Preparation of Doxorubicin- and Psoralen-Loaded Nanostructured Lipid Carrier and Its Multidrug Resistance Reversal Study

Cai, Tiange; Huang, Yinghong; Du, Chuling; Xia, Xi; Yang, Li; Han, Li; Cai, Yu

doi:10.1166/jbt.2016.1513

Cited by 1 publication

(2 citation statements)

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“…However, siRNAs loaded in nanoparticles significantly decrease the clearance rate such that 30% of the siRNA remains in the blood after 30 min. 67 The remaining 20% of the siRNA content in the blood was also reported 24 hr following the administration using a ligand-functionalized liposomal formulation. 68 A variety of nanocarrier platforms, including liposomes, dendrimers, micelles, and silica nanoparticles, are among other nanoparticle formulations used to deliver combinations of siRNA and chemotherapy drugs.…”

Section: Rna Interference Therapymentioning

confidence: 99%

“…It was reported that the clearance rate of unmodified siRNA from the blood was within minutes and mediated by degradation and renal excretion. However, siRNAs loaded in nanoparticles significantly decrease the clearance rate such that 30% of the siRNA remains in the blood after 30 min . The remaining 20% of the siRNA content in the blood was also reported 24 hr following the administration using a ligand‐functionalized liposomal formulation .…”

Section: Novel Strategies Against Mdrmentioning

confidence: 99%

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Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Majidinia

Mirza-Aghazadeh-Attari

Rahimi

et al. 2020

IUBMB Life

124

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Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both conventional and novel chemotherapy agents, is an important barrier in treating malignancies. Initially, it was discovered that cellular pumps dependent on ATP were the cause of resistance to chemotherapy, and further studies have found that other mechanisms such as increased metabolism of drugs, decreased drug entry, and defective apoptotic pathways are involved in this process. MDR has been the focus of numerous initiatives and countless studies have been undertaken to better understand MDR and formulate strategies to overcome its effects. The current review highlights various nano‐drug delivery systems including polymeric/solid lipid/mesoporous silica/metal nanoparticles, dendrimers, liposomes, micelles, and nanostructured lipid carriers to overcome the mechanism of MDR. Nanoparticles are novel gateways to enhance the therapeutic efficacy of anticancer agents at the target site of action due to their tumor‐targeting abilities, which can limit the unwanted systemic effects of chemotherapy agents and also reduce drug resistance. Additionally, other innovative strategies including RNA interference as a biological process used to inhibit or silence specific gene expression, natural products as MDR modulators with little systemic toxic effects, which interfere with the functions of proteins involved in drug efflux, and physical approaches such as combination of conventional drug administration with thermal/ultrasound/photodynamic strategies are also highlighted.

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Section: Rna Interference Therapymentioning

confidence: 99%

Section: Novel Strategies Against Mdrmentioning

confidence: 99%