Preparation of curcumin-poly (allyl amine) hydrochloride based nanocapsules: Piperine in nanocapsules accelerates encapsulation and release of curcumin and effectiveness against colon cancer cells

Slika, Layal; Moubarak, Alaa Al; Borjac, Jamilah; Baydoun, Elias; Patra, Digambara

doi:10.1016/j.msec.2019.110550

Cited by 50 publications

(25 citation statements)

References 46 publications

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“…However, crystalline peaks disappeared in the XRD pattern of PPNPS at the ratio of 1:6, 1:8 and 1:10. In fact, this crystallinity modification could be attributed to PVP, which may have surrounded the crystal aggregates of phlorotannin during the preparation of PPNPS, thus forming an amorphous shell [ 25 ]. These results are consistent with previous reports which showed that the physical state of lutein was converted from crystalline to amorphous due to encapsulation and the chemical interactions between lutein and PVP during nanoparticle preparation [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

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Preparation, Characterization and Antioxidant Activities of Kelp Phlorotannin Nanoparticles

Bai

Sun

et al. 2020

Molecules

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Phlorotannins are a group of major polyphenol secondary metabolites found only in brown algae and are known for their bioactivities and multiple health benefits. However, they can be oxidized due to external factors and their bioavailability is low due to their low water solubility. In this study, the potential of utilizing nanoencapsulation with polyvinylpyrrolidone (PVP) to improve various activities of phlorotannins was explored. Phlorotannins encapsulated by PVP nanoparticles (PPNPS) with different loading ratios were prepared for characterization. Then, the PPNPS were evaluated for in vitro controlled release of phlorotannin, toxicity and antioxidant activities at the ratio of phlorotannin to PVP 1:8. The results indicated that the PPNPS showed a slow and sustained kinetic release of phlorotannin in simulated gastrointestinal fluids, they were non-toxic to HaCaT keratinocytes and they could reduce the generation of endogenous reactive oxygen species (ROS). Therefore, PPNPS have the potential to be a useful platform for the utilization of phlorotannin in both pharmaceutical and cosmetics industries.

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Section: Resultsmentioning

confidence: 99%

“…An in vitro release profile is usually used to predict in vivo behavior, drug dosage, release mechanism and kinetics of encapsulated drugs [ 25 ]. As shown in Figure 4 , the release characteristics of free phlorotannin and phlorotannin from the PPNPS under simulated gastrointestinal conditions were studied.…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Antioxidant Activities of Kelp Phlorotannin Nanoparticles

Bai

Sun

et al. 2020

Molecules

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“…In vivo and in vitro cytotoxicity studies exhibited that drug-loaded polymeric nanocapsules exerted potential and selective cytotoxic activity against Caco-2-cancer cell lines. Furthermore, curcumin-loaded nanocarriers improved the cytotoxic efficacy of curcumin by 3-fold [118].…”

Section: Nanocapsulesmentioning

confidence: 96%

“…Slika et al formulated polymer-based nanocapsules via the self-assembled nanoprecipitation method encapsulated with curcumin and piperine, using poly (allyl amine) hydrochloride as the carrier [118]. The physiochemical properties of the polymeric nanocapsules were evaluated using FTIR, XRD, SEM, DLS, and zeta potential analysis.…”

Section: Nanocapsulesmentioning

confidence: 99%

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Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

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Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers to result in promising therapeutic outcomes in cancer treatment. Curcumin exhibits good anticancer activity but its poor bioavailability has resulted in its incorporation into several polymer-based nanocarriers resulting in good biological outcomes. Furthermore, the incorporation of curcumin together with other anticancer drugs have been reported to result in excellent therapeutic outcomes in vivo and in vitro. Due to the potential of polymer-based nanocarriers, this review article will be focused on the design of polymer-based nanocarriers loaded with curcumin together with other anticancer drugs.

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Comprehensive Insights Into the Combinatorial Uses of Selected Phytochemicals in Colorectal Cancer Prevention and Treatment: Isothiocyanates, Quinones, Carotenoids, and Alkaloids

Deng,

Yang,

Han

et al. 2024

Phytotherapy Research

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Despite the advancement in cancer diagnosis and treatment, colorectal cancer remains the leading cause of cancer‐related death worldwide. Given the high recurrence rate of colorectal cancer even after surgical resection, chemotherapy has been clinically used to improve the treatment outcomes of colorectal cancer. However, chemotherapy is well‐known for its toxic side effects. Thus, phytochemicals have been widely studied in recent years as preventive and therapeutic agents for colorectal cancer owing to their relatively low toxicity. Moreover, combinatorial uses of phytochemicals with other natural compounds or with drugs may amplify the positive outcomes of colorectal cancer prevention and treatment by intervening in multiple signaling pathways and targets. This review summarized the combinatorial use of several well‐studied groups of phytochemicals, that is, isothiocyanates, quinones, carotenoids, and alkaloids, in the prevention and treatment of colorectal cancer, and suggested it as a potential approach to improve the anticancer efficacy of single compounds and minimize the toxic side effects associated with conventional drugs. Notably, we generalized the in vitro, in vivo, and clinical experiments‐based molecular mechanisms whereby the selected phytochemicals in combination with other compounds exerted anti‐colorectal cancer effects by inhibiting cancer cell proliferation, cell apoptosis, cell invasion, and tumor growth. Overall, this review provides a reference and new perspective to propel further advancements in research and development of preventative and therapeutic strategies for colorectal cancer.

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Preparation of curcumin-poly (allyl amine) hydrochloride based nanocapsules: Piperine in nanocapsules accelerates encapsulation and release of curcumin and effectiveness against colon cancer cells

Cited by 50 publications

References 46 publications

Preparation, Characterization and Antioxidant Activities of Kelp Phlorotannin Nanoparticles

Preparation, Characterization and Antioxidant Activities of Kelp Phlorotannin Nanoparticles

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Comprehensive Insights Into the Combinatorial Uses of Selected Phytochemicals in Colorectal Cancer Prevention and Treatment: Isothiocyanates, Quinones, Carotenoids, and Alkaloids

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