded nanostructured lipid carriers (NLC) including NLC, NLC‐based gel, and W/O cream. NLCs are prepared by a hot high speed homogenization method using cetylpalmitate as solid lipid, coconut oil as liquid lipid, and tween 80 as surfactant. NLCs are characterized by different techniques including dynamic light scattering, transmission electron microscopy, and FT‐IR. Stable formulation with a mean size range of 118.7 ± 6.9 nm and zeta potential of −29.1 ± 1.96 mV is developed. Drug loading content for NLC/Co‐Q10, NLC‐based gel, and W/O cream formulations is 7.945 ± 0.035%, 4.79 ± 0.052%, and 2.39 ±0.041%, respectively. All formulations show high entrapment efficiency (EE) (>96% w/w). The formulations are prepared and characterized in terms of rheology, pH, anti‐radical activity, ex vivo skin permeation, and in vivo anti‐inflammatory activity. A drug release study exhibits that the maximum attainable drug release after 48 h for NLC/Co‐Q10 is 11.94% versus 14.4% for NLC‐based gel and 41.56% for W/O cream. Ex vivo studies on rat skin reveals that Co‐Q10 contained in the W/O cream formulation penetrates into the stratum corneum more readily than that in the NLC/Co‐Q10 and NLC‐based gel formulations. In vivo studies of acute anti‐inflammatory activity of NLC‐based formulations show significant difference between inhibition effect of W/O cream and NLC/Co‐Q10 compared to betamethasone. Practical Applications: The findings indicate that formulation based on NLC/Co‐Q10 is suitable not only in skin penetration but also in dermatology. Anti‐inflammatory activity for different formulations of Co‐Q10 loaded NLC including NLC, NLC‐based gel, and W/O cream is investigated. All formulations show suitable physicochemical properties and high drug loading capacity for being used as dermatological formulations. The order of drug release after 48 h is NLC/Co‐Q10 < NLC‐based gel < W/O cream. In ex vivo study, the fastest penetration rate into the stratum corneum is obtained for W/O cream. W/O cream and NLC/Co‐Q10 formulations show significant acute anti‐inflammatory activity compared to betamethasone in in vivo study.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic Anti-Inflammatory Potential of Different Formulations Based on Coenzyme Q10-Loaded Nanostructured Lipid Carrier: In Vitro, Ex Vivo, and In Vivo Evaluations

Ahmadi¹,

Rostamizadeh

Modarresi‐Alam³

2018

Eur. J. Lipid Sci. Technol.

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“…The improved skin uptake of GLT might result from the general adhesiveness to skin surfaces of nanoparticles (Müller & Jacobs, 2002), which leads to a prolonged residence and contact time in the skin, thereby increasing its skin deposition. For the development and optimization of pharmaceutical dermal products and cosmetics, a certain penetration into the skin is desired, especially if the active compound should be localized in the skin but not systemically absorbed (Mitri et al, 2011;Chen et al, 2013).…”

Section: In Vitro Permeation Study and Skin Deposition Studiesmentioning

confidence: 99%

Nanogel for dermal application of the triterpenoids isolated fromGanoderma lucidum(GLT) for frostbite treatment

Shen

et al. 2014

Drug Delivery

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“…Zhao et al [3] prepared the injection of fat emulsion by combining the piston-slit homogenization method with the high-pressure micro-jet, and studied the factors influencing the particle size and particle size distribution. Barnadas-Rodriguez et al [4] prepared phospholipid liposomes, Saheki et al [5] prepared egg yolk and soybean oil mixed lipid nano-dispersion, Chen et al [6] prepared coenzyme Q10 nano lipid carrier, respectively, the use of high pressure micro jet Technology under different pressures and different processing times to get a different micro-nano particle size and particle size distribution. LI Guangji [7] used the micro-jet technology combined with the ultra-high pressure technology and the impinging stream technology, proposed a new method of emulsification to overcome the complexity of the traditional mechanical method, low energy utilization, insufficient shear force, difficult control of the working process and other shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Experimental Study on the Effect of High Pressure Micro-jet Parameters on Homogeneity Performance

Dong¹

2017

dtetr

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Abstract. High-pressure micro-jet homogenization technology is one of the commonly used methods in the preparation of liquid chemicals. The study on the influence of the parameters of high pressure micro jet on the homogeneity of the agential is helpful to improve the efficacy and safety of the agential. In this paper, using high pressure homogenizer as experimental platform, the oil-water emulsion as homogeneous material, the variation law of homogeneous particle size under the conditions of homogeneous pressure, initial temperature and oil / water ratio was studied. The experimental results show that the particle size of oil droplets decreases with the increase of homogenization pressure; the particle size of oil droplets increases with the increase of initial temperature; and the particle size of oil droplets decreases with the decrease of oil/water ratio. The experimental basis is provided to improve the homogeneity of high pressure micro jet homogenizer.

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Preparation of Coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique

Abstract: Q10-NLC exhibited a significant epidermal targeting effect, which was proved to be a promising carrier for topical delivery of Q10.

Cited by 70 publications

References 36 publications

Therapeutic Anti-Inflammatory Potential of Different Formulations Based on Coenzyme Q10-Loaded Nanostructured Lipid Carrier: In Vitro, Ex Vivo, and In Vivo Evaluations

Therapeutic Anti-Inflammatory Potential of Different Formulations Based on Coenzyme Q10-Loaded Nanostructured Lipid Carrier: In Vitro, Ex Vivo, and In Vivo Evaluations

Nanogel for dermal application of the triterpenoids isolated fromGanoderma lucidum(GLT) for frostbite treatment

Experimental Study on the Effect of High Pressure Micro-jet Parameters on Homogeneity Performance

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