Preparation of doxorubicin loaded Poly(ethylene glycol)-Poly(ε-caprolactone)-hydroxyapatite fibres as drug delivery systems

Guo, QingFa; Fan-yuan, Kong; Ma, Chao

doi:10.1080/10667857.2019.1674477

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…It is known for its compatibility with other polymers and excellent processability, which makes it an appropriate choice for applications in cell culture and drug delivery. 2,13,94,95 Overall, the utilization of natural and synthetic biomaterials in the construction of 3D platforms for BC culture shows significant potential for enhancing our comprehension of the disease and creating more efficient therapeutic approaches 6 (Figure 3).…”

Section: Methodsmentioning

confidence: 99%

“…PCL, a type of synthetic polymer that is classified as an aliphatic polyester, 92 is commonly utilized for scaffold fabrication because of its low cost and rheological and viscoelastic properties, 93 as well as its lack of isomers. It is known for its compatibility with other polymers and excellent processability, which makes it an appropriate choice for applications in cell culture and drug delivery 2,13,94,95 . Overall, the utilization of natural and synthetic biomaterials in the construction of 3D platforms for BC culture shows significant potential for enhancing our comprehension of the disease and creating more efficient therapeutic approaches 6 (Figure 3).…”

Section: Methodsmentioning

confidence: 99%

“…Laiva et al created hybrid nanofiber scaffolds for sustained release of titanocene, which effectively suppressed MCF‐7 BC cell growth over 5 days, demonstrating potential for localized delivery 93 . Polyethylene Glycol (PEG)‐PCL‐hydroxyapatite (HA) composite nanofibers carrying DOX were synthesized by Guo et al These nanofibers showed cytotoxicity and sustained release against cancer cells 95 . Rezaie et al used stem cell exosomes in PCL nanofibers for extended release, resulting in enhanced anticancer effects against BC cells compared to standard treatments 98 .…”

Section: Application Of 3d Breast Cancer Modelsmentioning

confidence: 99%

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Recent advances in scaffold based electrospun for breast cancer research

Ebrahimbaygi,

Khazaei,

Valadbeigi

et al. 2024

Polymers for Advanced Techs

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One of the biggest challenges facing public health in the modern era is the management of cancer, a global health issue. Breast cancer (BC) is the most common malignancy among women worldwide. Among the most popular cancer treatment modalities are radiation, chemotherapy, and surgery. Chemotherapy, however, is regarded as the primary treatment option for cancer that has progressed to the final and metastatic stages. However, because of things like toxicity to healthy cells, poor drug absorption, trouble getting drugs to target tumor sites, and low therapeutic efficacy, traditional chemotherapy approaches are frequently insufficient. Nanotechnology offers the potential to overcome some of these limitations by creating new materials with unique properties through electrospinning. A straightforward and reasonably priced technique for creating biomaterials that can replicate the topography and structure of the cellular matrix is electrospinning. These materials have a large surface area, can be mechanically controlled, and have a level of fibers that can be adjusted from micrometers to nanometers. This review article emphasizes the potential of electrospun scaffolds for the treatment of BC while also offering a basic understanding of the procedure and nanostructured fibrous materials. This article reviews the most recent emerging electrospinning techniques in BC therapy. First, it briefly introduces the progress made in electrospinning in BC research over the past few years. Next, it investigates electrospinning by summarizing the techniques and materials used in the process. In addition, it demonstrates how crucial electrospinning three‐dimensional (3D) models are for the diagnosis and treatment of BC. This article also clarifies numerous electrospinning uses in several fields, such as cell culture, drug delivery, drug loading, and gene therapy. The final section discusses the advantages, limitations, and challenges electrospinning is willing to encounter in BC research.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Application Of 3d Breast Cancer Modelsmentioning

confidence: 99%

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Recent advances in scaffold based electrospun for breast cancer research

Ebrahimbaygi,

Khazaei,

Valadbeigi

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…There seems to be a large focus on specific areas where delivery for timely and targeted action is crucial such as anticancer delivery. Chemotherapeutics such as 5FU [352][353][354][355][356][357][358], doxorubicin [356,[359][360][361][362], paclitaxel [363][364][365][366], cisplatin [367][368][369] and metformin [370] have been used as model drugs to show the effectiveness of ES in cancer therapy. For example, Ghahreman et al fabricated 5FU-loaded PCL/gelatin fibers which showed by increasing the amount of gelatin in the composition; drug release increased [354].…”

Section: Electrospinningmentioning

confidence: 99%