Preparation of Conjugated Polymer Grafted with H<sub>2</sub>O<sub>2</sub>-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing

Li, Meng; Li, Shengliang; Chen, Hui; Hu, Rong; Liu, Libing; Lv, Fengting; Wang, Shu

doi:10.1021/acsami.5b11846

Cited by 50 publications

(27 citation statements)

References 32 publications

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“…16,17 It is well recognized that ROS is usually elevated in various tumors, 18,19 and numerous stimuliresponsive delivery systems containing ROS-responsive groups, such as aryl boronic ester, ferrocenyl, selenium, and thioether groups, have been constructed for excellent controlled-release of drugs. 20 For instance, Li et al 21 have conjugated a nitrogen mustard onto a polymer via a cyclic boronate ester group and the polymeric nanoparticles have shown H 2 O 2 -induced DNA alkylation as well as enhancement of cell inhibition efficiency in A549 cells.…”

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confidence: 99%

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luo¹,

Liu²,

Cui³

et al. 2017

IJN

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Background The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. Materials and methods We synthesized a highly biocompatible 4-(hydroxymethyl) phenylboronic acid (HPBA)-modified poly(ethylene glycol) (PEG)-grafted poly(acrylic acid) polymer (PPH) and fabricated a Cur-coordinated ROS-responsive nanoparticle (denoted by PPHC) based on the interaction between boronic acid and Cur. The mean diameter of the Cur-coordinated PPHC nanoparticle was 163.8 nm and its zeta potential was −0.31 mV. The Cur-coordinated PPHC nanoparticle improved Cur stability in physiological environment and could timely release Cur in response to hydrogen peroxide (H 2 O 2 ). PPHC nanoparticles demonstrated potent antiproliferative effect in vitro in A549 cancer cells. Furthermore, the viability of cells treated with PPHC nanoparticles was significantly increased in the presence of N -acetyl-cysteine (NAC), which blocks Cur release through ROS inhibition. Simultaneously, the ROS level measured in A549 cells after incubation with PPHC nanoparticles exhibited an obvious downregulation, which further proved that ROS depression indeed influenced the therapeutic effect of Cur in PPHC nanoparticles. Moreover, pretreatment with phosphate-buffered saline (PBS) significantly impaired the cytotoxic effect of Cur in A549 cells in vitro while causing less damage to the activity of Cur in PPHC nanoparticle. Conclusion The Cur-coordinated nanoparticles developed in this study improved Cur stability, which could further release Cur in a ROS-dependent manner in cancer cells.

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confidence: 99%

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luo¹,

Liu²,

Cui³

et al. 2017

IJN

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“…Furthermore, the luminescing and O 2 ‐supplying system could be used for the controlled release of anticancer prodrug, offering the possibility of simultaneous PDT and chemotherapy. We synthesized a prodrug with an ROS‐responsive moiety, and a possible release mechanism is proposed in Figure a. The prodrug was first oxidized at the C–B bond by ROS, followed by deboronation and chlormethine release.…”

Section: Figurementioning

confidence: 99%

Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

et al. 2019

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Photodynamic therapy( PDT) is ap romising method for cancer treatment. Tw op arameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared as ystem for PDT using hemoglobin (Hb)-linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzesthe activation of luminol, the conjugated polymer poly[2-methoxy-5-(2ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells.T his system could be used for the controlled release of an anticancer prodrug.The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides ap roof-of-concept to explore smart and multifunctional nanoplatforms for phototherapy.

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“…Because anticancer drugs are covalently conjugated onto polymer backbones with responsive bonds, the polymer–drug conjugates can remain stable in the blood circulation for a long time. However, cargoes, including chemical drugs, therapeutic gases, targeting peptides, and other small functional molecules, can be instantly liberated from the nanosystem if the conjugates are exposed to endo‐/exogenous stimuli in the tumor sites …”

Section: Introductionmentioning

confidence: 99%

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

Qin

2020

ChemBioChem

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The emergence and development of nanomedicine have alleviated problems existing in traditional chemotherapy drugs, such as short lifetime, concomitant side effects, and weak tumor‐targeting capability. Nevertheless, the further applications of drug‐loaded nanocarriers are still limited by their premature leakage, weak targeting capability, and insufficient intracellular release. In past decades, various nanocarriers, including gold nanoparticles, porous silica nanoparticles, carbon‐based nanoparticles, micelles, liposomes, and polymer–drug conjugates, have been intensively investigated for tumor therapy. Among these, polymer‐based nanocarriers have attracted more attention due to their biocompatibilities and capability of being modified for stimuli‐responsive drug release. In this review, three popular strategies to design and synthesize polymer‐based stimuli‐responsive nanocarriers are discussed. The discussion goes from stimuli‐responsive polymers with responsive backbones or modified by responsive functional groups for drug encapsulation and release to polymer–drug conjugates with responsive covalent linkages. In particular, due to the facile synthetic processes and mild reaction conditions for crosslinked structures, the latest progress in responsive crosslinked structures is emphasized. Finally, future perspectives for these nanomaterials are given, which are expected to provide inspiration for researchers to design more effective and safer tumor‐killing nanomedicines.

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Preparation of Conjugated Polymer Grafted with H₂O₂-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing

Cited by 50 publications

References 32 publications

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

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Preparation of Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing

Cited by 50 publications

References 32 publications

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

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Preparation of Conjugated Polymer Grafted with H₂O₂-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing