Preparation of d-mannose from doum-palm kernels

Sallam, Mohammed A.E.

doi:10.1016/s0008-6215(00)85463-4

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…All parts of the tree (leaves, seeds, fruit, wood and roots) are applied for the manufacture of several traditional products 3,5 and are applied in folk medicine for the treatment of various disorders 3,6 . Phytochemical investigation of different parts of doum-palm indicated its high content of phenolics: flavonoids and phenolic acids (fruits [7][8][9][10][11] and leaves 12 ), volatile oil 13 , fatty acids 11 , polysaccharides in particular mannan (seeds) 14,15 and estrone (seeds) 16 .…”

Section: Introductionmentioning

confidence: 99%

The INHIBITORY EFFECT OF DOUM PALM (HYPHAENE THEBAICA L. MART.) LEAVES EXTRACT ON Α-Glucosidase ACTIVITY

Khallaf

Wahman

Farghaly

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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Background: Hyphaene thebaica L. Mart. (Doum-palm), rich in total phenolics content, is known for its medicinal value in the treatment of several health conditions, such as hypertension, and diabetes mellitus. Aim of the Study: To investigate the hypoglycaemic activity of the dichloromethane, ethyl acetate, and aqueous fractions from doum palm leaves. Then, to characterize the metabolic profile of the most active fraction by LC-HR-MS/MS analysis to detect the responsible metabolites for this activity. Material and Methods: The present study examined the in vitro inhibitory effect of the extract fractions from Doum Palm Leaves at concentrations ranging from 7.81 to 1000.00 μg/ml on α-glucosidase activity, an enzyme responsible for carbohydrate-hydrolysis to monosaccharides and intestinal glucose absorption. Metabolic profiling for the dichloromethane fraction was obtained with LC-HR-MS/MS. Results: The dichloromethane (DCM) fraction inhibited α-glucosidase activity in vitro with an IC 50 of 52.40 μg/ml. Twenty-three compounds were identified in the DCM fraction by LC-HR-MS/MS analysis. Most of them were reported for their potential antidiabetic activity. Nevertheless, the III-DCM subfraction (IC 50 3.79 ± 0.17 μg/ml) and the IV-DCM subfraction (IC 50 5.13 ± 0.24 μg/ml) had the best inhibitory activity against α-glucosidase compared with acarbose (IC 50 2.33 ± 0.11 μg/ml). Conclusions: The results support the use of these fractions obtained from Doum palm leaves to effectively inhibit a crucial enzyme linked to type 2 diabetes and suppress carbohydrate absorption from intestine, and thereby reducing the postprandial increase of blood glucose.

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Section: Introductionmentioning

confidence: 99%