Preparation of Controlled-Release Microspheres of Ibuprofen With Acrylic Polymers by a Novel Quasi-Emulsion Solvent Diffusion Method

Kawashima, Yasunaru; Niwa, Toshiyuki; Handa, Tetsurou; Takeuchi, Hirofumi; Iwamoto, Taro; Itoh, K.

doi:10.1002/jps.2600780118

Cited by 168 publications

(78 citation statements)

References 14 publications

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“…4). The drug release from formulation RSPO 1:1.5 was less compared to RLPO 1:1.5, because Eudragit RLPO tends to swell more than Eudragit RSPO in aqueous medium (26,27). Also, Eudragit RLPO is more permeable to aqueous medium than Eudragit RSPO (28).…”

Section: Resultsmentioning

confidence: 98%

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Patra¹,

Kumar²,

Pandit³

et al. 2007

Acta Pharmaceutica

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Section: Resultsmentioning

confidence: 98%

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Patra¹,

Kumar²,

Pandit³

et al. 2007

Acta Pharmaceutica

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“…The floating gastroretentive systems (FGS) are used to achieve gastric retention of orally administered solid dosage forms (7). The effectiveness and application of these systems have been evaluated in vitro and in vivo, and widely discussed (1,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Kawashima et al (9) have proposed a system of hollow microspheres (microballoons) to increase the containment time of tranilast and ibuprofen in the stomach.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

et al. 2011

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Abstract. The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporation. The proposed system was evaluated in vitro for particle morphology, lag time and floating time, loading rate, release profile, and the release kinetic of AZT release. AZT's physicochemical characteristics were evaluated by differential scanning calorimetry (DSC), X-ray diffraction (XDR) and infrared spectroscopy (IR). The particles obtained were sphere-shaped, hollow, and had porous walls. The floating was immediate, and floating time was higher than 12 h. The loading rate was 34.0±9.0%. The system obtained had an extended release. DSC and XDR results showed a modification in AZT's solid state. IR spectroscopy revealed that the chemical structure of the AZT was unchanged. The hollow microballoons presented gastroretentive, floating, and extended-release properties.

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“…For example, as early as1989, Kawashima 17 had prepared the ibuprofen microsponges by using quasi-emulsion solvent diffusion method, and since then, this kind of method for preparation of microsponge was commonly used. [18][19][20][21] And subsequently, the advantages of microsponges were found and revealed by researches gradually.…”

Section: Initial Discoveriesmentioning

confidence: 99%

Toward Application of Microsponges in Transdermal Drug Delivery System

Hong¹,

Chen²,

Xiang³

et al. 2015

MOJBB

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Abbreviations: TDDS, transdermal drug delivery system; FDA, food and drug administration; EC, ethyl cellulose; BPO, benzoyl peroxide; SEM, scanning electron microscopy; AUC, area under the curve; EE, entrapment efficiency; DSC, differential scanning calorimetry; MED, minimal erythemal dose; SPF, sun protection factor IntroductionCompared with drug dosage forms for oral and parenteral administration, Transdermal drug delivery system (TDDS) can minimize and avoid some restrictions relating to dosage forms effectively. Due to the conventional delivery systems suffering from certain restrictions like Peak and Valley phenomenon i.e., they show fluctuations in plasma drug concentration and cannot render sustained effect.1 However, the TDDS can meet the requirement to keep relatively stable plasma drug concentration and prolong delivery of drug, in a steady-state profile and minimizes the peak-associated side effects, which thus ensures the level of the drug is effective for treatment on the minimal therapeutic concentration. In general, Transdermal drug delivery system, as a controlled drug delivery system, is exceedingly humanized, commodious and prolong the period of time of release of drug, if need arises (e.g. systemic toxicity) with less pain sensation while administrating drug candidates. Additionally, TDDS permits the permeation of drugs across the skin and into the systemic circulation which avoids the hepatic first-pass effect observed in the course of oral administration and inconvenience of frequent parenteral administration. As a new drug carrier of TDDS, Microsponges are mostly used for topical 4-10 and oral administration. 11-15 For other topical delivery systems, the traditional delivery systems are required of frequent dosing to keep relatively stable local concentrations of effective constituent for therapeutic effectiveness because of low effectiveness.Thus to avoid this defect it is indispensable to design a new drug delivery system to prolong the residual time of drug in the epidermis or the dermis, while reduce its penetration into the body. For this reason, as a porous polymeric microsphere, Microsponges can fulfill such aims uniquely.4 Microsponges are porous, polymeric microspheres (Figure 1) which are invariably used for topical delivery system; 4-5,7-10 its inside are full of lacunas and its particle size is 5~300μm in diameter. AbstractTransdermal drug delivery system (TDDS) is a dosage form designed to deliver drug through skin by topical route of administration to the systemic circulation or for local treatment. As a new type of dosage form, TDDS has a number of special merits, but inevitably at the same time it possess some distinct disadvantages, such as low permeability and the drug mostly enter the systemic vascular. Microsponges are a kind of micro-sized and polyporous particles which can entrap effective constituents, and are biologically safe. And Microsponges also exhibit distinctive advantage at the aspect of drug release. The TDDS can enhance drug stability, decrease side effec...

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Preparation of Controlled-Release Microspheres of Ibuprofen With Acrylic Polymers by a Novel Quasi-Emulsion Solvent Diffusion Method

Cited by 168 publications

References 14 publications

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

Toward Application of Microsponges in Transdermal Drug Delivery System

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