2009
DOI: 10.1002/9780470743447
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Preparation of Compounds Labeled with Tritium and Carbon‐14

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Cited by 165 publications
(200 citation statements)
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“…Synthesis of bis(4-chlorophenyl)-, bis(4-bromophenyl)imidazolidine-2,4-dione were reported 10 having several derivatives located at the N-1 and N-3 position and all of them were in a very low yield. The only iodinated 5,5'-diphenylhydantoin (phenytoin) was reported and marketed as mephenytoin 11 , the parent molecules was phenytoin which iodinated with N-iodosuccinimide (NIS) in triflourosulphonic acid in only 17 % yield. Direct iodination of diphenylhydantoin with iodine monochloride ICl was tried in dichloromethane with the existence of hydrogen chloride captured reagent zinc oxide (ZnO), effectively took place to give 70 % yield 5,5-bis(4'-iodophenyl)imidazolidine-2,4-dione.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Synthesis of bis(4-chlorophenyl)-, bis(4-bromophenyl)imidazolidine-2,4-dione were reported 10 having several derivatives located at the N-1 and N-3 position and all of them were in a very low yield. The only iodinated 5,5'-diphenylhydantoin (phenytoin) was reported and marketed as mephenytoin 11 , the parent molecules was phenytoin which iodinated with N-iodosuccinimide (NIS) in triflourosulphonic acid in only 17 % yield. Direct iodination of diphenylhydantoin with iodine monochloride ICl was tried in dichloromethane with the existence of hydrogen chloride captured reagent zinc oxide (ZnO), effectively took place to give 70 % yield 5,5-bis(4'-iodophenyl)imidazolidine-2,4-dione.…”
Section: Resultsmentioning
confidence: 99%
“…Method B: by applying the standard procedure 11 for the preparation of phenytoin to give compound 3 in 60 % yields.…”
Section: 5-bis(4'-iodophenyl)imidazolidine-24-dione (3)mentioning
confidence: 99%
“…A number of geochemical indicators for petroleum exploration involve ratios of methylphenanthrene concentrations [13]. Studies have been made of the behaviour of these compounds using labelling techniques, eg by the 14 C method [14,15], and other analytical and labelling methods [14,16,17]. The advantage of using 13 C is that it is not a radioactive tracer so does not carry the same environmental risks on release to the atmosphere.…”
Section: Introductionmentioning
confidence: 99%
“…The demethylation reaction can be followed by use of 14 C labelled substrates, but the attendant health and safety issues led us to explore the possibility of 13 C labelling with product analysis by gas chromatography-mass spectrometry (GC-MS). undertaken using 13 C labelling and these are summarised in a recent publication [24].…”
Section: Introductionmentioning
confidence: 99%
“…3,[14][15][16]18 In Figures 4B and 5, the reduction of a carboxylic acid with LiAlT 4 and the reduction of an ester with LiBEt 3 T are shown. Reactions were performed in typical scales of 40 mmol of the tritide reagent, corresponding to an activity of 4.0 Ci.…”
mentioning
confidence: 99%