Preparation of crosslinked starch microspheres and their drug loading and releasing properties

Fang, Yuanyuan; Wang, Lijun; Li, Dong; Li, Bing-zheng; Bhandari, Bhesh; Chen, Xiao; Mao, Zhihuai

doi:10.1016/j.carbpol.2008.03.005

Cited by 95 publications

(45 citation statements)

References 19 publications

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“…The SF/chitosan blended microparticles have been prepared by the coacervation/cross-linking method [14]. Starch is a non-toxic, biodegradable, biocompatible, edible and relative inexpensive material that has been widely studied in the entrapment of food ingredients [15,16] and drugs [17][18][19]. Almost all starch microparticles have been prepared by an emulsification-cross-linking reaction [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Morphology and thermal stability of silk fibroin/starch blended microparticles

Baimark¹,

Srisa-ard²,

Srihanam³

2010

Express Polym. Lett.

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Abstract. In the present study biodegradable microparticles of silk fibroin (SF)/starch blends were prepared by a simple water-in-oil emulsion solvent diffusion technique. SF/starch blended solution and ethyl acetate were used as water and oil phases, respectively. The influence of SF/starch ratios on characteristics of the blended microparticles was investigated. The SF conformation of microparticle matrices from FTIR analysis was changed from random coil to β-sheet form by blending with starch. The blended microparticles had lower dissolution in water than those of SF and starch microparticles. The 1/3 (w/w) SF/starch blended microparticles exhibited the lowest dissolution. The SF and starch microparticles showed irregular and deflated shapes, respectively. The blended microparticles were nearly spherical in shapes and smaller sizes. Thermal stability of the blended microparticles slightly increased with the starch blended ratio. The results suggested that SF conformational transition, thermal stability, morphology and dissolution of the blended microparticles can be adjusted by varying the blended ratio.

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Section: Introductionmentioning

confidence: 99%

Morphology and thermal stability of silk fibroin/starch blended microparticles

Baimark¹,

Srisa-ard²,

Srihanam³

2010

Express Polym. Lett.

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“…The preparation of starch microparticles for drug delivery applications has been the subject of many publications, especially in the last decade [60][61][62]. Generally, the methods used to prepare starch microparticles include a cross-linking step, during or after particle formation [60,61,63].…”

Section: Starchmentioning

confidence: 99%

“…Generally, the methods used to prepare starch microparticles include a cross-linking step, during or after particle formation [60,61,63]. Since starch is a hydrophilic polymer, the crosslinking of the polyssacharide chains is required to obtain microparticles that are resistant to dissolution in the physiological environment.…”

Section: Starchmentioning

confidence: 99%

Designing polymeric microparticles for biomedical and industrial applications

Campos

Branquinho

Carreira

et al. 2013

European Polymer Journal

161

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“…INTRODUCTION: Native starches are less favored in direct compression of tablet dosage form and are inappropriate for controlling drug release. Hence, they are chemically modified to improve their direct compression and drug release sustaining properties [1][2][3][4][5][6][7] . Most studies on the production of chemically modified starches have been limited to widely available starches such as maize, potato, wheat, tapioca and rice.…”

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confidence: 99%

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2013

IJPSR

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Enset (Ensete ventricosum, Musaceae), a plant widely cultivated in south and southwest of Ethiopia, has been shown to be a rich source of starch. In an effort to produce directly compressible matrixforming excipient, native enset starch was acetylated. Starch acetates (SA) with degrees of substitution (DS) of 0.672 and 2.142 were evaluated. Fourier transform infrared (FTIR) spectra of the modified starches verified the acetylation of the starch molecules. Further investigations revealed that acetylation increased swelling power and solubility, improved flow property and compactability of the starch. The tensile strength of SA matrix tablets increased with an increase in DS. Plain tablets of SA with DS 0.672 disintegrated within 3 min while those of SA with DS 2.142 did not disintegrate over a period of 2 h. Dissolution studies of theophylline loaded SA tablets conducted in 0.1 N HCl for the first 1.5 h and in phosphate buffer pH 6.8 for the remaining study time revealed the change in drug release rate from rapid to sustained release (>12 h) as the DS increased from 0.672 to 2.142. The dissolution data obtained best fitted Higuchi model with R 2 > 0.99. The drug release diffusional exponent (n), obtained from Korsemeyer-Peppas model, varied between 0.4899 -0.6369 for different theophylline/SA ratios and the goodness of the fit was > 0.99 in each case which indicated the deviation from Fickian diffusion. Accordingly, high degree of acetylation renders enset starch highly compressible and suitable for sustained release formulations that makes it amenable for use as an alternative pharmaceutical excipient. INTRODUCTION: Native starches are less favored in direct compression of tablet dosage form and are inappropriate for controlling drug release. Hence, they are chemically modified to improve their direct compression and drug release sustaining properties [1][2][3][4][5][6][7] . Most studies on the production of chemically modified starches have been limited to widely available starches such as maize, potato, wheat, tapioca and rice.Enset (Ensete ventricosum, Musaceae), a plant cultivated in many parts of Ethiopia and used as staple food in south and southwest of the country, has been shown to be a rich source of starch with amylose content of 29% 8 .The potential applications of native enset starch have been extended by chemical modification technique 9, 10 .

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Preparation of crosslinked starch microspheres and their drug loading and releasing properties

Cited by 95 publications

References 19 publications

Morphology and thermal stability of silk fibroin/starch blended microparticles

Morphology and thermal stability of silk fibroin/starch blended microparticles

Designing polymeric microparticles for biomedical and industrial applications

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